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OPENSEQ.org

SODM - Superoxide dismutase [Mn]
UniProt: P00448 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10953
Length: 206 (200)
Sequences: 2213
Seq/Len: 11.06

SODM
Paralog alert: 0.40 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: SODF SODM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_Q 37_N 4.634 1.00
181_R 184_D 3.066 1.00
112_N 115_A 3.033 1.00
99_L 199_A 2.745 1.00
197_E 200_A 2.655 1.00
38_N 41_A 2.53 1.00
167_L 186_I 2.438 1.00
100_K 104_E 2.406 1.00
135_K 140_A 2.387 1.00
101_A 104_E 2.337 1.00
22_Q 179_Q 2.318 1.00
197_E 201_R 2.282 1.00
21_K 25_E 2.282 1.00
115_A 119_K 2.13 1.00
121_A 130_A 2.125 1.00
102_A 202_F 2.113 1.00
112_N 116_E 2.112 1.00
19_F 85_F 2.081 1.00
18_H 191_N 2.049 1.00
184_D 187_K 2.017 1.00
121_A 167_L 1.981 1.00
20_D 177_K 1.949 1.00
12_Y 29_T 1.914 1.00
36_V 79_H 1.907 1.00
53_P 56_E 1.895 1.00
41_A 44_E 1.892 1.00
37_N 41_A 1.883 1.00
106_D 138_K 1.84 1.00
119_K 123_S 1.833 1.00
122_A 186_I 1.796 1.00
89_L 189_F 1.793 1.00
124_R 143_S 1.79 1.00
165_M 198_A 1.785 1.00
102_A 105_R 1.743 1.00
87_K 197_E 1.726 1.00
118_E 187_K 1.654 1.00
199_A 203_A 1.645 1.00
133_V 142_V 1.615 1.00
121_A 186_I 1.606 1.00
113_F 117_F 1.581 1.00
13_D 21_K 1.564 1.00
176_L 179_Q 1.561 1.00
4_T 7_S 1.549 1.00
79_H 83_S 1.546 1.00
116_E 119_K 1.539 1.00
88_G 198_A 1.488 1.00
111_D 114_K 1.484 1.00
39_A 76_A 1.484 1.00
32_H 86_W 1.482 1.00
118_E 122_A 1.468 1.00
94_T 111_D 1.452 1.00
196_D 199_A 1.433 1.00
6_P 83_S 1.425 1.00
98_D 203_A 1.408 1.00
167_L 189_F 1.394 0.99
200_A 204_A 1.383 0.99
117_F 167_L 1.362 0.99
52_L 60_K 1.362 0.99
22_Q 25_E 1.356 0.99
38_N 75_N 1.337 0.99
24_M 85_F 1.302 0.99
11_A 14_A 1.299 0.99
118_E 186_I 1.293 0.99
124_R 130_A 1.284 0.99
25_E 29_T 1.283 0.99
5_L 28_H 1.278 0.99
101_A 105_R 1.263 0.99
133_V 140_A 1.262 0.99
110_V 113_F 1.261 0.99
169_V 182_R 1.248 0.99
131_W 144_T 1.238 0.98
98_D 101_A 1.233 0.98
135_K 161_G 1.224 0.98
122_A 183_P 1.211 0.98
190_W 193_V 1.209 0.98
178_F 188_E 1.208 0.98
87_K 201_R 1.206 0.98
134_L 202_F 1.191 0.98
102_A 106_D 1.184 0.98
98_D 199_A 1.176 0.98
39_A 72_L 1.174 0.98
115_A 187_K 1.171 0.98
174_Y 182_R 1.16 0.97
3_Y 39_A 1.152 0.97
189_F 193_V 1.147 0.97
113_F 141_V 1.146 0.97
77_G 147_Q 1.14 0.97
12_Y 28_H 1.126 0.97
193_V 198_A 1.124 0.97
107_F 116_E 1.12 0.96
96_Q 199_A 1.117 0.96
164_I 198_A 1.095 0.96
23_T 177_K 1.087 0.96
30_K 181_R 1.084 0.96
34_T 38_N 1.078 0.95
9_P 87_K 1.068 0.95
109_S 112_N 1.064 0.95
52_L 56_E 1.06 0.95
12_Y 25_E 1.054 0.95
99_L 103_I 1.051 0.94
12_Y 21_K 1.049 0.94
114_K 191_N 1.048 0.94
117_F 189_F 1.047 0.94
85_F 185_Y 1.046 0.94
99_L 198_A 1.045 0.94
44_E 50_A 1.045 0.94
120_A 141_V 1.044 0.94
118_E 190_W 1.043 0.94
26_I 179_Q 1.043 0.94
140_A 161_G 1.04 0.94
94_T 104_E 1.024 0.93
3_Y 43_L 1.02 0.93
130_A 143_S 1.02 0.93
80_A 149_S 1.014 0.93
45_S 50_A 1.005 0.93
84_L 197_E 1.004 0.93
120_A 130_A 1.002 0.92
94_T 100_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gv3A20.9709100-0.023Contact Map0.782
3tjtA10.9709100-0.022Contact Map0.75
2rcvA80.9709100-0.02Contact Map0.806
1mngA20.966100-0.019Contact Map0.777
1xreA20.9709100-0.013Contact Map0.811
1ix9A20.9854100-0.01Contact Map0.734
3kkyA20.9951100-0.01Contact Map0.801
2cw2A20.9321000.007Contact Map0.797
2awpA20.9321000.008Contact Map0.781
3tqjA20.9321000.01Contact Map0.8

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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