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OPENSEQ.org
HCAE - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
UniProt: P0ABR5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13456
Length: 453 (427)
Sequences: 724
Seq/Len: 1.70
HCAE
Paralog alert: 0.32 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: HCAE YEAW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
57_D 99_N 5.23 1.00
86_R 112_Y 4.095 1.00
80_A 154_G 3.85 1.00
164_R 171_A 3.654 1.00
46_L 154_G 3.483 1.00
31_Y 329_G 3.233 1.00
146_E 164_R 3.115 1.00
49_E 147_S 3.007 1.00
113_G 117_E 3.001 1.00
197_N 332_Q 2.885 1.00
47_A 70_V 2.875 1.00
54_K 57_D 2.803 1.00
73_Q 79_K 2.774 1.00
68_V 154_G 2.693 1.00
54_K 99_N 2.579 1.00
121_V 132_L 2.551 1.00
162_G 165_D 2.55 1.00
32_Q 35_L 2.493 1.00
161_P 165_D 2.429 1.00
73_Q 77_S 2.429 1.00
28_P 32_Q 2.397 1.00
44_L 63_M 2.396 1.00
148_Y 175_D 2.188 0.99
329_G 332_Q 2.092 0.99
64_G 68_V 2.085 0.99
195_V 332_Q 2.056 0.99
80_A 142_V 2.053 0.99
31_Y 328_R 2.048 0.99
155_N 160_A 2.022 0.99
157_D 160_A 1.99 0.98
52_I 57_D 1.974 0.98
124_E 134_K 1.938 0.98
70_V 152_I 1.93 0.98
146_E 163_L 1.92 0.98
46_L 80_A 1.917 0.98
55_P 76_G 1.909 0.98
23_R 27_D 1.874 0.97
52_I 70_V 1.847 0.97
79_K 141_E 1.846 0.97
133_C 136_H 1.825 0.97
47_A 152_I 1.737 0.95
41_R 157_D 1.729 0.95
69_V 81_F 1.726 0.95
49_E 150_G 1.714 0.95
33_L 432_L 1.695 0.95
144_C 158_T 1.677 0.94
80_A 145_V 1.663 0.94
51_Q 59_F 1.652 0.94
197_N 376_C 1.647 0.94
71_V 79_K 1.61 0.92
190_G 354_E 1.566 0.91
328_R 332_Q 1.552 0.91
289_A 293_Q 1.55 0.91
33_L 37_R 1.528 0.90
33_L 36_E 1.512 0.89
56_G 114_I 1.498 0.88
52_I 72_R 1.487 0.88
427_R 430_D 1.486 0.88
75_D 79_K 1.479 0.88
147_S 163_L 1.479 0.88
58_F 95_A 1.455 0.86
145_V 152_I 1.454 0.86
30_I 300_A 1.447 0.86
428_W 432_L 1.445 0.86
149_K 179_D 1.435 0.85
144_C 160_A 1.427 0.85
36_E 40_G 1.415 0.84
142_V 154_G 1.397 0.83
18_G 396_M 1.372 0.82
167_L 309_I 1.37 0.82
60_N 67_A 1.357 0.81
29_D 33_L 1.349 0.80
63_M 142_V 1.329 0.79
55_P 78_I 1.327 0.79
403_R 408_I 1.323 0.78
153_F 167_L 1.322 0.78
75_D 81_F 1.318 0.78
31_Y 65_E 1.308 0.77
427_R 431_L 1.306 0.77
71_V 103_F 1.3 0.77
158_T 196_I 1.298 0.76
175_D 370_D 1.293 0.76
53_P 71_V 1.288 0.76
403_R 406_D 1.288 0.76
28_P 331_D 1.286 0.75
49_E 78_I 1.284 0.75
35_L 65_E 1.263 0.74
426_Q 429_A 1.257 0.73
429_A 433_S 1.255 0.73
401_E 407_G 1.245 0.72
