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OPENSEQ.org
DEAD - Cold-shock DEAD box protein A
UniProt: P0A9P6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10215
Length: 629 (548)
Sequences: 932
Seq/Len: 1.70
DEAD
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: DBPA DEAD RHLB RHLE SRMB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
131_G 145_L 4.23 1.00
61_S 94_M 4.121 1.00
139_H 144_T 3.867 1.00
64_L 77_I 3.461 1.00
14_K 66_Q 3.301 1.00
137_L 141_K 3.211 1.00
23_D 100_H 3.022 1.00
44_R 206_Q 2.866 1.00
137_L 140_L 2.582 1.00
255_K 278_D 2.543 1.00
17_I 66_Q 2.527 1.00
39_H 208_V 2.455 1.00
131_G 136_L 2.435 1.00
137_L 172_T 2.414 1.00
32_I 48_G 2.322 1.00
221_S 369_P 2.311 1.00
153_L 174_M 2.192 0.99
79_V 94_M 2.158 0.99
13_L 62_L 2.137 0.99
26_Y 97_F 2.108 0.99
550_I 555_M 2.049 0.99
258_T 276_N 2.028 0.99
107_V 126_P 1.976 0.98
221_S 344_R 1.938 0.98
505_V 519_I 1.935 0.98
491_I 504_I 1.931 0.98
222_Q 333_I 1.908 0.98
499_V 504_I 1.893 0.98
313_R 341_R 1.889 0.98
197_I 201_F 1.861 0.97
500_E 503_H 1.838 0.97
115_Y 144_T 1.806 0.97
255_K 276_N 1.772 0.96
15_A 19_E 1.764 0.96
172_T 176_Q 1.76 0.96
322_I 347_L 1.707 0.95
252_V 258_T 1.694 0.95
503_H 551_L 1.687 0.94
497_D 553_K 1.68 0.94
70_P 127_Q 1.656 0.94
253_R 316_L 1.644 0.93
233_N 261_V 1.644 0.93
30_S 249_I 1.644 0.93
506_G 510_N 1.638 0.93
78_L 150_L 1.628 0.93
289_E 293_D 1.6 0.92
74_A 149_K 1.593 0.92
80_L 136_L 1.588 0.92
136_L 145_L 1.583 0.92
232_K 534_P 1.557 0.91
9_A 22_N 1.546 0.90
39_H 206_Q 1.537 0.90
69_D 127_Q 1.523 0.89
141_K 172_T 1.52 0.89
65_L 101_M 1.496 0.88
43_G 182_Q 1.485 0.88
8_F 29_P 1.468 0.87
142_R 275_L 1.447 0.86
23_D 99_K 1.443 0.86
508_I 519_I 1.439 0.86
420_D 423_T 1.436 0.85
76_Q 127_Q 1.433 0.85
505_V 509_A 1.429 0.85
262_A 274_A 1.417 0.84
239_F 316_L 1.416 0.84
174_M 177_I 1.411 0.84
39_H 42_N 1.404 0.84
202_M 309_L 1.395 0.83
506_G 511_E 1.392 0.83
120_R 142_R 1.383 0.82
291_L 299_L 1.379 0.82
64_L 152_G 1.375 0.82
77_I 94_M 1.369 0.81
19_E 100_H 1.366 0.81
258_T 274_A 1.366 0.81
113_Q 139_H 1.353 0.80
238_R 241_E 1.349 0.80
115_Y 142_R 1.347 0.80
160_E 163_R 1.346 0.80
491_I 529_S 1.344 0.80
30_S 255_K 1.33 0.79
239_F 249_I 1.323 0.78
489_Y 533_L 1.319 0.78
239_F 346_L 1.317 0.78
77_I 347_L 1.311 0.77
392_Q 410_I 1.309 0.77
258_T 262_A 1.308 0.77
108_A 268_N 1.307 0.77
219_D 342_A 1.304 0.77
195_R 207_E 1.302 0.77
261_V 300_I 1.302 0.77
243_E 315_S 1.301 0.77
26_Y 61_S 1.3 0.77
109_L 139_H 1.299 0.77
35_E 208_V 1.296 0.76
506_G 509_A 1.291 0.76
35_E 206_Q 1.291 0.76
538_P 542_L 1.289 0.76
45_D 181_H 1.282 0.75
45_D 205_P 1.28 0.75
507_A 511_E 1.28 0.75
210_I 272_S 1.278 0.75
490_R 530_T 1.276 0.75
77_I 152_G 1.275 0.75
202_M 253_R 1.275 0.75
140_L 150_L 1.271 0.74
217_R 220_I 1.265 0.74
216_T 330_V 1.263 0.74
387_F 429_L 1.257 0.73
168_E 256_N 1.254 0.73
12_G 18_L 1.251 0.73
235_A 373_L 1.245 0.72
485_D 535_K 1.243 0.72
88_V 108_A 1.24 0.72
167_I 202_M 1.24 0.72
73_K 127_Q 1.234 0.71
