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OPENSEQ.org
ILVE - Branched-chain-amino-acid aminotransferase
UniProt: P0AB80 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10497
Length: 309 (302)
Sequences: 3948
Seq/Len: 13.07
ILVE
Paralog alert: 0.63 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ILVE PABC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
141_D 267_S 4.284 1.00
208_L 230_A 3.775 1.00
240_Q 246_S 3.693 1.00
207_V 238_R 3.317 1.00
59_Q 76_I 3.216 1.00
207_V 236_E 2.958 1.00
15_M 89_K 2.746 1.00
62_H 76_I 2.639 1.00
81_E 85_D 2.597 1.00
85_D 89_K 2.574 1.00
291_G 296_E 2.556 1.00
209_F 240_Q 2.517 1.00
35_S 162_G 2.43 1.00
85_D 88_R 2.372 1.00
75_S 78_E 2.343 1.00
219_P 224_D 2.283 1.00
253_V 265_V 2.241 1.00
227_I 237_V 2.233 1.00
61_L 101_I 2.164 1.00
43_Y 261_E 2.09 1.00
287_Q 291_G 2.079 1.00
191_Y 241_V 2.039 1.00
12_N 119_D 2.037 1.00
233_L 284_R 2.003 1.00
69_R 177_R 1.962 1.00
142_A 195_G 1.955 1.00
233_L 288_A 1.919 1.00
195_G 198_E 1.912 1.00
84_R 305_D 1.91 1.00
56_E 224_D 1.888 1.00
224_D 228_K 1.873 1.00
36_V 64_S 1.868 1.00
66_K 72_V 1.841 1.00
199_N 220_G 1.818 1.00
203_V 281_V 1.797 1.00
82_A 120_V 1.785 1.00
143_M 178_H 1.749 1.00
65_A 101_I 1.746 1.00
283_K 287_Q 1.732 1.00
143_M 180_Y 1.718 1.00
70_F 101_I 1.716 1.00
55_R 80_M 1.706 1.00
200_L 253_V 1.698 1.00
291_G 297_T 1.696 1.00
204_K 251_D 1.665 1.00
36_V 65_A 1.659 1.00
34_T 103_V 1.655 1.00
142_A 265_V 1.652 1.00
36_V 61_L 1.648 1.00
226_I 256_S 1.648 1.00
140_I 181_Q 1.643 1.00
208_L 235_I 1.628 1.00
54_H 58_M 1.6 1.00
146_S 174_E 1.581 1.00
17_R 20_D 1.58 1.00
29_A 35_S 1.56 1.00
174_E 178_H 1.557 1.00
228_K 232_E 1.553 1.00
18_W 24_H 1.549 1.00
59_Q 63_D 1.531 1.00
46_H 296_E 1.515 1.00
45_S 50_V 1.513 1.00
223_R 239_E 1.471 1.00
253_V 268_V 1.454 1.00
63_D 66_K 1.449 1.00
288_A 297_T 1.438 1.00
242_L 246_S 1.436 1.00
81_E 84_R 1.429 1.00
201_F 254_F 1.426 1.00
8_Y 89_K 1.417 1.00
195_G 255_M 1.407 0.99
232_E 301_W 1.393 0.99
284_R 288_A 1.386 0.99
144_V 244_R 1.382 0.99
144_V 269_D 1.375 0.99
210_T 223_R 1.373 0.99
267_S 270_G 1.362 0.99
54_H 80_M 1.34 0.99
15_M 86_V 1.334 0.99
252_E 279_G 1.334 0.99
53_R 225_A 1.334 0.99
10_W 74_Q 1.333 0.99
202_E 242_L 1.328 0.99
55_R 59_Q 1.318 0.99
63_D 219_P 1.286 0.99
142_A 184_I 1.282 0.99
141_D 181_Q 1.282 0.99
191_Y 243_S 1.276 0.99
42_C 87_I 1.27 0.99
80_M 84_R 1.267 0.99
86_V 90_N 1.258 0.99
134_E 138_Q 1.247 0.99
201_F 256_S 1.246 0.98
231_K 239_E 1.241 0.98
184_I 200_L 1.234 0.98
51_V 83_C 1.229 0.98
279_G 282_T 1.221 0.98
202_E 250_A 1.22 0.98
231_K 236_E 1.22 0.98
10_W 82_A 1.219 0.98
252_E 282_T 1.212 0.98
284_R 287_Q 1.211 0.98
288_A 291_G 1.203 0.98
56_E 59_Q 1.198 0.98
40_I 51_V 1.198 0.98
232_E 300_K 1.192 0.98
187_D 216_S 1.175 0.98
77_D 81_E 1.171 0.98
141_D 266_R 1.17 0.97
202_E 253_V 1.167 0.97
202_E 209_F 1.165 0.97
8_Y 17_R 1.156 0.97
37_F 165_Y 1.155 0.97
62_H 72_V 1.152 0.97
101_I 120_V 1.152 0.97
209_F 238_R 1.151 0.97
230_A 235_I 1.146 0.97
82_A 122_I 1.144 0.97
58_M 80_M 1.143 0.97
182_E 196_A 1.138 0.97
51_V 54_H 1.135 0.97
83_C 122_I 1.125 0.97
257_G 260_A 1.123 0.97
201_F 227_I 1.112 0.96
83_C 97_I 1.101 0.96
58_M 83_C 1.096 0.96
278_C 283_K 1.092 0.96
255_M 265_V 1.086 0.96
201_F 210_T 1.085 0.96
267_S 272_Q 1.085 0.96
173_S 177_R 1.085 0.96
86_V 124_A 1.082 0.96
64_S 159_A 1.065 0.95
248_Y 271_I 1.064 0.95
142_A 255_M 1.064 0.95
92_L 95_A 1.061 0.95
184_I 247_L 1.059 0.95
182_E 195_G 1.048 0.94
56_E 228_K 1.036 0.94
58_M 79_L 1.032 0.94
30_L 102_F 1.028 0.94
230_A 285_I 1.023 0.93
31_H 98_R 1.022 0.93
204_K 249_L 1.021 0.93
213_F 223_R 1.02 0.93
201_F 223_R 1.016 0.93
87_I 95_A 1.016 0.93
100_L 121_I 1.014 0.93
203_V 208_L 1.011 0.93
39_G 257_G 1.011 0.93
223_R 227_I 1.008 0.93
53_R 56_E 1.007 0.93
29_A 102_F 1.007 0.93
44_D 93_T 1.004 0.93
187_D 191_Y 1.003 0.93
212_P 241_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1iyeA311000.093Contact Map0.838
2eiyA30.99031000.115Contact Map0.807
3u0gA60.98711000.118Contact Map0.855
4m0jA20.94821000.164Contact Map0.721
3daaA20.89321000.175Contact Map0.795
4dqnA10.97411000.179Contact Map0.697
4jxuA20.92881000.19Contact Map0.766
3dthA20.97731000.191Contact Map0.739
3uzoA20.96761000.201Contact Map0.711
2xpfA10.89641000.205Contact Map0.723
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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