| UniProt: | P00935 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10582 | ||
| Length: | 386 (380) | ||
| Sequences: | 5092 | ||
| Seq/Len: | 13.40 |
| METB
Paralog alert: 0.82 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: METB METC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 183_N | 186_A | 3.986 | 1.00 | |
| 267_Q | 282_E | 3.602 | 1.00 | |
| 131_R | 165_E | 3.55 | 1.00 | |
| 6_A | 368_D | 3.479 | 1.00 | |
| 93_L | 120_L | 3.171 | 1.00 | |
| 260_Q | 264_K | 3.081 | 1.00 | |
| 377_E | 381_R | 2.917 | 1.00 | |
| 67_G | 212_I | 2.88 | 1.00 | |
| 93_L | 135_A | 2.813 | 1.00 | |
| 157_A | 161_H | 2.689 | 1.00 | |
| 321_F | 332_S | 2.639 | 1.00 | |
| 61_L | 210_V | 2.597 | 1.00 | |
| 66_G | 186_A | 2.58 | 1.00 | |
| 273_K | 305_D | 2.519 | 1.00 | |
| 157_A | 291_R | 2.487 | 1.00 | |
| 274_K | 303_E | 2.463 | 1.00 | |
| 140_L | 171_V | 2.421 | 1.00 | |
| 55_D | 59_R | 2.305 | 1.00 | |
| 286_H | 290_A | 2.206 | 1.00 | |
| 265_Y | 377_E | 2.162 | 1.00 | |
| 160_C | 170_S | 2.156 | 1.00 | |
| 8_I | 63_E | 2.156 | 1.00 | |
| 347_P | 351_A | 2.156 | 1.00 | |
| 92_D | 139_K | 2.085 | 1.00 | |
| 118_R | 135_A | 2.072 | 1.00 | |
| 127_E | 158_K | 2.068 | 1.00 | |
| 303_E | 358_T | 2.061 | 1.00 | |
| 253_E | 257_R | 2.038 | 1.00 | |
| 164_R | 190_D | 1.973 | 1.00 | |
| 181_L | 256_Q | 1.952 | 1.00 | |
| 262_I | 373_I | 1.93 | 1.00 | |
| 126_D | 129_A | 1.923 | 1.00 | |
| 161_H | 165_E | 1.914 | 1.00 | |
| 154_V | 159_I | 1.883 | 1.00 | |
| 350_R | 357_E | 1.877 | 1.00 | |
| 57_V | 241_L | 1.844 | 1.00 | |
| 120_L | 135_A | 1.82 | 1.00 | |
| 128_Q | 131_R | 1.805 | 1.00 | |
| 122_V | 133_A | 1.801 | 1.00 | |
| 164_R | 170_S | 1.776 | 1.00 | |
| 234_G | 237_D | 1.762 | 1.00 | |
| 265_Y | 373_I | 1.76 | 1.00 | |
| 264_K | 281_P | 1.756 | 1.00 | |
| 369_G | 373_I | 1.755 | 1.00 | |
| 199_Y | 298_A | 1.752 | 1.00 | |
| 336_H | 339_T | 1.744 | 1.00 | |
| 172_V | 189_A | 1.741 | 1.00 | |
| 196_C | 208_A | 1.737 | 1.00 | |
| 65_E | 194_H | 1.714 | 1.00 | |
| 307_D | 310_T | 1.711 | 1.00 | |
| 170_S | 189_A | 1.702 | 1.00 | |
| 141_V | 163_A | 1.694 | 1.00 | |
| 261_A | 370_E | 1.681 | 1.00 | |
| 258_N | 369_G | 1.679 | 1.00 | |
| 73_T | 82_L | 1.666 | 1.00 | |
| 254_L | 257_R | 1.661 | 1.00 | |
| 89_K | 114_R | 1.633 | 1.00 | |
| 96_A | 108_F | 1.619 | 1.00 | |
| 304_L | 314_F | 1.617 | 1.00 | |
| 262_I | 372_L | 1.616 | 1.00 | |
| 273_K | 358_T | 1.609 | 1.00 | |
| 131_R | 166_V | 1.602 | 1.00 | |
| 261_A | 369_G | 1.6 | 1.00 | |
| 196_C | 241_L | 1.596 | 1.00 | |
| 321_F | 376_L | 1.593 | 1.00 | |
| 196_C | 210_V | 1.578 | 1.00 | |
| 93_L | 118_R | 1.576 | 1.00 | |
| 262_I | 376_L | 1.575 | 1.00 | |
| 84_T | 140_L | 1.574 | 1.00 | |
