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OPENSEQ.org

URK - Uridine kinase
UniProt: P0A8F4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11701
Length: 213 (208)
Sequences: 2294
Seq/Len: 11.03

URK
Paralog alert: 0.67 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: URK YGGC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_A 88_S 5.234 1.00
96_S 103_M 4.379 1.00
49_Y 80_H 3.358 1.00
57_S 60_E 2.633 1.00
79_E 83_A 2.58 1.00
129_R 186_Y 2.542 1.00
76_L 80_H 2.479 1.00
52_D 55_H 2.429 1.00
12_G 132_L 2.308 1.00
89_A 108_T 2.131 1.00
142_L 177_L 2.125 1.00
14_A 123_L 2.03 1.00
73_D 102_R 1.975 1.00
166_A 170_K 1.932 1.00
91_D 108_T 1.931 1.00
82_Q 131_E 1.896 1.00
77_L 117_L 1.853 1.00
85_K 133_N 1.847 1.00
128_L 132_L 1.823 1.00
173_R 177_L 1.811 1.00
146_L 169_Q 1.805 1.00
53_Q 64_T 1.776 1.00
146_L 165_M 1.763 1.00
96_S 99_E 1.746 1.00
89_A 110_E 1.745 1.00
160_S 163_S 1.731 1.00
46_E 122_L 1.709 1.00
202_D 206_A 1.667 1.00
91_D 106_T 1.63 1.00
16_A 145_C 1.622 1.00
117_L 132_L 1.614 1.00
31_E 34_E 1.567 1.00
92_L 107_V 1.508 1.00
203_I 207_K 1.486 1.00
11_I 114_V 1.47 1.00
40_H 113_K 1.442 1.00
205_K 209_S 1.434 1.00
146_L 150_I 1.401 0.99
13_I 24_I 1.4 0.99
139_D 184_K 1.389 0.99
126_A 130_D 1.346 0.99
10_I 85_K 1.317 0.99
46_E 74_H 1.313 0.99
80_H 83_A 1.311 0.99
205_K 210_Q 1.304 0.99
184_K 190_I 1.261 0.99
123_L 135_S 1.245 0.98
63_K 70_S 1.235 0.98
202_D 207_K 1.217 0.98
136_I 204_L 1.213 0.98
83_A 86_R 1.208 0.98
78_L 82_Q 1.206 0.98
50_Y 72_M 1.204 0.98
58_M 62_V 1.201 0.98
17_S 176_F 1.199 0.98
15_G 20_G 1.198 0.98
15_G 19_S 1.193 0.98
147_M 151_K 1.187 0.98
54_S 101_T 1.185 0.98
53_Q 66_Y 1.173 0.98
144_I 147_M 1.155 0.97
10_I 132_L 1.146 0.97
151_K 155_N 1.134 0.97
57_S 61_R 1.134 0.97
154_V 164_V 1.133 0.97
82_Q 86_R 1.126 0.97
206_A 210_Q 1.121 0.97
146_L 173_R 1.116 0.96
167_Q 172_V 1.107 0.96
172_V 175_M 1.105 0.96
95_Y 100_H 1.104 0.96
207_K 210_Q 1.104 0.96
142_L 145_C 1.103 0.96
203_I 210_Q 1.097 0.96
24_I 138_V 1.09 0.96
48_C 92_L 1.09 0.96
135_S 188_D 1.088 0.96
89_A 111_P 1.088 0.96
52_D 101_T 1.078 0.95
9_V 134_F 1.069 0.95
97_Y 100_H 1.069 0.95
153_D 157_R 1.052 0.95
123_L 187_A 1.047 0.94
68_H 179_F 1.038 0.94
50_Y 67_D 1.038 0.94
99_E 103_M 1.028 0.94
145_C 176_F 1.028 0.94
33_R 116_I 1.026 0.94
53_Q 100_H 1.022 0.93
45_P 48_C 1.022 0.93
172_V 176_F 1.019 0.93
141_P 144_I 1.017 0.93
94_V 103_M 1.017 0.93
78_L 127_R 1.014 0.93
81_L 117_L 1.005 0.93
78_L 128_L 1.003 0.93
199_I 203_I 1.003 0.93
208_I 212_F 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jeoA10.97651000.431Contact Map0.767
2ga8A10.9391000.441Contact Map0.618
3tqcA20.94371000.452Contact Map0.777
1a7jA10.96241000.472Contact Map0.523
4bfzA20.94371000.504Contact Map0.791
3aszA20.96711000.506Contact Map0.785
1uj2A20.98121000.51Contact Map0.793
1rz3A10.845199.90.523Contact Map0.633
4gi7A80.93999.90.56Contact Map0.817
2qt1A10.901499.90.561Contact Map0.639

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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