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OPENSEQ.org
FKBB - FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase
UniProt: P0A9L3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12503
Length: 206 (202)
Sequences: 794
Seq/Len: 3.93
FKBB
Paralog alert: 0.74 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: FKBA FKBB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
107_R 172_E 3.535 1.00
91_N 105_Q 3.244 1.00
161_A 173_L 3.118 1.00
116_I 166_P 3.113 1.00
128_T 136_V 2.977 1.00
150_P 153_G 2.968 1.00
167_V 205_I 2.871 1.00
85_V 89_E 2.849 1.00
128_T 141_V 2.696 1.00
82_A 86_K 2.572 1.00
161_A 171_W 2.492 1.00
166_P 169_S 2.471 1.00
136_V 142_A 2.443 1.00
131_L 135_T 2.418 1.00
87_Y 174_T 2.394 1.00
191_P 194_S 2.224 1.00
124_R 204_E 2.169 1.00
177_Q 193_F 2.143 1.00
120_T 152_N 2.107 1.00
124_R 146_P 2.095 1.00
151_V 161_A 2.004 1.00
146_P 203_L 1.986 1.00
11_A 34_L 1.961 1.00
104_L 179_L 1.936 1.00
170_K 201_E 1.915 1.00
124_R 148_E 1.91 1.00
99_S 105_Q 1.909 1.00
107_R 174_T 1.887 1.00
173_L 200_V 1.81 1.00
140_S 143_R 1.801 0.99
183_E 193_F 1.797 0.99
167_V 204_E 1.77 0.99
86_K 90_E 1.753 0.99
170_K 199_E 1.735 0.99
100_T 171_W 1.72 0.99
109_I 172_E 1.66 0.99
172_E 199_E 1.6 0.99
165_M 171_W 1.575 0.98
84_G 195_T 1.566 0.98
92_A 99_S 1.555 0.98
19_L 51_P 1.549 0.98
117_P 202_L 1.547 0.98
119_R 163_T 1.543 0.98
88_L 91_N 1.523 0.98
162_L 173_L 1.505 0.98
81_A 84_G 1.477 0.97
94_K 107_R 1.447 0.97
57_V 60_R 1.443 0.97
102_S 160_E 1.439 0.97
118_A 152_N 1.346 0.94
91_N 94_K 1.345 0.94
91_N 99_S 1.338 0.94
90_E 94_K 1.313 0.93
41_G 45_A 1.295 0.93
115_A 167_V 1.284 0.92
9_I 12_Q 1.279 0.92
156_P 159_I 1.278 0.92
132_I 195_T 1.268 0.92
129_G 137_F 1.251 0.91
116_I 169_S 1.247 0.91
36_E 43_A 1.246 0.91
68_R 72_V 1.245 0.91
156_P 178_E 1.243 0.91
151_V 162_L 1.241 0.91
44_D 52_A 1.237 0.90
80_M 83_E 1.226 0.90
157_G 175_I 1.223 0.90
125_V 158_W 1.221 0.90
166_P 171_W 1.217 0.89
54_P 57_V 1.217 0.89
108_V 171_W 1.215 0.89
88_L 105_Q 1.203 0.89
83_E 133_D 1.189 0.88
126_H 143_R 1.187 0.88
94_K 105_Q 1.18 0.87
35_P 39_V 1.173 0.87
23_Q 55_V 1.155 0.86
89_E 93_K 1.154 0.86
139_S 143_R 1.143 0.85
159_I 163_T 1.143 0.85
111_Q 169_S 1.142 0.85
128_T 199_E 1.137 0.85
119_R 152_N 1.133 0.84
126_H 141_V 1.13 0.84
132_I 197_V 1.13 0.84
148_E 206_L 1.128 0.84
126_H 203_L 1.127 0.84
124_R 206_L 1.118 0.83
83_E 86_K 1.114 0.83
90_E 93_K 1.103 0.82
185_G 194_S 1.099 0.82
165_M 169_S 1.091 0.81
122_R 150_P 1.061 0.79
136_V 141_V 1.057 0.78
126_H 201_E 1.044 0.77
75_Q 78_Q 1.043 0.77
164_L 171_W 1.034 0.76
130_K 136_V 1.03 0.76
100_T 164_L 1.02 0.75
104_L 164_L 1.017 0.74
100_T 160_E 1.014 0.74
81_A 191_P 1.013 0.74
126_H 140_S 1.006 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1fd9A10.99511000.248Contact Map0.701
3oe2A10.98061000.262Contact Map0.745
1q6hA20.98541000.276Contact Map0.732
1jvwA10.67961000.472Contact Map0.727
2jwxA10.64561000.505Contact Map0.535
3uf8A10.94171000.534Contact Map0.607
2f4eA20.72331000.535Contact Map0.648
4driA10.66021000.559Contact Map0.674
3jxvA10.55831000.559Contact Map
2lgoA10.61651000.562Contact Map0.544
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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