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OPENSEQ.org
HEM3 - Porphobilinogen deaminase
UniProt: P06983 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10429
Length: 313 (304)
Sequences: 1707
Seq/Len: 5.62
HEM3
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
157_S 161_N 4.624 1.00
9_A 75_A 4.038 1.00
220_N 225_A 3.956 1.00
100_E 221_H 3.555 1.00
7_R 39_V 3.343 1.00
206_R 209_D 3.061 1.00
24_K 28_M 2.951 1.00
102_E 175_K 2.935 1.00
12_Q 40_P 2.749 1.00
274_G 290_L 2.717 1.00
171_V 186_A 2.588 1.00
265_A 269_S 2.549 1.00
12_Q 42_V 2.509 1.00
200_A 228_V 2.496 1.00
237_R 292_E 2.449 1.00
124_I 146_R 2.291 1.00
263_V 299_A 2.255 1.00
160_D 182_R 2.251 1.00
26_K 29_A 2.201 1.00
148_L 167_I 2.153 1.00
221_H 224_T 2.123 1.00
68_V 72_E 2.013 1.00
256_E 277_R 1.984 1.00
274_G 293_E 1.934 1.00
82_M 197_G 1.934 1.00
22_Y 26_K 1.933 1.00
260_R 275_E 1.917 1.00
133_Q 137_A 1.911 1.00
8_I 24_K 1.904 1.00
276_R 293_E 1.889 1.00
94_G 207_L 1.856 1.00
300_R 304_A 1.855 1.00
99_C 201_V 1.847 1.00
146_R 164_Y 1.846 1.00
67_E 204_E 1.838 1.00
14_P 153_G 1.827 1.00
152_V 177_L 1.809 1.00
276_R 290_L 1.791 1.00
21_H 25_D 1.787 1.00
153_G 179_L 1.785 1.00
234_M 261_A 1.781 1.00
92_G 207_L 1.775 1.00
115_S 118_A 1.76 1.00
114_D 118_A 1.735 1.00
124_I 144_I 1.678 1.00
278_G 286_M 1.674 1.00
251_E 258_W 1.653 1.00
222_H 226_L 1.639 0.99
258_W 277_R 1.624 0.99
188_P 191_I 1.604 0.99
94_G 213_R 1.601 0.99
98_I 200_A 1.591 0.99
71_L 93_L 1.574 0.99
210_S 214_E 1.566 0.99
41_M 66_L 1.556 0.99
225_A 229_T 1.552 0.99
270_Q 301_E 1.547 0.99
105_R 186_A 1.54 0.99
10_T 38_L 1.533 0.99
258_W 275_E 1.527 0.99
227_R 252_L 1.525 0.99
125_V 166_A 1.523 0.99
48_I 51_T 1.501 0.99
20_A 38_L 1.491 0.99
117_D 185_A 1.485 0.99
293_E 297_N 1.482 0.99
237_R 288_I 1.481 0.99
105_R 171_V 1.478 0.99
21_H 24_K 1.476 0.99
97_T 220_N 1.474 0.99
42_V 47_V 1.473 0.99
75_A 78_A 1.467 0.99
282_D 285_Q 1.462 0.99
96_V 205_C 1.46 0.99
69_A 74_R 1.419 0.98
292_E 296_N 1.415 0.98
274_G 297_N 1.414 0.98
24_K 36_V 1.397 0.98
30_S 218_A 1.396 0.98
139_R 191_I 1.378 0.98
17_L 40_P 1.362 0.97
187_L 192_S 1.358 0.97
7_R 37_E 1.355 0.97
25_D 28_M 1.331 0.97
175_K 180_E 1.329 0.97
109_V 174_L 1.327 0.97
5_V 35_V 1.324 0.97
28_M 35_V 1.32 0.97
229_T 284_E 1.315 0.97
26_K 30_S 1.304 0.96
103_D 171_V 1.297 0.96
137_A 145_I 1.294 0.96
230_A 259_L 1.287 0.96
289_S 293_E 1.252 0.95
214_E 217_A 1.246 0.95
264_G 271_I 1.245 0.95
117_D 191_I 1.245 0.95
223_E 280_P 1.242 0.95
287_G 291_A 1.24 0.95
96_V 213_R 1.235 0.95
119_L 123_S 1.234 0.95
146_R 163_E 1.231 0.95
196_V 248_S 1.221 0.94
109_V 156_L 1.204 0.94
5_V 37_E 1.201 0.94
283_A 287_G 1.192 0.93
18_W 22_Y 1.184 0.93
205_C 213_R 1.176 0.93
20_A 24_K 1.17 0.93
152_V 179_L 1.169 0.92
49_L 153_G 1.165 0.92
134_C 264_G 1.164 0.92
98_I 228_V 1.16 0.92
159_L 167_I 1.155 0.92
133_Q 147_S 1.154 0.92
56_V 63_V 1.152 0.92
31_H 218_A 1.151 0.92
237_R 295_L 1.147 0.92
123_S 140_R 1.139 0.91
251_E 260_R 1.134 0.91
247_G 262_L 1.126 0.91
59_K 65_E 1.122 0.90
276_R 289_S 1.119 0.90
70_L 73_N 1.109 0.90
94_G 205_C 1.104 0.89
25_D 29_A 1.103 0.89
226_L 280_P 1.098 0.89
8_I 36_V 1.097 0.89
205_C 216_L 1.09 0.89
110_S 184_R 1.089 0.88
209_D 212_T 1.081 0.88
82_M 202_G 1.078 0.88
276_R 286_M 1.077 0.88
95_L 202_G 1.072 0.87
153_G 157_S 1.068 0.87
107_A 171_V 1.065 0.87
234_M 290_L 1.059 0.87
121_A 142_D 1.059 0.87
41_M 69_A 1.054 0.86
200_A 224_T 1.047 0.86
294_L 299_A 1.045 0.86
185_A 191_I 1.043 0.85
69_A 75_A 1.04 0.85
288_I 292_E 1.025 0.84
285_Q 289_S 1.021 0.84
82_M 228_V 1.015 0.83
17_L 21_H 1.013 0.83
138_E 271_I 1.01 0.83
301_E 304_A 1.01 0.83
7_R 73_N 1.009 0.83
123_S 142_D 1.003 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gtkA111000.006Contact Map0.779
3ecrA20.99681000.031Contact Map0.847
4htgA10.97441000.036Contact Map0.776
3un6A10.827596.50.939Contact Map0.543
1xs5A10.655960.942Contact Map0.616
3tqwA20.661395.90.942Contact Map0.668
3up9A10.664595.90.942Contact Map0.647
3ir1A60.677395.70.943Contact Map0.761
3k2dA20.645495.60.943Contact Map0.639
3l6gA10.72295.40.944Contact Map0.555
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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