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OPENSEQ.org
DACC - D-alanyl-D-alanine carboxypeptidase DacC
UniProt: P08506 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10203
Length: 400 (363)
Sequences: 1576
Seq/Len: 4.34
DACC
Paralog alert: 0.49 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DACA DACC DACD PBP7
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_D 185_R 4.175 1.00
121_V 140_L 3.369 1.00
44_L 281_G 3.263 1.00
55_E 58_A 2.999 1.00
257_L 281_G 2.935 1.00
94_G 142_D 2.886 1.00
76_V 140_L 2.862 1.00
191_G 234_M 2.781 1.00
127_G 133_G 2.629 1.00
120_S 123_D 2.627 1.00
232_D 256_R 2.572 1.00
59_D 166_N 2.519 1.00
90_M 118_Q 2.516 1.00
353_T 365_Q 2.506 1.00
148_Q 172_V 2.486 1.00
251_T 254_D 2.449 1.00
57_N 60_E 2.434 1.00
164_L 190_L 2.417 1.00
128_V 137_C 2.406 1.00
128_V 140_L 2.406 1.00
61_K 181_F 2.4 1.00
126_K 207_E 2.382 1.00
145_A 154_L 2.372 1.00
74_Y 193_A 2.263 1.00
307_K 372_E 2.249 1.00
89_D 143_Y 2.208 1.00
341_L 351_V 2.131 1.00
345_L 370_V 2.099 1.00
162_L 193_A 2.083 1.00
147_S 150_S 2.081 1.00
90_M 120_S 2.074 1.00
191_G 247_V 2.022 1.00
346_K 373_N 2.02 1.00
158_Y 161_K 2.002 1.00
44_L 257_L 1.98 1.00
313_G 371_M 1.961 1.00
95_K 115_P 1.948 1.00
70_I 247_V 1.945 1.00
78_Q 158_Y 1.934 1.00
289_T 292_K 1.917 1.00
230_N 252_Q 1.915 1.00
88_T 122_A 1.911 1.00
145_A 150_S 1.842 1.00
47_Y 258_I 1.819 1.00
350_V 367_P 1.806 1.00
259_S 274_S 1.791 1.00
232_D 249_S 1.79 1.00
42_W 54_A 1.782 1.00
250_A 282_F 1.765 1.00
71_M 167_T 1.744 0.99
41_A 184_A 1.738 0.99
185_R 189_L 1.733 0.99
150_S 153_G 1.728 0.99
96_D 142_D 1.701 0.99
248_A 274_S 1.691 0.99
273_E 276_K 1.636 0.99
71_M 159_A 1.636 0.99
73_S 128_V 1.633 0.99
299_T 309_E 1.625 0.99
76_V 128_V 1.622 0.99
187_M 247_V 1.62 0.99
168_T 181_F 1.592 0.99
91_V 139_A 1.591 0.99
94_G 97_A 1.582 0.99
92_T 118_Q 1.579 0.99
184_A 262_L 1.575 0.99
351_V 370_V 1.573 0.99
192_K 258_I 1.569 0.99
91_V 143_Y 1.565 0.99
350_V 353_T 1.558 0.99
153_G 157_G 1.518 0.98
355_D 365_Q 1.515 0.98
41_A 62_L 1.513 0.98
67_L 187_M 1.508 0.98
362_S 365_Q 1.504 0.98
46_D 255_M 1.495 0.98
93_V 139_A 1.489 0.98
357_Q 362_S 1.489 0.98
208_K 225_W 1.46 0.97
61_K 166_N 1.457 0.97
72_T 137_C 1.443 0.97
67_L 247_V 1.443 0.97
176_D 241_G 1.441 0.97
239_T 242_A 1.439 0.97
349_Q 370_V 1.435 0.97
167_T 182_S 1.427 0.97
242_A 245_N 1.426 0.97
126_K 130_I 1.413 0.97
334_Y 368_L 1.396 0.96
202_Y 249_S 1.381 0.96
64_P 182_S 1.38 0.96
195_I 202_Y 1.379 0.96
164_L 189_L 1.377 0.96
