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OPENSEQ.org
OTC1 - Ornithine carbamoyltransferase chain I
UniProt: P04391 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10069
Length: 334 (314)
Sequences: 3606
Seq/Len: 11.48
OTC1
Paralog alert: 0.84 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: OTC1 OTC2 PYRB YGEW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
158_T 183_D 4.214 1.00
258_S 304_E 4.177 1.00
271_F 301_V 3.385 1.00
41_A 44_T 3.06 1.00
160_V 226_A 3.049 1.00
158_T 185_R 3.048 1.00
220_A 263_L 2.809 1.00
99_R 315_D 2.799 1.00
145_M 228_F 2.795 1.00
218_D 221_K 2.754 1.00
25_Q 146_Q 2.688 1.00
270_K 312_I 2.649 1.00
227_D 266_N 2.539 1.00
31_K 147_E 2.53 1.00
98_G 122_S 2.52 1.00
26_L 329_V 2.507 1.00
272_L 312_I 2.456 1.00
148_H 312_I 2.447 1.00
48_I 67_A 2.372 1.00
49_A 101_Y 2.353 1.00
91_K 116_T 2.345 1.00
28_A 146_Q 2.344 1.00
11_K 133_F 2.335 1.00
196_A 200_T 2.298 1.00
67_A 72_A 2.257 1.00
190_Q 217_E 2.153 1.00
187_V 222_G 2.116 1.00
258_S 262_Q 2.047 1.00
259_K 262_Q 2.024 1.00
21_N 146_Q 2.016 1.00
28_A 143_L 1.96 1.00
183_D 214_T 1.91 1.00
229_I 256_V 1.903 1.00
103_G 328_M 1.886 1.00
177_A 184_L 1.882 1.00
138_L 176_A 1.872 1.00
183_D 212_N 1.823 1.00
142_L 176_A 1.82 1.00
269_V 310_A 1.799 1.00
223_V 229_I 1.781 1.00
16_T 19_E 1.773 1.00
216_T 221_K 1.731 1.00
69_D 325_K 1.727 1.00
105_Q 128_G 1.669 1.00
200_T 203_R 1.665 1.00
192_C 250_L 1.662 1.00
68_Y 73_R 1.658 1.00
99_R 318_E 1.643 1.00
173_M 230_Y 1.637 1.00
53_E 113_I 1.621 1.00
110_G 113_I 1.615 1.00
17_P 21_N 1.613 1.00
23_L 330_A 1.609 1.00
148_H 315_D 1.607 1.00
61_C 97_L 1.604 1.00
220_A 260_M 1.602 1.00
30_L 329_V 1.594 1.00
136_T 324_I 1.591 1.00
17_P 155_N 1.581 1.00
204_A 207_Q 1.579 1.00
160_V 187_V 1.554 1.00
261_M 269_V 1.536 1.00
9_F 327_V 1.518 1.00
193_W 217_E 1.505 1.00
228_F 270_K 1.463 1.00
185_R 216_T 1.445 1.00
17_P 179_L 1.441 1.00
188_A 193_W 1.434 1.00
57_T 93_T 1.433 1.00
230_Y 316_Q 1.427 1.00
264_T 269_V 1.425 1.00
149_L 157_M 1.413 1.00
7_K 19_E 1.41 1.00
190_Q 193_W 1.382 0.99
136_T 327_V 1.382 0.99
162_A 223_V 1.373 0.99
66_A 328_M 1.357 0.99
231_T 256_V 1.354 0.99
57_T 87_K 1.353 0.99
256_V 271_F 1.344 0.99
224_E 263_L 1.34 0.99
306_F 313_V 1.339 0.99
95_R 307_E 1.336 0.99
261_M 271_F 1.33 0.99
24_L 143_L 1.319 0.99
308_S 311_S 1.318 0.99
32_A 36_S 1.312 0.99
255_Q 302_T 1.305 0.99
261_M 310_A 1.299 0.99
199_V 215_L 1.287 0.99
24_L 146_Q 1.282 0.99
103_G 332_L 1.278 0.99
48_I 105_Q 1.278 0.99
78_G 81_G 1.276 0.99
91_K 120_Y 1.271 0.99
225_G 266_N 1.266 0.99
60_R 64_E 1.258 0.99
149_L 268_E 1.256 0.99
94_A 117_L 1.256 0.99
296_H 299_M 1.255 0.99
160_V 185_R 1.249 0.99
245_A 249_A 1.248 0.99
9_F 139_L 1.245 0.98
57_T 83_Q 1.244 0.98
9_F 15_F 1.236 0.98
28_A 147_E 1.219 0.98
221_K 224_E 1.213 0.98
133_F 175_E 1.204 0.98
200_T 204_A 1.197 0.98
240_A 243_K 1.189 0.98
142_L 180_T 1.184 0.98
24_L 28_A 1.172 0.98
139_L 327_V 1.156 0.97
205_L 209_N 1.156 0.97
11_K 14_D 1.155 0.97
26_L 29_K 1.154 0.97
104_I 117_L 1.151 0.97
104_I 123_V 1.15 0.97
322_H 325_K 1.145 0.97
157_M 228_F 1.14 0.97
217_E 254_Y 1.137 0.97
31_K 319_N 1.13 0.97
258_S 308_S 1.129 0.97
21_N 25_Q 1.129 0.97
201_E 204_A 1.128 0.97
153_A 157_M 1.125 0.97
115_E 119_E 1.123 0.97
147_E 319_N 1.122 0.97
158_T 225_G 1.119 0.96
216_T 222_G 1.108 0.96
48_I 103_G 1.108 0.96
13_L 201_E 1.105 0.96
219_V 260_M 1.105 0.96
12_L 176_A 1.103 0.96
11_K 175_E 1.102 0.96
112_E 116_T 1.098 0.96
143_L 323_T 1.097 0.96
185_R 214_T 1.096 0.96
95_R 314_F 1.091 0.96
261_M 301_V 1.08 0.95
145_M 157_M 1.079 0.95
67_A 74_V 1.075 0.95
8_H 118_A 1.074 0.95
257_N 302_T 1.074 0.95
29_K 33_D 1.072 0.95
83_Q 86_H 1.068 0.95
8_H 121_A 1.066 0.95
27_A 143_L 1.06 0.95
108_G 130_T 1.06 0.95
246_E 250_L 1.053 0.95
26_L 330_A 1.053 0.95
220_A 259_K 1.047 0.94
256_V 301_V 1.043 0.94
139_L 323_T 1.03 0.94
21_N 180_T 1.028 0.94
15_F 23_L 1.022 0.93
315_D 318_E 1.019 0.93
138_L 169_M 1.016 0.93
13_L 175_E 1.013 0.93
53_E 84_I 1.013 0.93
64_E 76_Y 1.011 0.93
34_K 69_D 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4amuA40.9911000.023Contact Map0.778
1duvG30.9881000.025Contact Map0.797
4h31A30.9881000.028Contact Map0.78
2w37A30.9851000.03Contact Map0.807
1dxhA10.9911000.034Contact Map0.766
1pvvA10.93111000.059Contact Map0.79
1vlvA10.93111000.061Contact Map0.705
4ep1A20.91621000.069Contact Map0.763
4nf2A30.91621000.07Contact Map0.826
2i6uA30.91621000.07Contact Map0.8
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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