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OPENSEQ.org
KHSE - Homoserine kinase
UniProt: P00547 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10999
Length: 310 (306)
Sequences: 4617
Seq/Len: 15.09
KHSE
Paralog alert: 0.76 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ISPE KHSE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
39_E 83_A 3.981 1.00
45_S 83_A 3.944 1.00
5_Y 33_G 3.799 1.00
119_N 122_R 3.797 1.00
107_L 123_L 3.058 1.00
59_E 62_E 3.055 1.00
6_A 102_S 2.956 1.00
38_V 109_A 2.823 1.00
218_Q 221_L 2.731 1.00
270_C 279_V 2.662 1.00
35_V 87_E 2.589 1.00
47_N 85_T 2.527 1.00
41_A 83_A 2.495 1.00
111_N 117_P 2.44 1.00
47_N 83_A 2.35 1.00
247_Q 251_E 2.257 1.00
132_G 157_E 2.235 1.00
37_T 85_T 2.234 1.00
257_S 268_A 2.14 1.00
108_M 305_A 2.095 1.00
72_F 116_K 2.091 1.00
75_E 129_E 2.071 1.00
71_R 129_E 2.064 1.00
3_K 37_T 2.003 1.00
44_F 81_P 2.003 1.00
223_A 256_A 1.999 1.00
273_P 277_Q 1.967 1.00
242_F 266_L 1.938 1.00
70_E 74_Q 1.936 1.00
175_L 265_T 1.913 1.00
6_A 105_A 1.845 1.00
174_V 270_C 1.816 1.00
303_A 306_R 1.804 1.00
210_F 222_A 1.803 1.00
111_N 116_K 1.78 1.00
111_N 118_L 1.759 1.00
226_M 256_A 1.726 1.00
36_V 105_A 1.714 1.00
75_E 122_R 1.704 1.00
212_H 216_S 1.703 1.00
4_V 112_E 1.702 1.00
232_E 246_R 1.69 1.00
71_R 75_E 1.686 1.00
227_K 250_A 1.663 1.00
182_V 262_S 1.654 1.00
174_V 279_V 1.637 1.00
41_A 81_P 1.62 1.00
243_R 247_Q 1.61 1.00
124_L 148_L 1.602 1.00
173_W 269_L 1.582 1.00
72_F 107_L 1.567 1.00
5_Y 35_V 1.56 1.00
180_I 241_G 1.556 1.00
38_V 84_M 1.552 1.00
163_Q 215_Y 1.542 1.00
277_Q 280_A 1.541 1.00
281_D 285_K 1.537 1.00
71_R 126_L 1.536 1.00
49_L 87_E 1.533 1.00
37_T 87_E 1.516 1.00
172_L 272_K 1.503 1.00
231_A 235_R 1.495 1.00
6_A 305_A 1.484 1.00
236_E 243_R 1.48 1.00
122_R 125_A 1.471 1.00
221_L 224_K 1.452 1.00
72_F 114_C 1.442 1.00
61_R 70_E 1.424 1.00
176_A 245_A 1.414 1.00
69_W 110_M 1.413 1.00
183_S 186_E 1.409 1.00
70_E 73_C 1.398 0.99
272_K 275_T 1.397 0.99
8_A 90_M 1.392 0.99
4_V 109_A 1.391 0.99
40_A 80_I 1.389 0.99
75_E 126_L 1.386 0.99
248_A 252_I 1.372 0.99
34_D 101_C 1.367 0.99
271_D 275_T 1.365 0.99
154_M 162_S 1.363 0.99
66_Y 70_E 1.355 0.99
246_R 266_L 1.34 0.99
220_E 271_D 1.339 0.99
258_G 267_F 1.331 0.99
246_R 257_S 1.317 0.99
190_I 238_L 1.316 0.99
185_A 189_A 1.315 0.99
213_A 218_Q 1.31 0.99
65_V 86_L 1.31 0.99
177_Y 265_T 1.309 0.99
104_V 147_F 1.306 0.99
10_S 22_A 1.304 0.99
205_R 209_G 1.302 0.99
280_A 284_G 1.285 0.99
277_Q 281_D 1.275 0.99
65_V 106_A 1.273 0.99
57_P 62_E 1.268 0.99
249_V 268_A 1.264 0.99
76_L 118_L 1.255 0.99
124_L 147_F 1.246 0.98
9_S 146_C 1.236 0.98
175_L 267_F 1.234 0.98
111_N 123_L 1.231 0.98
30_A 132_G 1.222 0.98
187_A 231_A 1.215 0.98
108_M 123_L 1.208 0.98
39_E 85_T 1.204 0.98
248_A 251_E 1.193 0.98
106_A 110_M 1.166 0.97
49_L 85_T 1.164 0.97
186_E 189_A 1.158 0.97
44_F 82_V 1.152 0.97
176_A 268_A 1.146 0.97
93_G 181_K 1.143 0.97
71_R 74_Q 1.135 0.97
288_L 292_E 1.133 0.97
72_F 110_M 1.127 0.97
213_A 222_A 1.125 0.97
25_T 299_R 1.118 0.96
33_G 90_M 1.105 0.96
172_L 276_A 1.102 0.96
86_L 102_S 1.102 0.96
213_A 221_L 1.097 0.96
172_L 273_P 1.094 0.96
230_I 237_R 1.089 0.96
179_G 294_F 1.088 0.96
244_Q 247_Q 1.088 0.96
111_N 119_N 1.076 0.95
252_I 282_W 1.075 0.95
212_H 215_Y 1.073 0.95
254_A 270_C 1.064 0.95
275_T 278_R 1.049 0.94
242_F 259_I 1.048 0.94
249_V 254_A 1.045 0.94
68_C 107_L 1.044 0.94
22_A 300_L 1.044 0.94
150_G 164_Q 1.04 0.94
244_Q 248_A 1.035 0.94
68_C 130_L 1.031 0.94
35_V 89_N 1.031 0.94
220_E 224_K 1.03 0.94
182_V 187_A 1.03 0.94
34_D 88_K 1.027 0.94
38_V 82_V 1.027 0.94
170_E 272_K 1.022 0.93
268_A 279_V 1.022 0.93
36_V 106_A 1.017 0.93
252_I 279_V 1.017 0.93
121_T 125_A 1.012 0.93
84_M 106_A 1.011 0.93
110_M 114_C 1.01 0.93
9_S 145_P 1.01 0.93
5_Y 306_R 1.008 0.93
94_S 177_Y 1.005 0.93
182_V 235_R 1 0.92
249_V 279_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1h72C10.93551000.182Contact Map0.773
3pyfA10.92581000.233Contact Map0.753
3hulA20.92261000.234Contact Map0.73
1pieA10.96451000.248Contact Map0.738
2cz9A10.95481000.26Contact Map0.77
2a2cA10.96131000.27Contact Map0.724
1wuuA40.95161000.28Contact Map0.751
4hacA20.91941000.285Contact Map0.796
3k85A20.95811000.286Contact Map0.737
4n3oA20.95811000.289Contact Map0.767
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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