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OPENSEQ.org
PYRB - Aspartate carbamoyltransferase catalytic chain
UniProt: P0A786 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10805
Length: 311 (301)
Sequences: 3664
Seq/Len: 12.17
PYRB
Paralog alert: 0.85 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: OTC1 OTC2 PYRB YGEW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
157_H 184_R 4.224 1.00
252_A 277_D 4.14 1.00
264_V 274_I 3.353 1.00
38_E 41_K 3.132 1.00
157_H 186_Y 3.036 1.00
159_A 223_V 2.928 1.00
146_I 225_I 2.773 1.00
217_E 257_N 2.77 1.00
98_T 288_Q 2.733 1.00
215_S 218_E 2.724 1.00
224_D 259_K 2.634 1.00
263_K 285_W 2.61 1.00
26_A 147_Q 2.607 1.00
27_T 302_A 2.563 1.00
97_S 121_G 2.495 1.00
265_L 285_W 2.45 1.00
149_T 285_W 2.444 1.00
32_K 148_E 2.415 1.00
29_A 147_Q 2.335 1.00
12_S 134_Q 2.332 1.00
45_I 64_M 2.331 1.00
46_A 100_V 2.303 1.00
64_M 69_A 2.255 1.00
188_I 219_V 2.094 1.00
197_Q 201_D 2.077 1.00
191_D 214_S 2.037 1.00
252_A 256_H 1.979 1.00
22_N 147_Q 1.924 1.00
102_A 301_L 1.911 1.00
177_L 185_F 1.87 1.00
139_T 176_A 1.867 1.00
184_R 211_S 1.864 1.00
29_A 144_F 1.856 1.00
143_L 176_A 1.838 1.00
226_L 250_L 1.82 1.00
253_S 256_H 1.818 1.00
262_M 283_H 1.81 1.00
150_Q 156_L 1.78 1.00
220_M 226_L 1.726 1.00
66_R 298_Q 1.711 1.00
213_H 218_E 1.706 1.00
18_R 22_N 1.696 1.00
17_S 20_D 1.681 1.00
104_V 128_A 1.654 1.00
150_Q 261_N 1.638 1.00
24_V 303_L 1.633 1.00
137_T 297_R 1.633 1.00
255_L 262_M 1.615 1.00
232_Q 235_R 1.609 1.00
18_R 154_D 1.609 1.00
98_T 291_G 1.609 1.00
31_L 302_A 1.595 1.00
149_T 288_Q 1.583 1.00
173_L 227_Y 1.582 1.00
65_H 70_S 1.581 1.00
217_E 254_D 1.56 1.00
159_A 188_I 1.556 1.00
58_L 96_I 1.533 1.00
184_R 209_A 1.509 1.00
193_L 244_V 1.494 1.00
10_I 300_L 1.491 1.00
186_Y 213_H 1.476 1.00
191_D 194_A 1.458 1.00
225_I 263_K 1.457 1.00
137_T 300_L 1.451 1.00
222_E 259_K 1.442 1.00
258_A 262_M 1.442 1.00
194_A 214_S 1.428 1.00
8_K 20_D 1.425 1.00
18_R 179_K 1.418 1.00
54_T 92_T 1.409 1.00
228_M 250_L 1.406 0.99
23_L 303_L 1.398 0.99
227_Y 289_Q 1.392 0.99
279_D 286_Y 1.366 0.99
201_D 204_D 1.346 0.99
281_T 284_A 1.345 0.99
27_T 303_L 1.344 0.99
94_S 280_K 1.343 0.99
25_L 144_F 1.332 0.99
102_A 305_L 1.328 0.99
161_V 220_M 1.32 0.99
63_S 301_L 1.314 0.99
57_R 61_E 1.313 0.99
54_T 86_G 1.299 0.99
255_L 264_V 1.296 0.99
152_R 156_L 1.294 0.99
75_S 79_N 1.292 0.99
189_A 194_A 1.29 0.99
159_A 186_Y 1.28 0.99
255_L 283_H 1.267 0.99
250_L 264_V 1.257 0.99
90_A 114_R 1.255 0.99
25_L 296_A 1.255 0.99
29_A 148_E 1.25 0.99
45_I 104_V 1.241 0.98
218_E 221_A 1.233 0.98
134_Q 175_Q 1.231 0.98
25_L 147_Q 1.23 0.98
54_T 81_S 1.222 0.98
249_V 275_A 1.214 0.98
90_A 119_F 1.188 0.98
143_L 180_F 1.181 0.98
10_I 140_L 1.178 0.98
140_L 300_L 1.173 0.98
25_L 29_A 1.172 0.98
103_I 123_V 1.171 0.98
221_A 257_N 1.166 0.97
200_L 212_L 1.165 0.97
239_S 243_N 1.157 0.97
12_S 175_Q 1.157 0.97
10_I 16_L 1.145 0.97
27_T 30_K 1.131 0.97
148_E 292_N 1.126 0.97
240_E 243_N 1.124 0.97
251_R 275_A 1.115 0.96
236_L 241_Y 1.098 0.96
32_K 292_N 1.097 0.96
252_A 281_T 1.093 0.96
12_S 15_D 1.087 0.96
216_I 254_D 1.082 0.96
9_H 120_S 1.081 0.95
144_F 296_A 1.078 0.95
45_I 102_A 1.076 0.95
214_S 248_F 1.069 0.95
22_N 26_A 1.069 0.95
295_F 298_Q 1.068 0.95
156_L 225_I 1.066 0.95
39_L 302_A 1.065 0.95
13_I 176_A 1.06 0.95
150_Q 224_D 1.057 0.95
22_N 180_F 1.048 0.94
186_Y 211_S 1.048 0.94
94_S 287_F 1.048 0.94
146_I 156_L 1.044 0.94
213_H 219_V 1.036 0.94
114_R 118_E 1.035 0.94
64_M 71_V 1.032 0.94
291_G 295_F 1.03 0.94
28_A 144_F 1.029 0.94
150_Q 285_W 1.029 0.94
120_S 123_V 1.028 0.94
140_L 296_A 1.028 0.94
157_H 222_E 1.028 0.94
16_L 24_V 1.025 0.93
14_N 175_Q 1.019 0.93
38_E 68_G 1.019 0.93
95_V 290_A 1.014 0.93
255_L 274_I 1.01 0.93
113_A 116_A 1.01 0.93
150_Q 263_K 1.005 0.93
66_R 294_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3csuA30.9904100-0.004Contact Map0.791
1ml4A10.9711100-0.001Contact Map0.732
4iv5A60.97111000.009Contact Map0.805
1pg5A10.94861000.017Contact Map0.767
4eknB10.96461000.02Contact Map0.742
4ep1A20.97751000.027Contact Map0.764
3gd5A60.97431000.027Contact Map0.792
1pvvA10.97431000.028Contact Map0.781
4nf2A30.97751000.028Contact Map0.815
2i6uA30.9551000.033Contact Map0.775
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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