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FKBA - FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
UniProt: P45523 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12900
Length: 270 (256)
Sequences: 312
Seq/Len: 1.22
FKBA
Paralog alert: 0.09 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FKBA FKBB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
135_F 149_V 3.214 1.00
126_A 130_E 2.738 1.00
175_L 179_K 2.711 1.00
172_K 180_E 2.67 1.00
151_Q 216_K 2.608 1.00
211_K 248_V 2.569 1.00
143_T 149_V 2.464 0.99
148_L 223_L 2.436 0.99
184_S 187_R 2.382 0.99
172_K 185_Y 2.314 0.99
160_A 210_K 2.308 0.99
205_G 215_I 2.148 0.98
205_G 217_L 2.116 0.98
210_K 213_G 2.071 0.98
180_E 186_T 2.033 0.97
131_Y 218_V 1.95 0.96
132_R 135_F 1.829 0.94
125_E 129_K 1.827 0.94
172_K 242_D 1.795 0.93
132_R 149_V 1.765 0.93
190_P 246_L 1.759 0.92
46_Q 75_D 1.748 0.92
161_P 245_L 1.714 0.91
214_K 242_D 1.687 0.90
209_I 215_I 1.671 0.90
124_N 128_G 1.628 0.88
129_K 133_E 1.604 0.87
151_Q 218_V 1.59 0.86
123_D 127_K 1.573 0.86
198_V 203_T 1.509 0.82
195_L 205_G 1.509 0.82
214_K 244_E 1.499 0.82
209_I 213_G 1.482 0.81
128_G 238_T 1.476 0.80
170_N 244_E 1.474 0.80
183_N 187_R 1.448 0.78
130_E 134_K 1.435 0.78
123_D 136_A 1.43 0.77
135_F 138_E 1.426 0.77
210_K 215_I 1.425 0.77
132_R 221_P 1.42 0.77
163_D 207_K 1.419 0.76
8_T 11_A 1.379 0.74
138_E 149_V 1.37 0.73
10_L 16_V 1.33 0.70
148_L 208_N 1.328 0.69
198_V 243_V 1.326 0.69
168_V 190_P 1.301 0.67
144_S 215_I 1.29 0.66
142_K 160_A 1.289 0.66
142_K 152_V 1.278 0.65
176_I 240_V 1.272 0.65
135_F 143_T 1.271 0.65
170_N 184_S 1.265 0.64
1_M 6_K 1.265 0.64
169_V 202_W 1.262 0.64
234_P 237_S 1.256 0.63
217_L 243_V 1.25 0.63
115_A 119_K 1.247 0.62
187_R 244_E 1.232 0.61
174_T 180_E 1.23 0.61
74_L 136_A 1.227 0.61
206_L 217_L 1.218 0.60
100_Q 162_K 1.216 0.60
6_K 11_A 1.206 0.59
194_R 197_G 1.205 0.58
170_N 187_R 1.202 0.58
17_A 29_A 1.2 0.58
211_K 247_D 1.195 0.58
182_D 243_V 1.192 0.57
201_G 219_I 1.191 0.57
82_G 110_K 1.19 0.57
97_E 100_Q 1.187 0.57
119_K 123_D 1.186 0.57
170_N 246_L 1.182 0.56
49_A 203_T 1.179 0.56
82_G 86_A 1.177 0.56
193_F 202_W 1.162 0.54
180_E 185_Y 1.161 0.54
139_K 222_E 1.145 0.53
21_P 24_F 1.144 0.53
170_N 185_Y 1.142 0.52
184_S 243_V 1.132 0.51
136_A 143_T 1.128 0.51
114_Q 118_E 1.117 0.50
55_S 59_Y 1.115 0.50
15_A 28_A 1.114 0.50
170_N 190_P 1.113 0.50
102_L 109_V 1.11 0.49
183_N 202_W 1.109 0.49
134_K 138_E 1.106 0.49
126_A 129_K 1.104 0.49
32_A 35_A 1.104 0.49
168_V 192_S 1.1 0.48
164_S 196_D 1.086 0.47
8_T 14_M 1.075 0.46
203_T 207_K 1.069 0.45
171_Y 182_D 1.068 0.45
77_D 179_K 1.068 0.45
216_K 242_D 1.063 0.45
187_R 198_V 1.055 0.44
4_L 8_T 1.051 0.44
202_W 233_I 1.045 0.43
169_V 223_L 1.045 0.43
144_S 208_N 1.038 0.42
181_F 199_I 1.037 0.42
76_K 80_I 1.026 0.41
1_M 8_T 1.024 0.41
121_A 236_N 1.022 0.41
135_F 218_V 1.021 0.41
229_G 237_S 1.021 0.41
120_D 123_D 1.018 0.40
152_V 215_I 1.016 0.40
20_A 23_T 1.016 0.40
144_S 148_L 1.013 0.40
204_E 238_T 1.013 0.40
124_N 127_K 1.003 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1q6hA20.82961000.354Contact Map0.628
1fd9A10.78151000.368Contact Map0.635
3oe2A10.80371000.394Contact Map0.678
1jvwA10.59261000.567Contact Map0.638
2jwxA10.52591000.593Contact Map0.476
2f4eA20.62591000.604Contact Map0.585
3uf8A10.75191000.61Contact Map0.478
4driA10.50741000.638Contact Map0.607
4bf8A10.42591000.64Contact Map0.517
4drjA10.50741000.642Contact Map0.605
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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