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OPENSEQ.org
YBDG - Miniconductance mechanosensitive channel YbdG
UniProt: P0AAT4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12620
Length: 415 (394)
Sequences: 860
Seq/Len: 2.18
YBDG
Paralog alert: 0.22 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: MSCS YBDG YNAI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_S 60_L 3.983 1.00
112_L 152_V 3.469 1.00
274_I 324_I 2.702 1.00
220_I 230_R 2.637 1.00
55_S 61_Q 2.509 1.00
278_D 281_E 2.332 1.00
364_Y 372_W 2.282 1.00
369_T 374_E 2.165 1.00
207_W 232_W 2.06 0.99
331_L 386_I 1.982 0.99
184_K 188_L 1.853 0.98
355_G 360_P 1.844 0.98
236_I 254_G 1.817 0.98
209_E 250_K 1.8 0.98
264_K 362_E 1.797 0.98
274_I 359_L 1.769 0.98
216_D 232_W 1.753 0.97
172_L 181_L 1.749 0.97
277_L 281_E 1.735 0.97
351_Q 359_L 1.716 0.97
371_V 374_E 1.706 0.97
232_W 364_Y 1.64 0.96
332_N 336_R 1.609 0.95
367_T 370_V 1.587 0.95
120_D 145_K 1.547 0.94
167_I 170_S 1.526 0.93
363_I 386_I 1.506 0.92
263_I 365_A 1.466 0.91
52_A 60_L 1.465 0.91
401_P 405_D 1.465 0.91
330_Y 393_F 1.464 0.91
201_M 228_K 1.462 0.91
311_S 314_S 1.458 0.91
50_K 76_L 1.458 0.91
255_M 261_R 1.438 0.90
333_E 337_N 1.426 0.90
207_W 366_F 1.415 0.89
298_R 301_E 1.376 0.87
351_Q 383_F 1.366 0.87
390_V 395_L 1.364 0.87
303_N 307_R 1.363 0.86
299_H 303_N 1.361 0.86
305_W 318_L 1.346 0.86
366_F 372_W 1.344 0.85
116_F 149_A 1.335 0.85
341_I 367_T 1.322 0.84
333_E 336_R 1.315 0.84
231_N 237_T 1.307 0.83
362_E 376_E 1.305 0.83
263_I 341_I 1.296 0.82
331_L 361_L 1.295 0.82
300_Q 304_E 1.295 0.82
105_L 161_I 1.293 0.82
352_L 362_E 1.293 0.82
286_N 296_T 1.291 0.82
348_M 372_W 1.267 0.80
297_S 304_E 1.264 0.80
271_V 359_L 1.264 0.80
306_N 319_R 1.264 0.80
208_L 229_V 1.255 0.80
268_S 271_V 1.253 0.79
57_R 60_L 1.251 0.79
189_G 225_T 1.24 0.78
199_N 223_G 1.236 0.78
140_I 193_G 1.233 0.78
385_H 388_A 1.227 0.77
335_L 341_I 1.221 0.77
317_N 325_G 1.22 0.77
220_I 236_I 1.213 0.76
154_I 165_P 1.21 0.76
321_M 326_T 1.208 0.76
207_W 216_D 1.207 0.76
319_R 325_G 1.198 0.75
207_W 364_Y 1.194 0.75
209_E 216_D 1.194 0.75
342_R 370_V 1.194 0.75
57_R 61_Q 1.193 0.75
265_R 383_F 1.191 0.74
348_M 373_L 1.191 0.74
275_R 281_E 1.189 0.74
294_Y 325_G 1.188 0.74
105_L 109_M 1.184 0.74
348_M 364_Y 1.183 0.74
232_W 372_W 1.176 0.73
207_W 372_W 1.175 0.73
181_L 188_L 1.174 0.73
211_P 255_M 1.174 0.73
381_D 385_H 1.165 0.72
310_G 313_E 1.164 0.72
304_E 307_R 1.163 0.72
283_Q 388_A 1.161 0.72
292_K 296_T 1.16 0.72
223_G 241_T 1.153 0.71
270_D 399_Q 1.152 0.71
139_G 168_L 1.142 0.70
300_Q 314_S 1.134 0.69
312_T 315_V 1.132 0.69
232_W 366_F 1.123 0.68
298_R 326_T 1.122 0.68
98_I 151_L 1.119 0.68
309_Q 314_S 1.118 0.68
