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ISPE - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
UniProt: P62615 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11294
Length: 283 (266)
Sequences: 2767
Seq/Len: 10.40
ISPE
Paralog alert: 0.56 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ISPE KHSE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_S 110_N 3.887 1.00
44_E 91_N 3.551 1.00
140_A 156_V 3.371 1.00
115_L 131_L 3.068 1.00
52_R 91_N 3.043 1.00
127_S 130_E 2.954 1.00
40_T 95_D 2.861 1.00
212_E 226_L 2.841 1.00
248_F 257_V 2.528 1.00
29_Q 152_F 2.4 1.00
43_I 117_A 2.33 1.00
132_A 147_R 2.253 1.00
73_L 137_T 2.214 1.00
54_L 93_S 2.188 1.00
74_L 124_C 2.133 1.00
73_L 134_M 2.085 1.00
172_V 243_C 2.008 1.00
61_E 64_D 1.994 1.00
184_I 211_C 1.981 1.00
74_L 115_L 1.978 1.00
251_E 255_R 1.969 1.00
119_N 126_L 1.951 1.00
216_R 223_D 1.932 1.00
6_P 38_G 1.916 1.00
250_T 253_E 1.832 1.00
30_T 153_A 1.83 1.00
171_L 248_F 1.827 1.00
222_V 244_V 1.815 1.00
42_S 95_D 1.783 1.00
119_N 125_G 1.777 1.00
73_L 77_T 1.775 1.00
187_D 218_R 1.773 1.00
170_Y 247_E 1.758 1.00
29_Q 154_E 1.731 1.00
74_L 122_W 1.725 1.00
182_P 186_K 1.715 1.00
63_E 72_R 1.706 1.00
42_S 93_S 1.698 1.00
41_I 114_V 1.688 1.00
236_R 245_F 1.686 1.00
77_T 137_T 1.674 1.00
72_R 76_K 1.646 1.00
179_I 215_A 1.644 1.00
43_I 92_I 1.634 1.00
68_V 72_R 1.621 1.00
46_R 91_N 1.614 1.00
223_D 227_S 1.593 1.00
226_L 244_V 1.585 1.00
51_I 68_V 1.572 1.00
33_Q 150_A 1.571 1.00
183_V 186_K 1.564 1.00
227_S 231_E 1.524 1.00
67_I 114_V 1.516 1.00
54_L 91_N 1.501 1.00
7_S 113_T 1.479 1.00
41_I 113_T 1.474 1.00
119_N 127_S 1.466 1.00
25_Y 140_A 1.45 1.00
77_T 130_E 1.443 1.00
43_I 114_V 1.441 1.00
28_L 185_F 1.439 1.00
5_W 117_A 1.429 1.00
118_L 122_W 1.427 1.00
174_H 243_C 1.402 0.99
179_I 184_I 1.399 0.99
4_Q 42_S 1.398 0.99
44_E 93_S 1.392 0.99
153_A 160_L 1.386 0.99
77_T 134_M 1.38 0.99
32_F 153_A 1.36 0.99
72_R 75_M 1.352 0.99
6_P 40_T 1.34 0.99
71_A 92_I 1.327 0.99
177_V 221_E 1.315 0.99
67_I 94_I 1.314 0.99
66_L 111_A 1.308 0.99
10_K 145_F 1.306 0.99
212_E 216_R 1.303 0.99
70_A 138_L 1.298 0.99
85_P 88_S 1.284 0.99
101_G 178_S 1.281 0.99
172_V 245_F 1.26 0.99
46_R 49_G 1.259 0.99
101_G 243_C 1.242 0.98
130_E 133_E 1.24 0.98
154_E 161_T 1.236 0.98
117_A 121_L 1.223 0.98
119_N 124_C 1.219 0.98
169_W 251_E 1.219 0.98
180_P 183_V 1.203 0.98
120_H 124_C 1.202 0.98
171_L 257_V 1.191 0.98
31_L 163_V 1.187 0.98
66_L 138_L 1.187 0.98
102_G 174_H 1.179 0.98
179_I 240_T 1.176 0.98
109_S 145_F 1.173 0.98
98_L 109_S 1.162 0.97
53_L 60_V 1.161 0.97
119_N 131_L 1.158 0.97
235_S 246_A 1.151 0.97
40_T 97_R 1.15 0.97
81_S 126_L 1.143 0.97
71_A 75_M 1.14 0.97
126_L 130_E 1.138 0.97
10_K 144_V 1.125 0.97
184_I 215_A 1.116 0.96
71_A 118_L 1.11 0.96
114_V 118_L 1.105 0.96
45_L 88_S 1.101 0.96
216_R 222_V 1.099 0.96
39_D 98_L 1.098 0.96
228_W 232_Y 1.098 0.96
41_I 67_I 1.098 0.96
222_V 237_L 1.09 0.96
173_A 225_V 1.086 0.96
135_G 142_V 1.081 0.95
229_L 246_A 1.079 0.95
216_R 226_L 1.078 0.95
17_I 188_P 1.076 0.95
73_L 138_L 1.069 0.95
5_W 116_V 1.069 0.95
19_G 27_T 1.068 0.95
144_V 185_F 1.062 0.95
171_L 254_A 1.06 0.95
46_R 52_R 1.058 0.95
183_V 218_R 1.054 0.95
75_M 122_W 1.041 0.94
9_A 98_L 1.038 0.94
11_L 238_T 1.038 0.94
16_Y 210_D 1.037 0.94
198_S 201_T 1.037 0.94
92_I 114_V 1.036 0.94
5_W 113_T 1.035 0.94
135_G 146_V 1.034 0.94
246_A 257_V 1.027 0.94
81_S 84_L 1.025 0.93
39_D 96_K 1.021 0.93
126_L 134_M 1.021 0.93
53_L 65_N 1.017 0.93
98_L 104_L 1.016 0.93
101_G 242_A 1.016 0.93
14_F 199_I 1.014 0.93
128_M 147_R 1.011 0.93
18_T 27_T 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ww4A20.98231000.267Contact Map0.806
2v8pA20.91871000.295Contact Map0.776
1uekA10.93991000.315Contact Map0.75
3pyfA10.97531000.332Contact Map0.736
3hulA20.91171000.42Contact Map0.59
3ltoA20.95411000.435Contact Map0.54
1h72C10.91171000.436Contact Map0.689
2gs8A10.95051000.454Contact Map0.554
4hacA20.90811000.496Contact Map0.729
1kkhA10.91871000.497Contact Map0.677
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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