346_K 349_Q 1.357 0.96
127_G 136_A 1.356 0.96
347_K 373_N 1.337 0.95
74_Y 158_Y 1.335 0.95
122_A 126_K 1.333 0.95
86_K 89_D 1.323 0.95
70_I 194_L 1.321 0.95
87_L 122_A 1.319 0.95
170_Q 179_G 1.317 0.95
132_S 236_T 1.311 0.94
73_S 125_N 1.303 0.94
70_I 234_M 1.299 0.94
43_I 58_A 1.298 0.94
249_S 256_R 1.297 0.94
293_P 317_A 1.285 0.94
85_I 143_Y 1.284 0.94
157_G 161_K 1.282 0.94
333_S 357_Q 1.281 0.93
73_S 129_I 1.278 0.93
355_D 362_S 1.278 0.93
132_S 235_K 1.273 0.93
43_I 185_R 1.272 0.93
231_V 248_A 1.272 0.93
74_Y 197_D 1.27 0.93
193_A 197_D 1.265 0.93
95_K 99_A 1.263 0.93
87_L 125_N 1.262 0.93
42_W 56_G 1.257 0.93
67_L 262_L 1.256 0.93
76_V 85_I 1.256 0.93
81_K 200_E 1.255 0.93
137_C 172_V 1.245 0.92
200_E 203_A 1.243 0.92
63_D 176_D 1.237 0.92
68_T 180_Q 1.234 0.92
80_L 201_E 1.23 0.92
357_Q 360_G 1.225 0.91
79_A 84_K 1.215 0.91
61_K 183_T 1.212 0.91
310_V 370_V 1.21 0.91
102_N 105_L 1.2 0.90
318_G 364_E 1.195 0.90
227_S 230_N 1.189 0.90
103_P 107_G 1.184 0.89
289_T 319_S 1.179 0.89
111_M 127_G 1.171 0.89
75_V 79_A 1.165 0.88
65_A 242_A 1.163 0.88
93_V 113_L 1.161 0.88
63_D 241_G 1.159 0.88
130_I 207_E 1.15 0.87
41_A 57_N 1.149 0.87
291_I 314_A 1.148 0.87
70_I 191_G 1.147 0.87
302_V 343_A 1.145 0.87
41_A 262_L 1.144 0.87
306_D 375_E 1.142 0.87
76_V 121_V 1.133 0.86
376_E 382_R 1.118 0.85
311_N 371_M 1.115 0.85
203_A 206_K 1.115 0.85
305_G 343_A 1.111 0.85
370_V 373_N 1.108 0.85
377_G 381_G 1.098 0.84
122_A 204_I 1.098 0.84
170_Q 177_A 1.091 0.83
326_Q 329_N 1.09 0.83
310_V 374_V 1.089 0.83
133_G 136_A 1.088 0.83
162_L 190_L 1.086 0.83
246_L 274_S 1.068 0.82
158_Y 193_A 1.066 0.81
280_W 285_F 1.062 0.81
305_G 344_P 1.058 0.81
384_W 388_M 1.05 0.80
335_T 355_D 1.038 0.79
165_T 185_R 1.031 0.78
378_G 381_G 1.027 0.78
102_N 107_G 1.026 0.78
248_A 278_L 1.026 0.78
302_V 305_G 1.025 0.78
331_K 357_Q 1.016 0.77
248_A 259_S 1.015 0.77
292_K 317_A 1.012 0.77
80_L 85_I 1.006 0.76
44_L 259_S 1.005 0.76
300_Q 312_L 1.003 0.76
45_M 189_L 1.002 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3mzfA10.89751000.282Contact Map0.838
4k91A20.8651000.285Contact Map0.858
3itaA40.87751000.293Contact Map0.84
3a3jA10.85751000.306Contact Map0.838
1xp4A40.86251000.312Contact Map0.843
3mfdA20.8151000.33Contact Map0.819
3hunA20.9351000.41Contact Map0.849
1tvfA20.841000.424Contact Map0.856
2bcfA10.66751000.518Contact Map0.76
1es5A10.6151000.531Contact Map0.824
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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