| UniProt: | P06721 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10583 | ||
| Length: | 395 (385) | ||
| Sequences: | 5087 | ||
| Seq/Len: | 13.21 |
| METC
Paralog alert: 0.82 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: METB METC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 195_K | 198_D | 4.012 | 1.00 | |
| 278_A | 293_G | 3.63 | 1.00 | |
| 141_V | 175_S | 3.553 | 1.00 | |
| 7_D | 379_D | 3.532 | 1.00 | |
| 103_H | 130_S | 3.26 | 1.00 | |
| 271_L | 275_E | 3.099 | 1.00 | |
| 77_G | 224_V | 3.031 | 1.00 | |
| 388_D | 392_A | 2.914 | 1.00 | |
| 103_H | 145_Q | 2.819 | 1.00 | |
| 167_P | 171_A | 2.718 | 1.00 | |
| 334_F | 345_S | 2.674 | 1.00 | |
| 71_M | 222_T | 2.664 | 1.00 | |
| 76_G | 198_D | 2.602 | 1.00 | |
| 284_A | 316_K | 2.563 | 1.00 | |
| 285_R | 314_V | 2.487 | 1.00 | |
| 150_I | 183_M | 2.48 | 1.00 | |
| 167_P | 302_R | 2.42 | 1.00 | |
| 65_F | 69_Q | 2.273 | 1.00 | |
| 9_Q | 73_E | 2.241 | 1.00 | |
| 297_H | 301_K | 2.206 | 1.00 | |
| 170_V | 182_I | 2.187 | 1.00 | |
| 276_W | 388_D | 2.163 | 1.00 | |
| 314_V | 369_T | 2.105 | 1.00 | |
| 128_T | 145_Q | 2.101 | 1.00 | |
| 264_R | 268_E | 2.098 | 1.00 | |
| 102_D | 149_K | 2.096 | 1.00 | |
| 137_G | 168_A | 2.066 | 1.00 | |
| 136_I | 139_D | 2.043 | 1.00 | |
| 40_E | 44_H | 2.026 | 1.00 | |
| 273_V | 384_I | 1.962 | 1.00 | |
| 193_L | 267_H | 1.961 | 1.00 | |
| 174_R | 202_D | 1.941 | 1.00 | |
| 164_H | 169_I | 1.934 | 1.00 | |
| 171_A | 175_S | 1.895 | 1.00 | |
| 67_L | 252_T | 1.894 | 1.00 | |
| 99_E | 124_K | 1.876 | 1.00 | |
| 130_S | 145_Q | 1.856 | 1.00 | |
| 132_F | 143_H | 1.844 | 1.00 | |
| 245_D | 248_T | 1.843 | 1.00 | |
| 184_I | 201_I | 1.841 | 1.00 | |
| 275_E | 292_P | 1.799 | 1.00 | |
| 211_Y | 309_G | 1.795 | 1.00 | |
| 276_W | 384_I | 1.769 | 1.00 | |
| 380_V | 384_I | 1.756 | 1.00 | |
| 138_A | 141_V | 1.752 | 1.00 | |
| 208_A | 220_I | 1.742 | 1.00 | |
| 174_R | 182_I | 1.735 | 1.00 | |
| 272_K | 381_D | 1.713 | 1.00 | |
| 182_I | 201_I | 1.707 | 1.00 | |
| 151_V | 173_V | 1.689 | 1.00 | |
| 103_H | 128_T | 1.688 | 1.00 | |
| 7_D | 260_G | 1.673 | 1.00 | |
| 269_S | 380_V | 1.67 | 1.00 | |
| 83_F | 92_N | 1.664 | 1.00 | |
| 75_E | 206_Q | 1.661 | 1.00 | |
| 315_L | 327_Y | 1.651 | 1.00 | |
| 265_Q | 268_E | 1.63 | 1.00 | |
| 320_N | 323_E | 1.63 | 1.00 | |
| 106_M | 118_C | 1.625 | 1.00 | |
| 141_V | 178_P | 1.62 | 1.00 | |
| 137_G | 172_A | 1.62 | 1.00 | |
| 334_F | 387_L | 1.618 | 1.00 | |
| 273_V | 383_L | 1.608 | 1.00 | |
| 284_A | 369_T | 1.594 | 1.00 | |
| 272_K | 380_V | 1.582 | 1.00 | |
| 208_A | 252_T | 1.575 | 1.00 | |
| 188_W | 340_W | 1.572 | 1.00 | |
| 266_H | 309_G | 1.572 | 1.00 | |
| 67_L | 82_L | 1.562 | 1.00 | |
| 94_I | 150_I | 1.55 | 1.00 | |
| 208_A | 222_T | 1.548 | 1.00 | |
| 64_H | 249_A | 1.547 | 1.00 | |
| 273_V | 387_L | 1.54 | 1.00 | |
