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OPENSEQ.org
YEAW - Putative dioxygenase subunit alpha YeaW
UniProt: P0ABR7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13509
Length: 374 (355)
Sequences: 1846
Seq/Len: 5.20
YEAW
Paralog alert: 0.60 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: HCAE YEAW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
90_P 116_F 5.511 1.00
61_D 102_K 4.397 1.00
53_S 148_E 4.146 1.00
32_Q 36_E 3.896 1.00
196_P 292_T 3.764 1.00
77_G 83_R 3.586 1.00
289_D 292_T 3.326 1.00
58_N 61_D 3.284 1.00
147_E 165_E 3.266 1.00
117_K 121_N 3.167 1.00
83_R 143_P 2.896 1.00
84_A 146_L 2.89 1.00
84_A 155_I 2.869 1.00
35_F 289_D 2.866 1.00
77_G 81_V 2.819 1.00
36_E 39_K 2.771 1.00
135_D 138_K 2.506 1.00
194_R 292_T 2.493 1.00
163_S 166_D 2.488 1.00
147_E 164_V 2.486 1.00
58_N 102_K 2.448 1.00
51_A 153_V 2.441 1.00
291_E 337_K 2.308 1.00
196_P 330_E 2.295 1.00
74_L 84_A 2.289 1.00
209_C 212_C 2.183 1.00
288_V 292_T 2.165 1.00
75_V 107_I 2.159 1.00
45_K 158_D 2.141 1.00
50_V 155_I 2.136 1.00
146_L 153_V 2.081 1.00
51_A 63_V 2.024 1.00
72_I 84_A 2.022 1.00
156_N 161_A 1.997 1.00
27_R 31_D 1.985 1.00
64_T 71_S 1.967 1.00
158_D 161_A 1.966 1.00
117_K 123_A 1.855 1.00
125_A 134_F 1.85 1.00
37_H 41_N 1.849 1.00
111_Y 205_N 1.823 1.00
72_I 155_I 1.792 1.00
215_A 328_L 1.777 1.00
165_E 172_G 1.77 1.00
59_A 80_K 1.751 1.00
181_E 184_D 1.741 1.00
32_Q 290_S 1.7 1.00
62_Y 101_G 1.698 1.00
95_Q 334_K 1.675 0.99
55_E 63_V 1.675 0.99
194_R 294_L 1.673 0.99
145_R 156_N 1.636 0.99
56_L 76_R 1.635 0.99
73_V 85_F 1.627 0.99
70_E 339_R 1.623 0.99
35_F 39_K 1.616 0.99
39_K 44_A 1.592 0.99
35_F 288_V 1.591 0.99
96_L 107_I 1.588 0.99
218_G 324_E 1.584 0.99
288_V 294_L 1.565 0.99
148_E 153_V 1.552 0.99
82_L 146_L 1.544 0.99
39_K 68_I 1.527 0.99
82_L 153_V 1.52 0.99
75_V 83_R 1.52 0.99
75_V 118_L 1.492 0.99
184_D 303_N 1.492 0.99
162_T 166_D 1.489 0.99
94_H 110_P 1.487 0.99
52_H 152_F 1.463 0.98
39_K 69_G 1.457 0.98
33_N 37_H 1.424 0.98
24_I 28_F 1.412 0.98
85_F 143_P 1.394 0.97
60_N 118_L 1.386 0.97
113_A 214_P 1.381 0.97
70_E 86_Y 1.38 0.97
56_L 61_D 1.378 0.97
57_A 61_D 1.372 0.97
90_P 139_A 1.37 0.97
154_F 269_T 1.353 0.97
33_N 36_E 1.335 0.97
145_R 161_A 1.327 0.96
79_D 83_R 1.318 0.96
97_L 107_I 1.312 0.96
82_L 148_E 1.307 0.96
47_W 205_N 1.305 0.96
81_V 143_P 1.301 0.96
211_H 216_H 1.288 0.95
72_I 157_M 1.28 0.95
74_L 153_V 1.269 0.95
201_N 332_V 1.246 0.94
288_V 293_T 1.24 0.94
145_R 160_N 1.237 0.94
34_A 37_H 1.228 0.94
285_E 293_T 1.208 0.93
35_F 293_T 1.204 0.93
145_R 158_D 1.183 0.92
36_E 69_G 1.176 0.92
32_Q 291_E 1.173 0.92
87_N 198_N 1.17 0.91
76_R 82_L 1.166 0.91
197_A 202_I 1.162 0.91
164_V 168_L 1.157 0.91
368_L 372_F 1.147 0.90
87_N 97_L 1.138 0.90
44_A 70_E 1.137 0.90
291_E 333_Q 1.136 0.90
91_H 112_H 1.131 0.90
53_S 76_R 1.126 0.89
33_N 59_A 1.123 0.89
147_E 168_L 1.121 0.89
121_N 137_D 1.12 0.89
366_N 369_A 1.118 0.89
205_N 208_E 1.117 0.89
90_P 140_Q 1.11 0.88
51_A 74_L 1.101 0.88
90_P 142_V 1.1 0.88
197_A 201_N 1.091 0.87
40_E 44_A 1.089 0.87
62_Y 97_L 1.083 0.87
119_D 123_A 1.079 0.86
53_S 151_G 1.076 0.86
86_Y 144_V 1.066 0.85
192_T 294_L 1.066 0.85
115_A 123_A 1.064 0.85
333_Q 337_K 1.06 0.85
94_H 332_V 1.057 0.85
206_Y 329_V 1.051 0.84
66_E 69_G 1.043 0.84
211_H 325_D 1.042 0.84
192_T 296_N 1.041 0.84
42_V 368_L 1.04 0.84
29_Y 333_Q 1.037 0.83
132_A 135_D 1.036 0.83
187_L 300_Y 1.032 0.83
48_I 157_M 1.022 0.82
28_F 32_Q 1.011 0.81
52_H 149_Y 1.006 0.81
66_E 71_S 1.006 0.81
62_Y 107_I 1.003 0.80
56_L 82_L 1.002 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3vcaA10.95451000.268Contact Map0.767
3n0qA10.94651000.272Contact Map0.795
3gzxA10.9841000.334Contact Map0.761
2bmoA10.95991000.344Contact Map0.689
1uliA30.98131000.344Contact Map0.777
2gbwA30.95991000.346Contact Map0.728
2b1xA30.9841000.346Contact Map0.776
1z01A60.93851000.405Contact Map0.624
3gkeA30.84491000.441Contact Map0.734
2zylA10.85291000.453Contact Map0.613
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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