| 127_E | 162_L | 1.574 | 1.00 | |
| 176_F | 327_L | 1.573 | 1.00 | |
| 6_A | 249_V | 1.57 | 1.00 | |
| 318_L | 334_I | 1.544 | 1.00 | |
| 255_A | 298_A | 1.54 | 1.00 | |
| 347_P | 357_E | 1.527 | 1.00 | |
| 54_R | 238_S | 1.525 | 1.00 | |
| 57_V | 72_L | 1.512 | 1.00 | |
| 261_A | 264_K | 1.504 | 1.00 | |
| 157_A | 292_Q | 1.499 | 1.00 | |
| 317_G | 382_A | 1.495 | 1.00 | |
| 265_Y | 269_Q | 1.481 | 1.00 | |
| 303_E | 356_S | 1.473 | 1.00 | |
| 321_F | 372_L | 1.472 | 1.00 | |
| 160_C | 164_R | 1.472 | 1.00 | |
| 83_V | 171_V | 1.467 | 1.00 | |
| 233_G | 238_S | 1.46 | 1.00 | |
| 141_V | 159_I | 1.457 | 1.00 | |
| 313_R | 317_G | 1.453 | 1.00 | |
| 134_L | 141_V | 1.44 | 1.00 | |
| 330_V | 366_I | 1.425 | 1.00 | |
| 57_V | 210_V | 1.417 | 1.00 | |
| 93_L | 138_P | 1.415 | 1.00 | |
| 346_A | 349_A | 1.405 | 0.99 | |
| 273_K | 303_E | 1.395 | 0.99 | |
| 128_Q | 132_A | 1.387 | 0.99 | |
| 108_F | 119_V | 1.371 | 0.99 | |
| 93_L | 137_K | 1.371 | 0.99 | |
| 88_L | 94_L | 1.37 | 0.99 | |
| 12_S | 63_E | 1.367 | 0.99 | |
| 259_A | 263_V | 1.36 | 0.99 | |
| 161_H | 164_R | 1.358 | 0.99 | |
| 158_K | 161_H | 1.356 | 0.99 | |
| 262_I | 364_T | 1.355 | 0.99 | |
| 261_A | 373_I | 1.35 | 0.99 | |
| 208_A | 233_G | 1.349 | 0.99 | |
| 281_P | 286_H | 1.348 | 0.99 | |
| 171_V | 193_L | 1.339 | 0.99 | |
| 70_A | 210_V | 1.336 | 0.99 | |
| 250_P | 366_I | 1.331 | 0.99 | |
| 81_H | 85_T | 1.33 | 0.99 | |
| 200_L | 245_L | 1.325 | 0.99 | |
| 252_M | 255_A | 1.322 | 0.99 | |
| 151_L | 278_P | 1.321 | 0.99 | |
| 362_I | 376_L | 1.318 | 0.99 | |
| 143_V | 156_I | 1.312 | 0.99 | |
| 82_L | 231_V | 1.307 | 0.99 | |
| 67_G | 185_L | 1.303 | 0.99 | |
| 25_P | 56_V | 1.297 | 0.99 | |
| 44_H | 50_G | 1.296 | 0.99 | |
| 308_E | 312_R | 1.291 | 0.99 | |
| 287_E | 290_A | 1.288 | 0.99 | |
| 301_S | 359_L | 1.281 | 0.99 | |
| 112_A | 115_G | 1.281 | 0.99 | |
| 134_L | 162_L | 1.274 | 0.99 | |
| 334_I | 360_L | 1.267 | 0.99 | |
| 29_L | 236_F | 1.263 | 0.99 | |
| 61_L | 212_I | 1.261 | 0.99 | |
| 258_N | 366_I | 1.26 | 0.99 | |
| 96_A | 100_C | 1.252 | 0.99 | |
| 262_I | 369_G | 1.242 | 0.98 | |
| 157_A | 187_L | 1.238 | 0.98 | |
| 143_V | 170_S | 1.231 | 0.98 | |
| 80_I | 142_L | 1.229 | 0.98 | |
| 206_V | 241_L | 1.227 | 0.98 | |
| 70_A | 212_I | 1.225 | 0.98 | |
| 160_C | 189_A | 1.219 | 0.98 | |
| 314_F | 334_I | 1.218 | 0.98 | |
| 134_L | 168_A | 1.218 | 0.98 | |
| 34_N | 322_T | 1.217 | 0.98 | |
| 89_K | 92_D | 1.215 | 0.98 | |
| 183_N | 294_K | 1.203 | 0.98 | |
| 374_A | 377_E | 1.193 | 0.98 | |
| 118_R | 137_K | 1.191 | 0.98 | |
| 257_R | 261_A | 1.187 | 0.98 | |
| 308_E | 357_E | 1.184 | 0.98 | |
| 9_A | 249_V | 1.184 | 0.98 | |
| 83_V | 191_L | 1.181 | 0.98 | |
