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OPENSEQ.org

THIO2 - Thioredoxin-2
UniProt: P0AGG4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11887
Length: 139 (138)
Sequences: 1186
Seq/Len: 8.59

THIO2
Paralog alert: 0.62 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: THIO2 THIO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
91_N 94_A 5.162 1.00
40_A 88_V 3.002 1.00
46_D 101_R 2.78 1.00
42_G 98_L 2.627 1.00
62_P 91_N 2.602 1.00
76_D 128_K 2.469 1.00
81_R 136_N 2.258 1.00
53_L 86_R 2.137 1.00
56_V 112_I 1.981 1.00
118_V 121_M 1.946 1.00
53_L 83_G 1.935 1.00
74_F 87_F 1.905 1.00
56_V 87_F 1.835 1.00
42_G 97_E 1.8 1.00
46_D 50_K 1.755 1.00
58_D 66_P 1.698 1.00
80_E 132_D 1.661 1.00
127_P 130_P 1.644 1.00
132_D 136_N 1.643 1.00
111_M 121_M 1.64 1.00
41_T 44_T 1.64 1.00
92_T 107_I 1.591 1.00
111_M 118_V 1.566 1.00
58_D 89_K 1.532 1.00
48_L 55_V 1.528 1.00
112_I 138_S 1.507 1.00
130_P 133_S 1.499 1.00
120_D 134_W 1.445 0.99
57_I 113_F 1.414 0.99
59_F 102_F 1.407 0.99
42_G 95_E 1.39 0.99
110_I 122_L 1.323 0.99
126_V 130_P 1.315 0.99
64_C 67_C 1.27 0.98
60_W 107_I 1.25 0.98
105_R 121_M 1.22 0.98
77_V 87_F 1.211 0.97
24_K 29_G 1.203 0.97
80_E 128_K 1.2 0.97
36_E 79_Q 1.198 0.97
90_V 98_L 1.187 0.97
75_E 89_K 1.161 0.96
4_V 11_I 1.159 0.96
39_N 75_E 1.152 0.96
18_R 21_D 1.15 0.96
2_N 11_I 1.127 0.96
112_I 135_L 1.122 0.95
58_D 64_C 1.095 0.95
81_R 134_W 1.094 0.94
102_F 113_F 1.093 0.94
81_R 132_D 1.085 0.94
56_V 135_L 1.076 0.94
92_T 104_I 1.075 0.94
56_V 85_V 1.074 0.94
58_D 63_W 1.067 0.93
59_F 92_T 1.066 0.93
47_K 50_K 1.063 0.93
52_D 115_N 1.06 0.93
41_T 95_E 1.048 0.93
98_L 102_F 1.04 0.92
63_W 66_P 1.039 0.92
77_V 123_N 1.037 0.92
63_W 93_E 1.032 0.92
62_P 107_I 1.027 0.92
70_F 110_I 1.022 0.91
126_V 134_W 1.022 0.91
7_H 30_H 1.02 0.91
38_I 86_R 1.02 0.91
59_F 111_M 1.013 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2pptA20.99281000.367Contact Map0.751
3p2aA40.99281000.444Contact Map0.824
1v98A20.98561000.463Contact Map0.723
3f8uA20.75541000.474Contact Map0.756
3bj5A10.82011000.482Contact Map0.546
2r2jA10.78421000.483Contact Map0.741
4ekzA10.94241000.485Contact Map0.675
2b5eA10.827399.90.494Contact Map0.74
2qgvA100.863399.90.495Contact Map0.654
2qsiA20.812999.90.495Contact Map0.636

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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