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OPENSEQ.org

LEXA - LexA repressor
UniProt: P0A7C2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10533
Length: 202 (197)
Sequences: 2510
Seq/Len: 12.74

LEXA
Paralog alert: 0.41 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: COHE LEXA UMUD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
157_R 170_E 4.09 1.00
19_I 47_L 3.59 1.00
118_M 174_F 3.256 1.00
82_V 146_V 3.007 1.00
84_A 115_V 2.967 1.00
131_L 155_V 2.659 1.00
164_K 178_V 2.534 1.00
18_H 22_T 2.511 1.00
126_M 129_D 2.327 1.00
122_D 172_S 2.266 1.00
11_V 15_I 2.143 1.00
161_Q 166_E 1.943 1.00
143_Q 191_L 1.917 1.00
9_Q 13_D 1.901 1.00
112_L 130_L 1.879 1.00
76_L 112_L 1.878 1.00
112_L 132_A 1.866 1.00
159_K 168_L 1.832 1.00
159_K 166_E 1.795 1.00
133_V 192_A 1.786 1.00
29_A 40_P 1.698 1.00
139_V 145_V 1.682 1.00
155_V 192_A 1.671 1.00
124_G 170_E 1.668 1.00
118_M 173_E 1.654 1.00
81_R 116_S 1.643 1.00
154_T 169_P 1.638 1.00
168_L 176_P 1.635 1.00
125_I 144_V 1.62 1.00
109_A 135_K 1.583 1.00
114_R 130_L 1.558 1.00
133_V 146_V 1.531 1.00
129_D 197_R 1.524 1.00
150_D 185_S 1.499 1.00
29_A 33_Q 1.496 1.00
31_I 43_A 1.488 1.00
83_A 87_P 1.452 1.00
37_F 43_A 1.437 1.00
63_S 68_L 1.406 0.99
35_L 65_G 1.395 0.99
115_V 131_L 1.393 0.99
37_F 42_A 1.386 0.99
18_H 21_Q 1.386 0.99
123_I 170_E 1.381 0.99
85_G 156_K 1.362 0.99
32_A 40_P 1.34 0.99
32_A 35_L 1.328 0.99
85_G 117_G 1.323 0.99
115_V 155_V 1.319 0.99
28_R 40_P 1.316 0.99
12_F 47_L 1.313 0.99
119_S 156_K 1.307 0.99
17_D 21_Q 1.285 0.99
12_F 19_I 1.283 0.99
144_V 157_R 1.261 0.99
145_V 158_L 1.251 0.99
30_E 34_R 1.243 0.98
82_V 113_L 1.233 0.98
148_R 187_T 1.232 0.98
42_A 45_E 1.222 0.98
13_D 17_D 1.221 0.98
147_A 158_L 1.214 0.98
43_A 46_H 1.2 0.98
56_I 66_I 1.197 0.98
146_V 155_V 1.19 0.98
5_T 8_Q 1.187 0.98
148_R 189_E 1.186 0.98
98_Y 112_L 1.183 0.98
41_N 44_E 1.18 0.98
14_L 18_H 1.179 0.98
133_V 155_V 1.176 0.98
51_A 58_I 1.175 0.98
28_R 47_L 1.173 0.98
75_G 99_Q 1.164 0.97
115_V 125_I 1.164 0.97
164_K 180_D 1.163 0.97
76_L 110_D 1.155 0.97
45_E 50_L 1.154 0.97
82_V 155_V 1.122 0.97
78_L 96_G 1.118 0.96
40_P 44_E 1.084 0.96
117_G 127_D 1.082 0.96
57_E 67_R 1.082 0.96
125_I 195_V 1.078 0.95
16_R 47_L 1.068 0.95
111_F 135_K 1.064 0.95
44_E 48_K 1.056 0.95
147_A 167_L 1.056 0.95
78_L 98_Y 1.054 0.95
131_L 192_A 1.047 0.94
122_D 170_E 1.044 0.94
28_R 44_E 1.024 0.93
157_R 168_L 1.019 0.93
167_L 177_I 1.018 0.93
166_E 176_P 1.009 0.93
113_L 153_V 1.006 0.93
87_P 154_T 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jhfA211000.22Contact Map0.671
3bdnA20.95051000.266Contact Map0.635
3k2zA20.96531000.295Contact Map0.71
2fjrA20.84161000.411Contact Map0.533
1umuA20.564499.90.512Contact Map0.793
2hnfA10.589199.90.514Contact Map0.713
1kcaA80.599.80.566Contact Map0.885
2bnmA20.856499.70.62Contact Map0.348
1dw9A100.688199.40.686Contact Map0.412
4me8A10.440698.80.754Contact Map0.669

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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