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OPENSEQ.org
TALA - Transaldolase A
UniProt: P0A867 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11797
Length: 316 (316)
Sequences: 1156
Seq/Len: 3.66
TALA
Paralog alert: 0.34 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FSAA FSAB TALA TALB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
107_S 132_L 4.687 1.00
140_R 143_E 4.322 1.00
112_R 148_E 4.135 1.00
108_I 144_E 3.967 1.00
119_Q 125_K 3.581 1.00
105_E 109_E 3.256 1.00
182_Y 231_Q 3.153 1.00
83_E 86_K 2.591 1.00
234_A 261_K 2.576 1.00
277_E 281_R 2.529 1.00
134_S 157_L 2.424 1.00
233_L 258_V 2.391 1.00
36_S 304_D 2.321 1.00
21_E 24_R 2.273 1.00
284_H 291_V 2.168 1.00
102_F 137_E 2.088 1.00
26_Y 249_K 2.087 1.00
104_K 144_E 2.082 1.00
119_Q 124_E 2.051 1.00
249_K 253_E 2.043 1.00
48_E 315_K 2.04 1.00
160_F 164_R 2.034 1.00
112_R 150_I 1.958 1.00
136_W 165_A 1.933 1.00
276_S 279_E 1.909 1.00
151_N 172_F 1.903 1.00
112_R 144_E 1.82 0.99
99_R 309_E 1.773 0.99
143_E 147_K 1.773 0.99
110_K 113_H 1.74 0.99
310_D 314_A 1.714 0.99
116_D 119_Q 1.7 0.99
144_E 148_E 1.696 0.99
132_L 145_L 1.671 0.99
103_D 106_K 1.647 0.99
195_V 198_E 1.644 0.99
64_T 67_Q 1.633 0.99
162_Q 294_L 1.631 0.99
220_I 240_R 1.602 0.98
67_Q 71_A 1.594 0.98
291_V 295_S 1.582 0.98
295_S 299_R 1.572 0.98
188_R 191_M 1.545 0.98
296_E 300_L 1.538 0.98
142_A 154_L 1.529 0.97
75_K 79_N 1.514 0.97
113_H 116_D 1.513 0.97
108_I 112_R 1.503 0.97
219_T 223_G 1.503 0.97
3_E 256_S 1.477 0.97
190_P 194_Y 1.471 0.97
164_R 214_Q 1.457 0.96
116_D 120_Q 1.434 0.96
104_K 140_R 1.431 0.96
312_L 315_K 1.426 0.96
57_W 61_N 1.423 0.96
3_E 254_K 1.421 0.96
3_E 6_G 1.409 0.95
71_A 113_H 1.405 0.95
164_R 211_Y 1.392 0.95
288_A 292_E 1.391 0.95
184_W 292_E 1.379 0.95
192_D 195_V 1.367 0.94
306_R 310_D 1.345 0.94
60_K 63_K 1.339 0.93
192_D 198_E 1.334 0.93
4_L 13_V 1.334 0.93
190_P 197_E 1.328 0.93
115_V 128_I 1.328 0.93
94_T 118_Y 1.328 0.93
22_S 25_H 1.316 0.93
58_G 72_A 1.316 0.93
82_A 121_Q 1.314 0.93
282_W 302_A 1.308 0.92
279_E 283_E 1.301 0.92
233_L 254_K 1.296 0.92
211_Y 214_Q 1.288 0.92
82_A 86_K 1.279 0.91
52_D 315_K 1.271 0.91
196_V 230_E 1.27 0.91
3_E 233_L 1.267 0.91
260_R 263_I 1.267 0.91
303_V 306_R 1.266 0.91
260_R 265_P 1.264 0.91
260_R 264_P 1.26 0.90
299_R 303_V 1.26 0.90
300_L 303_V 1.252 0.90
303_V 307_K 1.246 0.90
121_Q 206_R 1.236 0.89
100_L 106_K 1.229 0.89
209_Y 265_P 1.217 0.88
23_I 76_L 1.215 0.88
197_E 206_R 1.206 0.88
137_E 281_R 1.203 0.87
206_R 210_D 1.202 0.87
181_I 204_S 1.194 0.87
40_K 246_N 1.187 0.86
264_P 267_Q 1.187 0.86
40_K 300_L 1.182 0.86
228_R 232_I 1.18 0.86
153_N 177_F 1.174 0.86
153_N 156_L 1.166 0.85
197_E 234_A 1.164 0.85
285_N 288_A 1.161 0.85
77_A 83_E 1.147 0.84
153_N 175_S 1.144 0.84
2_N 5_D 1.143 0.84
160_F 207_N 1.141 0.83
310_D 313_A 1.137 0.83
65_Q 313_A 1.131 0.83
2_N 252_Q 1.129 0.83
157_L 212_Y 1.128 0.82
233_L 256_S 1.127 0.82
275_M 279_E 1.126 0.82
49_H 53_D 1.125 0.82
134_S 154_L 1.124 0.82
146_E 151_N 1.122 0.82
33_T 69_V 1.111 0.81
154_L 171_V 1.111 0.81
176_P 208_I 1.094 0.80
102_F 281_R 1.094 0.80
105_E 108_I 1.091 0.79
95_E 177_F 1.088 0.79
74_D 110_K 1.077 0.78
266_S 269_F 1.074 0.78
8_K 29_Q 1.063 0.77
281_R 285_N 1.062 0.77
220_I 223_G 1.06 0.77
242_T 301_F 1.056 0.76
131_K 242_T 1.045 0.75
177_F 297_G 1.029 0.74
129_L 165_A 1.029 0.74
288_A 295_S 1.023 0.73
36_S 40_K 1.023 0.73
140_R 298_I 1.022 0.73
137_E 248_L 1.022 0.73
191_M 195_V 1.014 0.72
166_C 223_G 1.012 0.72
277_E 285_N 1.01 0.72
156_L 177_F 1.004 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cwnA20.99681000.086Contact Map0.712
3tkfA20.99681000.091Contact Map0.714
3m16A10.99681000.091Contact Map0.67
3hjzA10.99681000.092Contact Map0.667
3cq0A20.99371000.093Contact Map0.693
2e1dA20.99681000.1Contact Map0.69
3r5eA10.9621000.188Contact Map0.552
3clmA10.94621000.2Contact Map0.492
1wx0A100.68041000.41Contact Map0.679
3s1xA50.68351000.42Contact Map0.644
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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