| 331_F | 347_I | 1.537 | 1.00 | |
| 330_N | 393_R | 1.535 | 1.00 | |
| 6_L | 192_V | 1.51 | 1.00 | |
| 272_K | 275_E | 1.502 | 1.00 | |
| 314_V | 367_S | 1.499 | 1.00 | |
| 276_W | 280_H | 1.498 | 1.00 | |
| 167_P | 303_D | 1.497 | 1.00 | |
| 334_F | 383_L | 1.497 | 1.00 | |
| 170_V | 174_R | 1.477 | 1.00 | |
| 151_V | 169_I | 1.474 | 1.00 | |
| 349_A | 354_H | 1.472 | 1.00 | |
| 244_V | 249_A | 1.465 | 1.00 | |
| 175_S | 178_P | 1.46 | 1.00 | |
| 93_S | 183_M | 1.456 | 1.00 | |
| 343_Y | 377_L | 1.451 | 1.00 | |
| 103_H | 147_N | 1.42 | 1.00 | |
| 118_C | 129_T | 1.419 | 1.00 | |
| 326_N | 330_N | 1.418 | 1.00 | |
| 220_I | 244_V | 1.415 | 1.00 | |
| 37_D | 41_A | 1.406 | 0.99 | |
| 144_L | 151_V | 1.406 | 0.99 | |
| 273_V | 375_I | 1.398 | 0.99 | |
| 67_L | 222_T | 1.389 | 0.99 | |
| 13_A | 73_E | 1.388 | 0.99 | |
| 284_A | 314_V | 1.384 | 0.99 | |
| 263_L | 266_H | 1.377 | 0.99 | |
| 270_S | 274_A | 1.374 | 0.99 | |
| 138_A | 142_K | 1.373 | 0.99 | |
| 103_H | 148_T | 1.371 | 0.99 | |
| 212_L | 256_L | 1.358 | 0.99 | |
| 161_M | 289_P | 1.358 | 0.99 | |
| 272_K | 384_I | 1.354 | 0.99 | |
| 292_P | 297_H | 1.354 | 0.99 | |
| 183_M | 205_I | 1.353 | 0.99 | |
| 171_A | 174_R | 1.349 | 0.99 | |
| 77_G | 197_L | 1.341 | 0.99 | |
| 54_L | 60_G | 1.336 | 0.99 | |
| 80_C | 222_T | 1.324 | 0.99 | |
| 261_V | 377_L | 1.324 | 0.99 | |
| 153_L | 166_V | 1.322 | 0.99 | |
| 168_A | 171_A | 1.319 | 0.99 | |
| 98_I | 104_V | 1.319 | 0.99 | |
| 321_N | 368_G | 1.317 | 0.99 | |
| 373_L | 387_L | 1.312 | 0.99 | |
| 312_S | 370_L | 1.31 | 0.99 | |
| 321_N | 325_A | 1.308 | 0.99 | |
| 347_I | 371_I | 1.302 | 0.99 | |
| 92_N | 242_Q | 1.3 | 0.99 | |
| 44_H | 50_A | 1.299 | 0.99 | |
| 269_S | 377_L | 1.297 | 0.99 | |
| 106_M | 110_A | 1.288 | 0.99 | |
| 71_M | 224_V | 1.283 | 0.99 | |
| 273_V | 380_V | 1.278 | 0.99 | |
| 298_E | 301_K | 1.276 | 0.99 | |
| 153_L | 182_I | 1.273 | 0.99 | |
| 144_L | 172_A | 1.27 | 0.99 | |
| 30_R | 247_D | 1.265 | 0.99 | |
| 5_K | 379_D | 1.264 | 0.99 | |
| 26_S | 66_S | 1.264 | 0.99 | |
| 91_A | 95_L | 1.247 | 0.99 | |
| 144_L | 180_A | 1.244 | 0.98 | |
| 90_V | 152_F | 1.242 | 0.98 | |
| 80_C | 224_V | 1.238 | 0.98 | |
| 327_Y | 347_I | 1.231 | 0.98 | |
| 268_E | 272_K | 1.23 | 0.98 | |
| 332_S | 389_A | 1.226 | 0.98 | |
| 99_E | 102_D | 1.221 | 0.98 | |
| 167_P | 199_F | 1.218 | 0.98 | |
| 297_H | 307_S | 1.214 | 0.98 | |
| 218_A | 252_T | 1.213 | 0.98 | |
| 170_V | 201_I | 1.212 | 0.98 | |
| 218_A | 248_T | 1.206 | 0.98 | |
| 296_G | 299_F | 1.19 | 0.98 | |
| 385_A | 388_D | 1.19 | 0.98 | |
| 298_E | 302_R | 1.188 | 0.98 | |
| 141_V | 172_A | 1.182 | 0.98 | |
| 35_V | 335_S | 1.175 | 0.98 | |
| 220_I | 252_T | 1.17 | 0.97 | |
| 151_V | 180_A | 1.168 | 0.97 | |
| 83_F | 223_A | 1.167 | 0.97 | |
| 72_C | 80_C | 1.167 | 0.97 | |
| 128_T | 147_N | 1.167 | 0.97 | |
