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OPENSEQ.org

PUUR - HTH-type transcriptional regulator PuuR
UniProt: P0A9U6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12431
Length: 185 (180)
Sequences: 2521
Seq/Len: 14.01

PUUR
Paralog alert: 0.63 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: PUUR YDCN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
136_E 175_R 4.266 1.00
138_E 151_V 3.798 1.00
139_I 174_C 2.926 1.00
140_V 167_S 2.924 1.00
140_V 147_D 2.841 1.00
138_E 149_H 2.485 1.00
136_E 152_A 2.435 1.00
140_V 149_H 2.426 1.00
140_V 169_T 2.4 1.00
111_F 175_R 2.389 1.00
24_R 28_E 2.217 1.00
25_R 29_L 2.193 1.00
23_Q 37_I 2.186 1.00
141_L 156_Y 2.169 1.00
124_I 128_G 2.146 1.00
15_I 61_L 2 1.00
85_L 96_K 1.979 1.00
14_E 18_Q 1.937 1.00
150_L 154_Q 1.914 1.00
144_N 162_I 1.882 1.00
109_M 131_I 1.874 1.00
115_Q 173_I 1.8 1.00
81_N 154_Q 1.789 1.00
33_T 36_A 1.701 1.00
113_T 175_R 1.686 1.00
130_E 164_H 1.675 1.00
24_R 34_H 1.668 1.00
113_T 173_I 1.64 1.00
124_I 127_Q 1.637 1.00
36_A 40_I 1.617 1.00
25_R 28_E 1.613 1.00
21_L 29_L 1.599 1.00
32_L 51_T 1.507 1.00
135_L 177_I 1.504 1.00
142_T 167_S 1.501 1.00
139_I 176_I 1.494 1.00
38_S 42_Q 1.466 1.00
107_L 157_A 1.454 1.00
109_M 179_A 1.448 1.00
136_E 173_I 1.431 1.00
40_I 47_P 1.429 1.00
142_T 145_G 1.429 1.00
126_H 164_H 1.422 1.00
26_A 58_V 1.394 0.99
26_A 59_Y 1.385 0.99
32_L 36_A 1.379 0.99
126_H 130_E 1.373 0.99
143_I 162_I 1.364 0.99
35_S 38_S 1.333 0.99
142_T 147_D 1.317 0.99
116_P 168_N 1.29 0.99
81_N 84_D 1.285 0.99
79_V 156_Y 1.284 0.99
131_I 155_S 1.279 0.99
119_T 165_S 1.278 0.99
125_K 128_G 1.275 0.99
36_A 51_T 1.273 0.99
132_G 156_Y 1.266 0.99
158_I 164_H 1.246 0.98
21_L 26_A 1.243 0.98
82_Q 154_Q 1.237 0.98
138_E 170_S 1.236 0.98
16_R 41_E 1.212 0.98
96_K 113_T 1.2 0.98
136_E 172_G 1.193 0.98
134_V 174_C 1.188 0.98
95_M 99_H 1.179 0.98
119_T 167_S 1.172 0.98
114_Y 176_I 1.166 0.97
37_I 55_L 1.153 0.97
36_A 39_T 1.144 0.97
133_T 177_I 1.143 0.97
96_K 111_F 1.134 0.97
56_L 61_L 1.134 0.97
13_S 17_Q 1.124 0.97
114_Y 118_T 1.108 0.96
62_S 65_E 1.107 0.96
9_G 43_D 1.099 0.96
23_Q 38_S 1.095 0.96
142_T 165_S 1.09 0.96
116_P 172_G 1.081 0.95
12_L 55_L 1.079 0.95
82_Q 152_A 1.062 0.95
7_A 43_D 1.039 0.94
132_G 178_S 1.038 0.94
93_V 100_N 1.029 0.94
129_E 157_A 1.025 0.93
53_Q 63_L 1.022 0.93
36_A 45_V 1.019 0.93
11_R 14_E 1.017 0.93
111_F 133_T 1.016 0.93
151_V 154_Q 1.01 0.93
170_S 174_C 1.007 0.93
30_S 58_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1y9qA10.94591000.362Contact Map0.701
2bnmA20.97841000.373Contact Map0.67
3g7dA10.97841000.382Contact Map0.606
2p5tA40.848699.90.502Contact Map0.064
1j58A10.82799.90.536Contact Map0.519
4b29A10.983899.80.583Contact Map0.538
3bu7A20.956899.80.616Contact Map0.445
1rc6A20.718999.70.637Contact Map0.609
3ivpA40.654199.70.649Contact Map0.71
1sefA10.735199.70.651Contact Map0.665

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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