| 205_D | 243_R | 1.175 | 0.98 | |
| 95_V | 133_A | 1.175 | 0.98 | |
| 151_L | 300_L | 1.174 | 0.98 | |
| 62_A | 70_A | 1.17 | 0.97 | |
| 287_E | 291_R | 1.166 | 0.97 | |
| 286_H | 296_F | 1.164 | 0.97 | |
| 269_Q | 377_E | 1.162 | 0.97 | |
| 319_S | 378_N | 1.161 | 0.97 | |
| 264_K | 267_Q | 1.16 | 0.97 | |
| 196_C | 200_L | 1.157 | 0.97 | |
| 285_G | 288_I | 1.155 | 0.97 | |
| 44_H | 55_D | 1.148 | 0.97 | |
| 206_V | 237_D | 1.148 | 0.97 | |
| 283_N | 286_H | 1.144 | 0.97 | |
| 84_T | 108_F | 1.133 | 0.97 | |
| 141_V | 168_A | 1.131 | 0.97 | |
| 208_A | 241_L | 1.126 | 0.97 | |
| 180_A | 253_E | 1.122 | 0.97 | |
| 73_T | 211_V | 1.122 | 0.97 | |
| 254_L | 258_N | 1.121 | 0.97 | |
| 131_R | 162_L | 1.12 | 0.96 | |
| 47_S | 54_R | 1.113 | 0.96 | |
| 155_D | 158_K | 1.111 | 0.96 | |
| 84_T | 88_L | 1.107 | 0.96 | |
| 314_F | 360_L | 1.105 | 0.96 | |
| 159_I | 170_S | 1.1 | 0.96 | |
| 204_S | 329_G | 1.091 | 0.96 | |
| 289_A | 296_F | 1.086 | 0.96 | |
| 98_H | 152_R | 1.083 | 0.96 | |
| 320_L | 372_L | 1.082 | 0.96 | |
| 262_I | 362_I | 1.081 | 0.95 | |
| 309_Q | 312_R | 1.078 | 0.95 | |
| 182_Q | 187_L | 1.069 | 0.95 | |
| 263_V | 280_L | 1.057 | 0.95 | |
| 249_V | 253_E | 1.055 | 0.95 | |
| 193_L | 211_V | 1.053 | 0.95 | |
| 375_D | 378_N | 1.048 | 0.94 | |
| 274_K | 358_T | 1.046 | 0.94 | |
| 125_G | 285_G | 1.045 | 0.94 | |
| 60_A | 245_L | 1.042 | 0.94 | |
| 37_G | 316_G | 1.041 | 0.94 | |
| 267_Q | 280_L | 1.04 | 0.94 | |
| 27_I | 239_Y | 1.036 | 0.94 | |
| 23_V | 322_T | 1.03 | 0.94 | |
| 201_N | 206_V | 1.027 | 0.94 | |
| 314_F | 376_L | 1.026 | 0.94 | |
| 177_L | 293_Q | 1.025 | 0.93 | |
| 163_A | 170_S | 1.024 | 0.93 | |
| 4_K | 368_D | 1.016 | 0.93 | |
| 27_I | 236_F | 1.016 | 0.93 | |
| 271_L | 380_F | 1.014 | 0.93 | |
| 130_L | 159_I | 1.012 | 0.93 | |
| 143_V | 172_V | 1.011 | 0.93 | |
| 263_V | 275_L | 1.007 | 0.93 | |
| 83_V | 211_V | 1.006 | 0.93 | |
| 61_L | 200_L | 1.006 | 0.93 | |
| 78_S | 231_V | 1.003 | 0.93 | |
| 88_L | 92_D | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1ibjA | 2 | 0.9896 | 100 | 0.385 | Contact Map | 0.778 |
| 1qgnA | 8 | 0.9896 | 100 | 0.402 | Contact Map | 0.775 |
| 3cogA | 4 | 0.9974 | 100 | 0.425 | Contact Map | 0.856 |
| 3ri6A | 2 | 0.9793 | 100 | 0.427 | Contact Map | 0.74 |
| 3nmyA | 4 | 0.9922 | 100 | 0.435 | Contact Map | 0.82 |
| 2fq6A | 2 | 0.987 | 100 | 0.436 | Contact Map | 0.758 |
| 4kamA | 4 | 1 | 100 | 0.446 | Contact Map | 0.814 |
| 1e5eA | 2 | 0.9974 | 100 | 0.462 | Contact Map | 0.832 |
| 3ndnA | 4 | 0.9819 | 100 | 0.48 | Contact Map | 0.748 |
| 2rfvA | 1 | 0.9948 | 100 | 0.5 | Contact Map | 0.802 |
Sequence Conservation (Image Generated using WebLogo v3)