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SLYA - Transcriptional regulator SlyA
UniProt: P0A8W2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13408
Length: 144 (137)
Sequences: 9327
Seq/Len: 68.08

SLYA
Paralog alert: 0.89 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: MARR MPRA SLYA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
122_E 132_K 2.886 1.00
79_Q 91_K 2.882 1.00
119_S 122_E 2.659 1.00
46_D 91_K 2.65 1.00
77_S 91_K 2.618 1.00
81_C 89_R 2.318 1.00
118_I 129_L 2.248 1.00
125_Q 129_L 2.135 1.00
48_S 87_A 2.024 1.00
125_Q 128_T 1.938 1.00
33_H 73_K 1.929 1.00
49_Q 67_L 1.926 1.00
41_H 100_I 1.91 1.00
71_E 78_R 1.828 1.00
117_G 136_N 1.813 1.00
81_C 87_A 1.785 1.00
80_T 88_K 1.753 1.00
48_S 51_Q 1.751 1.00
122_E 128_T 1.729 1.00
68_D 85_R 1.706 1.00
126_L 129_L 1.688 1.00
95_K 98_P 1.615 1.00
41_H 92_L 1.566 1.00
95_K 99_L 1.531 1.00
67_L 90_I 1.523 1.00
74_G 95_K 1.508 1.00
30_T 33_H 1.481 1.00
44_P 55_A 1.444 1.00
68_D 72_E 1.428 1.00
122_E 125_Q 1.419 1.00
129_L 132_K 1.414 1.00
41_H 97_E 1.329 0.99
8_D 131_A 1.329 0.99
27_L 106_V 1.319 0.99
49_Q 88_K 1.304 0.99
98_P 102_E 1.294 0.99
50_I 60_Q 1.279 0.99
46_D 89_R 1.267 0.99
49_Q 90_I 1.264 0.99
36_T 66_T 1.255 0.99
67_L 76_I 1.253 0.99
36_T 63_L 1.235 0.98
33_H 69_Q 1.23 0.98
122_E 129_L 1.213 0.98
58_I 62_S 1.198 0.98
128_T 132_K 1.177 0.98
59_E 65_R 1.176 0.98
12_L 130_I 1.17 0.97
99_L 102_E 1.163 0.97
64_V 68_D 1.153 0.97
78_R 88_K 1.148 0.97
49_Q 64_V 1.145 0.97
94_E 97_E 1.131 0.97
45_P 97_E 1.12 0.96
8_D 127_I 1.102 0.96
23_R 113_E 1.102 0.96
51_Q 54_K 1.097 0.96
92_L 96_A 1.095 0.96
73_K 95_K 1.081 0.95
21_D 31_Q 1.062 0.95
94_E 98_P 1.057 0.95
27_L 102_E 1.055 0.95
46_D 79_Q 1.048 0.94
75_L 99_L 1.047 0.94
28_E 73_K 1.043 0.94
59_E 62_S 1.041 0.94
12_L 134_E 1.041 0.94
32_T 66_T 1.034 0.94
23_R 106_V 1.029 0.94
13_V 17_R 1.015 0.93
10_A 13_V 1.011 0.93
68_D 71_E 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3deuA2199.90.191Contact Map0.654
4aikA2199.90.213Contact Map0.728
3cjnA10.979299.90.214Contact Map0.612
3e6mA80.965399.90.216Contact Map0.886
3zmdA40.993199.90.22Contact Map0.802
3k0lA20.993199.90.225Contact Map0.706
4em2A10.993199.90.226Contact Map0.575
2fa5A20.993199.90.228Contact Map0.758
3cdhA20.993199.90.228Contact Map0.681
3s2wA80.972299.90.228Contact Map0.841

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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