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OPENSEQ.org

THIO - Thioredoxin-1
UniProt: P0AA25 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11031
Length: 109 (105)
Sequences: 10210
Seq/Len: 97.24

THIO
Paralog alert: 0.85 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: THIO2 THIO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_E 97_K 2.516 1.00
87_V 90_T 2.393 1.00
49_E 101_K 2.339 1.00
8_L 57_A 2.213 1.00
101_K 105_D 2.196 1.00
89_A 103_F 2.048 1.00
14_D 70_K 2.038 1.00
71_Y 82_F 1.931 1.00
22_G 55_T 1.924 1.00
10_D 66_G 1.882 1.00
39_I 79_L 1.85 1.00
96_S 99_Q 1.848 1.00
61_I 76_I 1.742 1.00
23_A 83_K 1.707 1.00
50_Y 105_D 1.704 1.00
24_I 55_T 1.678 1.00
80_L 90_T 1.655 1.00
61_I 68_A 1.65 1.00
80_L 87_V 1.648 1.00
10_D 67_T 1.567 1.00
97_K 101_K 1.546 1.00
14_D 19_K 1.531 1.00
12_S 16_D 1.521 1.00
60_N 63_Q 1.447 1.00
27_D 58_K 1.433 1.00
42_I 45_E 1.433 1.00
33_C 36_C 1.393 0.99
50_Y 101_K 1.361 0.99
42_I 97_K 1.355 0.99
81_L 107_N 1.335 0.99
99_Q 102_E 1.326 0.99
9_T 12_S 1.318 0.99
25_L 43_L 1.259 0.99
49_E 97_K 1.258 0.99
43_L 56_V 1.256 0.99
103_F 106_A 1.25 0.99
40_A 58_K 1.23 0.98
10_D 64_N 1.196 0.98
82_F 87_V 1.194 0.98
81_L 103_F 1.19 0.98
38_M 94_A 1.187 0.98
28_F 71_Y 1.174 0.98
25_L 81_L 1.167 0.97
28_F 73_I 1.126 0.97
95_L 99_Q 1.125 0.97
31_E 60_N 1.108 0.96
26_V 82_F 1.102 0.96
8_L 16_D 1.099 0.96
103_F 107_N 1.09 0.96
15_T 19_K 1.083 0.96
91_K 95_L 1.072 0.95
98_G 102_E 1.071 0.95
23_A 81_L 1.065 0.95
89_A 107_N 1.036 0.94
91_K 103_F 1.023 0.93
16_D 55_T 1.017 0.93
89_A 106_A 1.016 0.93
4_K 48_D 1.009 0.93
27_D 39_I 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3f8uA20.972599.90.118Contact Map0.804
2r2jA10.990899.80.127Contact Map0.82
1thxA1199.80.129Contact Map0.845
4ekzA10.990899.80.135Contact Map0.752
3apoA10.990899.80.137Contact Map0.765
2b5eA10.990899.80.141Contact Map0.826
2o8vB1199.80.149Contact Map0.843
2qsiA20.981799.80.149Contact Map0.764
2qgvA100.990899.80.149Contact Map0.743
3dxbA8199.80.15Contact Map0.915

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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