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OPENSEQ.org

HEM2 - HEM3
UniProt: P0ACB2 - P06983
Length: 637
Sequences: 518
Seq/Len: 0.83
I_Prob: 0.00

HEM2 - Delta-aminolevulinic acid dehydratase
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HEM2
HEM3 - Porphobilinogen deaminase
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HEM3
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
73_I 66_L 1.24 0.00
181_A 208_D 1.12 0.00
148_G 290_L 1.07 0.00
260_R 240_G 1.03 0.00
287_A 298_G 1.02 0.00
255_I 50_D 1.02 0.00
133_L 109_V 0.97 0.00
55_R 85_V 0.96 0.00
54_M 7_R 0.96 0.00
184_F 143_L 0.96 0.00
251_A 82_M 0.93 0.00
32_V 203_I 0.92 0.00
110_V 247_G 0.91 0.00
244_L 219_L 0.91 0.00
231_R 228_V 0.91 0.00
243_C 299_A 0.90 0.00
299_G 69_A 0.89 0.00
235_L 205_C 0.89 0.00
277_A 40_P 0.89 0.00
40_E 105_R 0.88 0.00
221_M 48_I 0.88 0.00
83_H 25_D 0.88 0.00
251_A 247_G 0.86 0.00
92_A 158_K 0.86 0.00
279_I 10_T 0.85 0.00
31_L 123_S 0.85 0.00
78_T 261_A 0.84 0.00
124_Y 154_T 0.84 0.00
182_A 95_L 0.84 0.00
103_S 152_V 0.84 0.00
39_E 18_W 0.83 0.00
20_M 88_E 0.83 0.00
295_L 289_S 0.83 0.00
155_A 8_I 0.83 0.00
39_E 63_V 0.83 0.00
184_F 223_E 0.82 0.00
199_S 125_V 0.82 0.00
163_A 158_K 0.82 0.00
319_E 29_A 0.82 0.00
231_R 66_L 0.82 0.00
28_L 145_I 0.81 0.00
193_S 250_A 0.81 0.00
54_M 116_L 0.81 0.00
22_E 53_L 0.81 0.00
105_I 66_L 0.80 0.00
103_S 53_L 0.80 0.00
297_S 38_L 0.80 0.00
316_D 236_T 0.80 0.00
104_R 261_A 0.79 0.00
39_E 174_L 0.78 0.00
147_L 67_E 0.78 0.00
57_P 103_D 0.78 0.00
193_S 128_S 0.78 0.00
294_V 247_G 0.77 0.00
187_T 109_V 0.77 0.00
181_A 203_I 0.77 0.00
143_T 24_K 0.77 0.00
104_R 289_S 0.76 0.00
200_F 107_A 0.76 0.00
50_M 162_G 0.76 0.00
280_K 128_S 0.76 0.00
53_V 200_A 0.76 0.00
221_M 50_D 0.76 0.00
85_T 109_V 0.76 0.00
160_D 157_S 0.76 0.00
320_K 247_G 0.75 0.00
237_E 183_I 0.75 0.00
226_R 156_L 0.75 0.00
193_S 137_A 0.74 0.00
234_L 152_V 0.74 0.00
106_C 265_A 0.74 0.00
187_T 156_L 0.73 0.00
32_V 261_A 0.73 0.00
133_L 103_D 0.73 0.00
47_V 299_A 0.73 0.00
147_L 240_G 0.73 0.00
57_P 64_K 0.73 0.00
194_T 164_Y 0.73 0.00
147_L 130_L 0.73 0.00
166_A 153_G 0.72 0.00
152_V 187_L 0.72 0.00
46_A 137_A 0.72 0.00
44_Y 48_I 0.72 0.00
196_F 70_L 0.72 0.00
111_P 67_E 0.72 0.00
300_S 178_G 0.71 0.00
50_M 224_T 0.71 0.00
193_S 296_N 0.71 0.00
300_S 55_K 0.71 0.00
280_K 148_L 0.71 0.00
22_E 47_V 0.71 0.00
215_D 9_A 0.71 0.00
56_I 244_V 0.71 0.00
148_G 203_I 0.71 0.00
40_E 103_D 0.71 0.00
191_S 128_S 0.71 0.00
291_E 20_A 0.71 0.00
31_L 234_M 0.71 0.00
291_E 137_A 0.71 0.00
243_C 205_C 0.71 0.00
142_A 125_V 0.70 0.00
258_E 256_E 0.70 0.00
57_P 171_V 0.70 0.00
255_I 190_E 0.70 0.00
114_I 156_L 0.69 0.00
307_D 304_A 0.69 0.00
31_L 259_L 0.69 0.00
55_R 202_G 0.69 0.00
78_T 7_R 0.69 0.00
117_S 174_L 0.69 0.00
159_A 52_P 0.69 0.00
177_Q 137_A 0.69 0.00
244_L 56_V 0.69 0.00
298_L 56_V 0.69 0.00
287_A 245_P 0.68 0.00
302_K 78_A 0.68 0.00
285_A 166_A 0.68 0.00
292_K 77_I 0.68 0.00
83_H 38_L 0.68 0.00
199_S 192_S 0.68 0.00
299_G 25_D 0.68 0.00
162_I 37_E 0.68 0.00
163_A 234_M 0.68 0.00
114_I 202_G 0.68 0.00
143_T 8_I 0.68 0.00
227_R 261_A 0.68 0.00
154_A 205_C 0.68 0.00
251_A 8_I 0.68 0.00
217_K 148_L 0.67 0.00
124_Y 21_H 0.67 0.00
211_A 17_L 0.67 0.00
93_W 24_K 0.67 0.00
291_E 212_T 0.67 0.00
119_T 18_W 0.67 0.00
38_E 63_V 0.67 0.00
264_E 73_N 0.67 0.00
35_I 28_M 0.67 0.00
209_G 20_A 0.67 0.00
166_A 67_E 0.67 0.00
293_V 296_N 0.67 0.00
63_R 290_L 0.67 0.00
265_L 163_E 0.67 0.00
73_I 27_L 0.66 0.00
277_A 110_S 0.66 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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