| 10_L | 260_G | 1.161 | 0.97 | |
| 327_Y | 371_I | 1.158 | 0.97 | |
| 275_E | 278_A | 1.154 | 0.97 | |
| 294_S | 297_H | 1.152 | 0.97 | |
| 208_A | 212_L | 1.151 | 0.97 | |
| 195_K | 305_T | 1.147 | 0.97 | |
| 93_S | 203_V | 1.144 | 0.97 | |
| 265_Q | 269_S | 1.137 | 0.97 | |
| 161_M | 311_F | 1.137 | 0.97 | |
| 192_V | 264_R | 1.135 | 0.97 | |
| 105_L | 143_H | 1.135 | 0.97 | |
| 280_H | 388_D | 1.131 | 0.97 | |
| 108_N | 162_E | 1.127 | 0.97 | |
| 217_D | 254_R | 1.125 | 0.97 | |
| 165_D | 168_A | 1.115 | 0.96 | |
| 57_G | 64_H | 1.108 | 0.96 | |
| 41_A | 45_A | 1.107 | 0.96 | |
| 105_L | 132_F | 1.107 | 0.96 | |
| 169_I | 182_I | 1.105 | 0.96 | |
| 94_I | 98_I | 1.096 | 0.96 | |
| 98_I | 102_D | 1.095 | 0.96 | |
| 285_R | 369_T | 1.09 | 0.96 | |
| 333_L | 383_L | 1.09 | 0.96 | |
| 173_V | 182_I | 1.087 | 0.96 | |
| 322_E | 325_A | 1.084 | 0.96 | |
| 38_S | 329_D | 1.079 | 0.95 | |
| 70_A | 256_L | 1.077 | 0.95 | |
| 273_V | 373_L | 1.074 | 0.95 | |
| 274_A | 291_L | 1.067 | 0.95 | |
| 54_L | 65_F | 1.065 | 0.95 | |
| 300_W | 304_F | 1.061 | 0.95 | |
| 386_D | 389_A | 1.061 | 0.95 | |
| 213_V | 218_A | 1.061 | 0.95 | |
| 194_F | 199_F | 1.059 | 0.95 | |
| 94_I | 118_C | 1.053 | 0.95 | |
| 216_S | 342_G | 1.049 | 0.94 | |
| 260_G | 264_R | 1.046 | 0.94 | |
| 300_W | 307_S | 1.044 | 0.94 | |
| 278_A | 291_L | 1.042 | 0.94 | |
| 327_Y | 387_L | 1.041 | 0.94 | |
| 22_G | 37_D | 1.04 | 0.94 | |
| 225_C | 230_W | 1.037 | 0.94 | |
| 166_V | 201_I | 1.033 | 0.94 | |
| 44_H | 51_N | 1.031 | 0.94 | |
| 301_K | 307_S | 1.03 | 0.94 | |
| 88_A | 242_Q | 1.03 | 0.94 | |
| 153_L | 184_I | 1.028 | 0.94 | |
| 205_I | 223_A | 1.027 | 0.94 | |
| 135_L | 296_G | 1.025 | 0.93 | |
| 282_Q | 391_F | 1.022 | 0.93 | |
| 140_I | 169_I | 1.021 | 0.93 | |
| 166_V | 182_I | 1.021 | 0.93 | |
| 71_M | 212_L | 1.019 | 0.93 | |
| 59_R | 238_Y | 1.018 | 0.93 | |
| 40_E | 329_D | 1.016 | 0.93 | |
| 267_H | 271_L | 1.012 | 0.93 | |
| 11_V | 377_L | 1.008 | 0.93 | |
| 28_I | 250_Y | 1.005 | 0.93 | |
| 387_L | 391_F | 1.005 | 0.93 | |
| 106_M | 129_T | 1.004 | 0.93 | |
| 134_P | 140_I | 1.004 | 0.93 | |
| 28_I | 247_D | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1ibjA | 2 | 0.9544 | 100 | 0.406 | Contact Map | 0.785 |
| 1qgnA | 8 | 0.9797 | 100 | 0.407 | Contact Map | 0.764 |
| 2fq6A | 2 | 1 | 100 | 0.421 | Contact Map | 0.748 |
| 3ri6A | 2 | 0.9696 | 100 | 0.432 | Contact Map | 0.737 |
| 3cogA | 4 | 0.9595 | 100 | 0.443 | Contact Map | 0.858 |
| 4kamA | 4 | 0.9823 | 100 | 0.454 | Contact Map | 0.819 |
| 3nmyA | 4 | 0.9595 | 100 | 0.455 | Contact Map | 0.816 |
| 1e5eA | 2 | 0.9797 | 100 | 0.467 | Contact Map | 0.831 |
| 3ndnA | 4 | 0.9772 | 100 | 0.484 | Contact Map | 0.757 |
| 2rfvA | 1 | 0.9823 | 100 | 0.502 | Contact Map | 0.8 |
Sequence Conservation (Image Generated using WebLogo v3)