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OPENSEQ.org
WZA - Putative polysaccharide export protein wza
UniProt: P0A930 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13566
Length: 379 (378)
Sequences: 454
Seq/Len: 1.20
WZA
Paralog alert: 0.37 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GFCE WZA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
87_V 144_I 6.055 1.00
87_V 120_V 3.669 1.00
136_V 144_I 2.613 1.00
54_P 319_Q 2.342 0.99
139_K 147_D 2.306 0.99
297_G 348_P 2.073 0.98
18_I 21_C 1.892 0.95
21_C 25_P 1.891 0.95
366_V 372_T 1.873 0.95
298_I 346_T 1.779 0.93
229_L 280_E 1.719 0.91
86_R 143_E 1.707 0.91
9_M 12_L 1.673 0.90
194_I 247_L 1.673 0.90
299_F 318_Y 1.605 0.87
99_D 338_P 1.59 0.86
121_Q 125_T 1.582 0.86
256_K 280_E 1.581 0.86
297_G 345_T 1.549 0.84
174_Y 199_N 1.512 0.82
195_L 238_N 1.506 0.82
139_K 144_I 1.464 0.79
148_I 244_G 1.463 0.79
163_V 318_Y 1.453 0.78
120_V 186_A 1.45 0.78
144_I 163_V 1.42 0.76
281_A 336_L 1.419 0.76
105_T 277_T 1.417 0.76
55_L 59_L 1.411 0.75
279_T 331_A 1.398 0.75
197_A 241_L 1.397 0.74
225_S 240_L 1.386 0.74
366_V 374_S 1.382 0.73
6_M 10_P 1.37 0.72
131_I 158_D 1.366 0.72
2_M 5_K 1.353 0.71
262_E 354_R 1.346 0.70
85_Y 101_P 1.339 0.70
241_L 247_L 1.337 0.70
86_R 140_T 1.329 0.69
294_N 321_D 1.329 0.69
6_M 12_L 1.326 0.69
300_V 320_L 1.324 0.69
374_S 377_H 1.311 0.68
263_V 344_V 1.306 0.67
269_L 276_M 1.293 0.66
5_K 9_M 1.291 0.66
11_L 14_S 1.291 0.66
55_L 320_L 1.29 0.66
97_V 320_L 1.285 0.65
374_S 378_N 1.283 0.65
149_T 161_V 1.271 0.64
352_W 356_I 1.267 0.64
134_V 198_I 1.264 0.63
103_L 106_P 1.26 0.63
275_G 348_P 1.256 0.63
367_R 375_D 1.247 0.62
127_F 145_R 1.24 0.61
143_E 163_V 1.237 0.61
217_H 242_Y 1.235 0.61
353_N 357_N 1.233 0.61
165_I 259_V 1.232 0.60
16_T 41_D 1.221 0.59
148_I 163_V 1.218 0.59
1_M 7_K 1.216 0.59
137_V 325_A 1.212 0.59
341_V 349_V 1.209 0.58
100_H 191_P 1.207 0.58
88_G 170_S 1.199 0.57
321_D 357_N 1.199 0.57
88_G 278_L 1.197 0.57
7_K 12_L 1.194 0.57
153_A 337_Q 1.192 0.57
98_W 158_D 1.192 0.57
364_S 370_T 1.181 0.56
26_G 35_D 1.179 0.55
20_G 301_I 1.175 0.55
242_Y 294_N 1.174 0.55
2_M 12_L 1.173 0.55
2_M 9_M 1.171 0.55
289_D 293_S 1.168 0.54
204_L 229_L 1.167 0.54
54_P 321_D 1.164 0.54
288_I 298_I 1.16 0.54
140_T 240_L 1.159 0.54
177_G 201_A 1.157 0.53
328_L 355_L 1.153 0.53
11_L 143_E 1.149 0.53
182_S 283_G 1.148 0.52
3_K 6_M 1.146 0.52
294_N 323_S 1.139 0.52
81_A 221_E 1.139 0.52
193_T 279_T 1.138 0.51
