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OPENSEQ.org

HPPK - HPRT
UniProt: P26281 - P0A9M2
Length: 337
Sequences: 286
Seq/Len: 0.86
I_Prob: 0.01

HPPK - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Paralog alert: 0.11 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HPPK
HPRT - Hypoxanthine phosphoribosyltransferase
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HPRT
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
51_Q 168_P 1.49 0.01
47_G 43_R 1.43 0.01
46_L 166_H 1.35 0.01
7_A 50_A 1.32 0.01
51_Q 169_Y 1.18 0.00
119_M 130_D 1.18 0.00
75_Q 116_S 1.09 0.00
151_R 90_I 1.09 0.00
129_L 130_D 1.08 0.00
50_D 12_A 1.08 0.00
39_S 124_A 1.07 0.00
114_V 154_V 1.05 0.00
129_L 110_K 1.04 0.00
46_L 63_D 1.03 0.00
15_P 126_C 1.03 0.00
15_P 17_R 1.03 0.00
42_R 28_R 1.01 0.00
81_Q 88_E 1.00 0.00
46_L 52_L 0.99 0.00
7_A 63_D 0.96 0.00
104_N 7_V 0.96 0.00
30_P 102_I 0.96 0.00
14_S 14_I 0.96 0.00
74_T 46_F 0.92 0.00
59_V 9_I 0.91 0.00
136_L 35_D 0.91 0.00
19_V 143_F 0.91 0.00
132_I 133_S 0.91 0.00
148_L 90_I 0.91 0.00
134_P 141_V 0.91 0.00
90_W 129_L 0.90 0.00
79_L 163_R 0.90 0.00
147_I 47_M 0.90 0.00
55_L 43_R 0.90 0.00
123_G 93_K 0.89 0.00
44_P 170_I 0.89 0.00
94_T 82_I 0.89 0.00
5_Y 130_D 0.89 0.00
77_I 50_A 0.88 0.00
131_E 90_I 0.88 0.00
42_R 143_F 0.88 0.00
129_L 22_G 0.88 0.00
6_I 123_L 0.87 0.00
117_Y 173_V 0.87 0.00
119_M 114_I 0.87 0.00
123_G 86_L 0.87 0.00
65_L 50_A 0.87 0.00
48_P 54_R 0.87 0.00
58_A 39_V 0.87 0.00
110_E 15_K 0.86 0.00
47_G 126_C 0.86 0.00
66_A 21_L 0.86 0.00
70_L 88_E 0.86 0.00
41_Y 135_R 0.86 0.00
99_I 7_V 0.85 0.00
113_T 13_E 0.85 0.00
24_K 21_L 0.85 0.00
57_A 104_S 0.85 0.00
106_V 170_I 0.84 0.00
15_P 21_L 0.83 0.00
99_I 57_Q 0.83 0.00
129_L 134_R 0.83 0.00
119_M 110_K 0.83 0.00
135_E 50_A 0.83 0.00
5_Y 110_K 0.83 0.00
7_A 92_G 0.83 0.00
63_T 137_V 0.82 0.00
146_Q 11_E 0.82 0.00
67_P 133_S 0.82 0.00
52_P 73_G 0.82 0.00
70_L 63_D 0.82 0.00
52_P 148_I 0.81 0.00
92_P 94_D 0.81 0.00
44_P 166_H 0.81 0.00
80_Q 135_R 0.81 0.00
6_I 161_A 0.81 0.00
100_M 124_A 0.80 0.00
145_R 113_E 0.79 0.00
155_K 71_G 0.79 0.00
25_A 141_V 0.79 0.00
97_L 142_E 0.79 0.00
123_G 132_P 0.79 0.00
126_L 102_I 0.79 0.00
3_V 104_S 0.79 0.00
15_P 53_C 0.79 0.00
14_S 10_P 0.79 0.00
119_M 134_R 0.79 0.00
30_P 64_F 0.78 0.00
20_N 56_V 0.78 0.00
113_T 140_P 0.77 0.00
97_L 120_P 0.77 0.00
42_R 117_L 0.77 0.00
22_A 112_R 0.77 0.00
54_Y 174_I 0.77 0.00
6_I 61_E 0.77 0.00
35_L 153_V 0.77 0.00
4_A 52_L 0.77 0.00
8_I 46_F 0.77 0.00
143_M 6_E 0.77 0.00
45_P 90_I 0.77 0.00
114_V 21_L 0.76 0.00
133_A 22_G 0.76 0.00
97_L 123_L 0.76 0.00
99_I 160_Y 0.76 0.00
90_W 56_V 0.76 0.00
130_F 16_A 0.76 0.00
47_G 64_F 0.76 0.00
117_Y 111_V 0.75 0.00
92_P 168_P 0.75 0.00
86_K 21_L 0.75 0.00
12_L 50_A 0.75 0.00
16_L 123_L 0.75 0.00
151_R 125_I 0.75 0.00
129_L 147_S 0.75 0.00
102_F 163_R 0.75 0.00
77_I 88_E 0.75 0.00
21_A 170_I 0.75 0.00
35_L 129_L 0.74 0.00
44_P 18_I 0.74 0.00
150_T 24_Q 0.74 0.00
67_P 174_I 0.74 0.00
106_V 115_L 0.74 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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