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OPENSEQ.org

UMUD - Protein UmuD
UniProt: P0AG11 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11057
Length: 139 (128)
Sequences: 2553
Seq/Len: 19.95

UMUD
Paralog alert: 0.49 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: COHE LEXA UMUD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
98_K 110_M 4.586 1.00
72_L 96_V 2.842 1.00
59_D 114_Y 2.817 1.00
104_T 118_T 2.756 1.00
63_D 112_S 2.722 1.00
22_V 87_I 2.616 1.00
24_C 56_A 2.581 1.00
100_Q 108_I 2.522 1.00
95_T 109_P 2.355 1.00
70_D 136_K 2.264 1.00
15_F 53_F 2.127 1.00
100_Q 106_Q 2.121 1.00
64_G 110_M 2.088 1.00
80_A 86_V 1.969 1.00
67_S 70_D 1.95 1.00
53_F 71_L 1.949 1.00
50_A 76_S 1.815 1.00
56_A 72_L 1.778 1.00
84_D 130_V 1.746 1.00
59_D 113_A 1.738 1.00
66_I 85_I 1.733 1.00
55_K 71_L 1.73 1.00
60_S 97_K 1.695 1.00
21_L 57_S 1.687 1.00
74_V 131_V 1.665 1.00
96_V 131_V 1.665 1.00
134_V 138_M 1.66 1.00
108_I 116_P 1.591 1.00
67_S 136_K 1.575 1.00
64_G 98_K 1.549 1.00
63_D 110_M 1.529 1.00
53_F 73_I 1.494 1.00
89_A 126_D 1.492 1.00
91_D 124_T 1.484 1.00
38_I 53_F 1.461 1.00
85_I 98_K 1.4 0.99
14_T 39_D 1.4 0.99
74_V 87_I 1.384 0.99
56_A 96_V 1.362 0.99
86_V 99_L 1.357 0.99
91_D 123_D 1.292 0.99
109_P 116_P 1.243 0.98
17_L 36_Q 1.216 0.98
15_F 51_T 1.204 0.98
54_V 87_I 1.198 0.98
119_I 125_L 1.18 0.98
89_A 128_F 1.171 0.98
57_S 68_D 1.165 0.97
22_V 54_V 1.164 0.97
52_Y 76_S 1.161 0.97
82_H 100_Q 1.157 0.97
88_A 99_L 1.147 0.97
17_L 38_I 1.135 0.97
58_G 68_D 1.134 0.97
106_Q 118_T 1.129 0.97
64_G 85_I 1.128 0.97
74_V 96_V 1.124 0.97
14_T 37_R 1.099 0.96
25_G 58_G 1.08 0.95
65_G 110_M 1.067 0.95
104_T 120_S 1.059 0.95
106_Q 116_P 1.05 0.94
58_G 97_K 1.044 0.94
56_A 66_I 1.037 0.94
101_L 105_V 1.032 0.94
72_L 131_V 1.031 0.94
23_Q 27_P 1.012 0.93
81_S 84_D 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jhfA20.978499.90.237Contact Map0.739
1umuA20.820199.90.248Contact Map0.786
3k2zA20.971299.90.253Contact Map0.769
2hnfA10.863399.90.268Contact Map0.727
3bdnA20.942499.90.287Contact Map0.732
1kcaA80.70599.80.38Contact Map0.843
2fjrA20.841799.70.445Contact Map0.386
4me8A10.611598.80.649Contact Map0.712
4k8wA10.589998.70.661Contact Map0.356
1b12A40.669197.80.733Contact Map0.591

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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