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OPENSEQ.org

PTHP - Phosphocarrier protein HPr
UniProt: P0AA04 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10788
Length: 85 (83)
Sequences: 1795
Seq/Len: 21.63

PTHP
Paralog alert: 0.51 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: PTHP PTSO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_E 60_V 3.111 1.00
65_A 74_V 2.593 1.00
31_S 69_D 2.482 1.00
30_T 68_E 2.329 1.00
6_V 78_V 2.128 1.00
4_Q 78_V 2.058 1.00
22_F 77_L 2.005 1.00
3_Q 62_T 1.971 1.00
71_Q 75_E 1.951 1.00
29_F 76_H 1.923 1.00
25_E 28_G 1.907 1.00
30_T 69_D 1.822 1.00
3_Q 64_S 1.798 1.00
78_V 82_A 1.779 1.00
7_T 60_V 1.754 1.00
25_E 76_H 1.719 1.00
34_T 41_S 1.695 1.00
37_S 59_T 1.695 1.00
5_E 62_T 1.563 1.00
29_F 73_A 1.539 1.00
75_E 79_K 1.514 1.00
36_T 64_S 1.466 1.00
36_T 41_S 1.453 1.00
41_S 64_S 1.412 1.00
36_T 62_T 1.395 0.99
2_F 74_V 1.376 0.99
2_F 71_Q 1.349 0.99
1_M 70_E 1.345 0.99
22_F 44_A 1.34 0.99
69_D 72_K 1.283 0.99
79_K 83_E 1.269 0.99
42_A 53_L 1.234 0.98
72_K 76_H 1.227 0.98
4_Q 75_E 1.208 0.98
11_P 57_Q 1.189 0.98
55_L 61_V 1.17 0.97
32_E 66_E 1.119 0.96
2_F 70_E 1.111 0.96
33_I 73_A 1.095 0.96
72_K 75_E 1.083 0.96
22_F 35_V 1.08 0.95
36_T 39_G 1.079 0.95
9_T 82_A 1.036 0.94
26_A 77_L 1.023 0.93
42_A 48_F 1.021 0.93
56_T 59_T 1.013 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ccdA2199.90.044Contact Map0.826
1ka5A1199.90.06Contact Map0.821
1kklH3199.90.061Contact Map0.845
3ihsA20.964799.90.065Contact Map0.829
1ptfA1199.90.066Contact Map0.771
1sphA2199.90.069Contact Map0.845
1y51A3199.90.07Contact Map0.743
3le1A2199.90.073Contact Map0.84
1pchA10.988299.90.095Contact Map0.777
2jpiA10.905941.70.871Contact Map0.139

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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