95_V 148_I 1.137 0.51
89_P 288_I 1.135 0.51
215_L 271_M 1.134 0.51
146_S 150_G 1.13 0.51
224_I 357_N 1.129 0.51
5_K 13_V 1.129 0.51
182_S 248_Y 1.129 0.51
12_L 32_M 1.126 0.50
7_K 10_P 1.125 0.50
368_Y 374_S 1.121 0.50
154_T 158_D 1.118 0.50
372_T 375_D 1.117 0.49
86_R 171_Q 1.117 0.49
59_L 259_V 1.116 0.49
144_I 147_D 1.113 0.49
95_V 149_T 1.111 0.49
198_I 223_R 1.105 0.48
63_L 136_V 1.101 0.48
258_F 280_E 1.096 0.47
277_T 291_T 1.096 0.47
66_R 341_V 1.095 0.47
6_M 9_M 1.095 0.47
118_N 356_I 1.092 0.47
33_G 377_H 1.092 0.47
256_K 284_N 1.092 0.47
95_V 300_V 1.09 0.47
108_G 198_I 1.089 0.47
367_R 371_D 1.089 0.47
92_V 159_P 1.089 0.47
179_V 203_G 1.087 0.47
140_T 143_E 1.085 0.46
10_P 14_S 1.082 0.46
5_K 12_L 1.081 0.46
104_T 235_L 1.078 0.46
52_V 298_I 1.076 0.45
88_G 100_H 1.074 0.45
300_V 334_F 1.074 0.45
9_M 14_S 1.067 0.45
312_G 366_V 1.066 0.45
46_L 265_K 1.064 0.44
12_L 15_V 1.064 0.44
10_P 288_I 1.064 0.44
85_Y 259_V 1.062 0.44
130_Y 253_D 1.062 0.44
105_T 217_H 1.061 0.44
101_P 241_L 1.061 0.44
134_V 356_I 1.059 0.44
7_K 11_L 1.058 0.44
60_I 330_M 1.056 0.44
288_I 322_M 1.054 0.43
6_M 32_M 1.05 0.43
60_I 146_S 1.048 0.43
5_K 10_P 1.048 0.43
102_E 117_G 1.047 0.43
12_L 375_D 1.044 0.42
8_L 33_G 1.044 0.42
97_V 100_H 1.042 0.42
56_T 87_V 1.041 0.42
69_V 232_N 1.038 0.42
6_M 33_G 1.038 0.42
12_L 17_L 1.038 0.42
103_L 233_G 1.037 0.42
105_T 255_L 1.034 0.41
216_T 221_E 1.032 0.41
28_N 343_Y 1.031 0.41
366_V 375_D 1.029 0.41
8_L 12_L 1.029 0.41
27_S 347_A 1.024 0.41
371_D 374_S 1.022 0.40
12_L 69_V 1.021 0.40
120_V 333_E 1.02 0.40
290_M 346_T 1.019 0.40
156_I 193_T 1.018 0.40
70_A 190_V 1.017 0.40
188_T 196_D 1.016 0.40
355_L 359_L 1.015 0.40
20_G 25_P 1.015 0.40
341_V 355_L 1.012 0.39
145_R 320_L 1.012 0.39
112_S 308_G 1.012 0.39
44_F 298_I 1.01 0.39
104_T 108_G 1.008 0.39
167_A 249_V 1.006 0.39
199_N 258_F 1.004 0.39
50_V 317_I 1.002 0.38
131_I 148_I 1.002 0.38
179_V 202_G 1.001 0.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2j58A80.9421000.294Contact Map0.449
3p42A40.48551000.73Contact Map0.193
3zbiC140.126652.90.967Contact Map0
3abfA60.153190.974Contact Map0.471
1i9gA10.3615160.975Contact Map0.187
3m20A30.150413.90.976Contact Map0.414
3mb5A10.345613.70.976Contact Map0.178
2kzfA10.234810.60.977Contact Map0.179
2pptA20.35888.90.978Contact Map0.26
2pwyA20.35628.40.978Contact Map0.063
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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