501_V 522_I 1.234 0.71
319_N 333_I 1.232 0.71
411_Q 424_L 1.231 0.71
27_E 268_N 1.228 0.71
285_E 288_L 1.224 0.70
68_L 173_I 1.223 0.70
129_V 145_L 1.209 0.69
357_L 360_I 1.209 0.69
237_V 267_R 1.208 0.69
326_S 363_T 1.207 0.69
30_S 322_I 1.2 0.68
322_I 360_I 1.198 0.68
253_R 345_A 1.194 0.68
245_F 248_A 1.192 0.67
153_L 201_F 1.192 0.67
40_L 184_A 1.191 0.67
75_P 145_L 1.19 0.67
236_L 250_I 1.185 0.67
361_E 367_T 1.18 0.66
485_D 488_L 1.18 0.66
46_V 442_P 1.175 0.66
239_F 318_V 1.174 0.66
29_P 315_S 1.169 0.65
223_S 371_V 1.169 0.65
253_R 315_S 1.168 0.65
119_L 139_H 1.158 0.64
544_H 548_T 1.158 0.64
98_S 311_V 1.155 0.64
81_A 174_M 1.151 0.63
232_K 321_D 1.151 0.63
242_A 379_L 1.15 0.63
90_V 330_V 1.146 0.63
265_L 492_E 1.142 0.62
294_G 341_R 1.141 0.62
146_D 149_K 1.138 0.62
172_T 175_A 1.137 0.62
224_Y 370_E 1.134 0.62
21_L 421_L 1.127 0.61
237_V 268_N 1.125 0.61
163_R 170_V 1.122 0.60
192_E 196_R 1.122 0.60
273_A 290_R 1.115 0.60
391_V 431_M 1.112 0.59
198_T 220_I 1.111 0.59
119_L 144_T 1.109 0.59
347_L 533_L 1.108 0.59
240_L 248_A 1.105 0.59
253_R 328_S 1.101 0.58
270_Y 298_I 1.099 0.58
515_S 518_Y 1.098 0.58
234_E 255_K 1.096 0.58
205_P 287_T 1.096 0.58
19_E 23_D 1.094 0.58
410_I 414_A 1.093 0.57
525_F 530_T 1.086 0.57
322_I 377_E 1.085 0.57
222_Q 319_N 1.083 0.56
389_A 393_Q 1.083 0.56
26_Y 519_I 1.082 0.56
45_D 183_T 1.082 0.56
88_V 168_E 1.081 0.56
259_L 276_N 1.079 0.56
91_A 108_A 1.076 0.56
247_A 314_I 1.075 0.56
258_T 347_L 1.073 0.55
348_F 379_L 1.069 0.55
241_E 270_Y 1.068 0.55
273_A 296_L 1.068 0.55
72_L 75_P 1.068 0.55
120_R 123_R 1.065 0.54
508_I 514_I 1.063 0.54
473_E 482_D 1.062 0.54
279_M 288_L 1.059 0.54
216_T 360_I 1.057 0.54
177_I 181_H 1.056 0.54
486_M 509_A 1.055 0.53
17_I 553_K 1.054 0.53
545_F 557_M 1.051 0.53
32_I 94_M 1.043 0.52
482_D 488_L 1.043 0.52
489_Y 537_M 1.042 0.52
163_R 167_I 1.041 0.52
47_L 190_M 1.04 0.52
67_N 151_S 1.04 0.52
299_L 309_L 1.04 0.52
246_D 315_S 1.038 0.52
150_L 175_A 1.036 0.51
279_M 285_E 1.035 0.51
190_M 327_E 1.034 0.51
171_E 200_R 1.034 0.51
309_L 524_L 1.033 0.51
455_R 472_R 1.03 0.51
97_F 366_L 1.03 0.51
495_R 501_V 1.029 0.51
179_E 203_K 1.024 0.50
150_L 163_R 1.023 0.50
49_M 181_H 1.023 0.50
539_G 559_L 1.019 0.50
388_A 391_V 1.018 0.49
496_D 527_S 1.013 0.49
213_S 391_V 1.012 0.49
79_V 128_I 1.008 0.48
154_V 202_M 1.008 0.48
533_L 538_P 1.006 0.48
546_T 557_M 1.006 0.48
95_T 104_V 1.004 0.48
31_P 153_L 1.004 0.48
193_A 375_N 1.001 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3sqwA10.79331000.602Contact Map0.476
3i5xA10.73291000.606Contact Map0.496
2db3A40.59781000.628Contact Map0.602
3fmpB20.60571000.642Contact Map0.663
4c9bA10.6011000.65Contact Map0.576
3eiqA20.6011000.65Contact Map0.526
2j0sA10.6011000.651Contact Map0.565
2i4iA10.61211000.657Contact Map0.55
3fhtA20.60571000.665Contact Map0.561
1xtiA10.60731000.671Contact Map0.621
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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