141_E 158_T 1.231 0.71
21_T 391_K 1.228 0.71
35_L 64_G 1.226 0.70
144_C 155_N 1.224 0.70
28_P 330_P 1.219 0.70
79_K 115_N 1.217 0.70
426_Q 430_D 1.213 0.69
65_E 329_G 1.206 0.69
68_V 80_A 1.203 0.68
78_I 152_I 1.2 0.68
30_I 141_E 1.179 0.66
328_R 334_E 1.178 0.66
196_I 375_W 1.173 0.66
147_S 152_I 1.172 0.65
130_Q 430_D 1.169 0.65
63_M 156_W 1.162 0.64
32_Q 164_R 1.162 0.64
207_F 325_W 1.157 0.64
69_V 321_T 1.157 0.64
396_M 410_G 1.155 0.64
19_R 395_E 1.151 0.63
157_D 162_G 1.142 0.62
397_G 406_D 1.137 0.62
316_L 360_A 1.133 0.62
76_G 258_D 1.124 0.61
360_A 367_L 1.123 0.61
55_P 115_N 1.119 0.60
394_L 397_G 1.118 0.60
174_L 315_W 1.118 0.60
10_Y 13_I 1.116 0.60
64_G 154_G 1.114 0.60
90_M 378_I 1.107 0.59
73_Q 136_H 1.096 0.58
29_D 293_Q 1.091 0.57
31_Y 330_P 1.084 0.56
70_V 80_A 1.081 0.56
78_I 386_R 1.081 0.56
296_G 300_A 1.078 0.56
194_W 375_W 1.076 0.56
331_D 383_K 1.07 0.55
92_V 112_Y 1.066 0.55
160_A 174_L 1.064 0.54
155_N 398_L 1.063 0.54
402_K 405_D 1.061 0.54
31_Y 333_V 1.061 0.54
69_V 312_T 1.058 0.54
355_N 358_T 1.058 0.54
63_M 347_D 1.056 0.54
88_R 212_Y 1.056 0.54
46_L 73_Q 1.056 0.54
20_V 433_S 1.05 0.53
117_E 164_R 1.05 0.53
61_T 425_Y 1.05 0.53
118_L 373_E 1.049 0.53
144_C 159_S 1.046 0.52
353_F 360_A 1.046 0.52
148_Y 210_D 1.044 0.52
107_Y 206_Q 1.038 0.52
153_F 163_L 1.037 0.52
397_G 403_R 1.034 0.51
198_C 333_V 1.027 0.50
112_Y 361_F 1.026 0.50
270_P 288_Y 1.021 0.50
425_Y 428_W 1.021 0.50
63_M 69_V 1.02 0.50
30_I 434_S 1.017 0.49
25_Y 84_Q 1.016 0.49
210_D 365_G 1.015 0.49
143_P 225_L 1.014 0.49
198_C 375_W 1.014 0.49
93_S 373_E 1.012 0.49
310_F 431_L 1.011 0.49
283_Y 410_G 1.01 0.49
333_V 358_T 1.01 0.49
113_G 119_I 1.009 0.49
397_G 400_Q 1.009 0.49
77_S 141_E 1.007 0.48
117_E 138_G 1.005 0.48
22_P 25_Y 1.005 0.48
35_L 38_I 1.004 0.48
33_L 193_K 1.004 0.48
200_W 371_D 1.003 0.48
46_L 70_V 1 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gzxA10.9471000.28Contact Map0.662
2bmoA10.95581000.288Contact Map0.575
2gbwA30.95811000.288Contact Map0.634
1uliA30.97351000.289Contact Map0.657
2b1xA30.94921000.323Contact Map0.654
3vcaA10.88521000.47Contact Map0.619
3n0qA10.88081000.475Contact Map0.645
1z01A60.86751000.585Contact Map0.472
3gcfA150.82561000.672Contact Map0.568
2de6A30.81241000.673Contact Map0.523
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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