302_I 319_R 1.111 0.67
191_V 233_D 1.109 0.67
185_D 216_D 1.108 0.67
172_L 244_L 1.105 0.66
265_R 350_R 1.103 0.66
36_V 274_I 1.097 0.65
200_D 203_K 1.096 0.65
311_S 318_L 1.093 0.65
307_R 311_S 1.093 0.65
212_K 247_D 1.091 0.65
305_W 309_Q 1.091 0.65
281_E 285_L 1.087 0.64
347_L 359_L 1.087 0.64
261_R 366_F 1.085 0.64
112_L 148_G 1.084 0.64
367_T 378_I 1.083 0.64
341_I 382_I 1.082 0.64
174_A 177_A 1.081 0.64
299_H 321_M 1.081 0.64
52_A 61_Q 1.075 0.63
164_S 167_I 1.073 0.63
289_H 312_T 1.073 0.63
268_S 357_N 1.071 0.63
332_N 377_S 1.069 0.63
263_I 367_T 1.067 0.62
304_E 308_Q 1.066 0.62
296_T 300_Q 1.065 0.62
142_Q 185_D 1.065 0.62
406_I 409_L 1.064 0.62
297_S 404_N 1.059 0.61
267_I 397_L 1.058 0.61
211_P 214_G 1.057 0.61
271_V 397_L 1.055 0.61
301_E 319_R 1.055 0.61
279_E 387_F 1.055 0.61
305_W 308_Q 1.054 0.61
284_R 393_F 1.054 0.61
287_K 302_I 1.053 0.61
398_H 401_P 1.052 0.61
108_M 159_L 1.051 0.61
14_I 17_D 1.049 0.60
341_I 365_A 1.048 0.60
109_M 168_L 1.046 0.60
314_S 318_L 1.046 0.60
300_Q 303_N 1.045 0.60
44_V 79_I 1.044 0.60
292_K 299_H 1.043 0.60
192_A 195_Q 1.042 0.60
292_K 297_S 1.041 0.59
261_R 364_Y 1.04 0.59
364_Y 376_E 1.04 0.59
350_R 376_E 1.04 0.59
18_H 21_S 1.04 0.59
224_L 379_Q 1.04 0.59
230_R 386_I 1.039 0.59
277_L 295_L 1.037 0.59
201_M 244_L 1.036 0.59
192_A 231_N 1.036 0.59
308_Q 406_I 1.036 0.59
85_A 99_L 1.033 0.59
207_W 229_V 1.033 0.59
298_R 302_I 1.031 0.58
262_R 372_W 1.031 0.58
273_S 278_D 1.031 0.58
216_D 250_K 1.026 0.58
341_I 378_I 1.026 0.58
380_A 384_D 1.025 0.58
208_L 219_V 1.024 0.58
320_R 326_T 1.024 0.58
297_S 300_Q 1.023 0.57
185_D 207_W 1.023 0.57
262_R 366_F 1.022 0.57
302_I 409_L 1.022 0.57
361_L 386_I 1.02 0.57
244_L 255_M 1.017 0.57
185_D 188_L 1.016 0.57
255_M 375_Y 1.016 0.57
294_Y 317_N 1.016 0.57
300_Q 313_E 1.015 0.57
191_V 380_A 1.015 0.57
298_R 317_N 1.015 0.57
213_Y 243_S 1.015 0.57
311_S 315_V 1.014 0.56
255_M 376_E 1.014 0.56
230_R 234_N 1.014 0.56
293_P 297_S 1.012 0.56
391_E 394_G 1.011 0.56
309_Q 313_E 1.007 0.56
233_D 395_L 1.005 0.55
336_R 347_L 1.004 0.55
134_Q 245_V 1.003 0.55
174_A 179_L 1.002 0.55
17_D 22_M 1.001 0.55
310_G 314_S 1.001 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vv5A70.68431000.568Contact Map0.522
4hw9A70.71811000.574Contact Map0.552
3udcA70.66021000.59Contact Map0.448
1nz9A10.120548.90.967Contact Map0.337
2e6zA10.127747.60.968Contact Map0.445
4l5gA20.30627.20.972Contact Map0.395
3mlqE40.151825.10.972Contact Map0.624
2lt1A10.154220.70.973Contact Map0.308
2lt4A10.149420.40.973Contact Map0.217
3cnrA20.260213.80.975Contact Map0.14
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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