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Instructions
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Coupling matrix for [S:0127] and [Y:0249]
- A F I L V M W Y D E K R H N Q S T G P C
A -0.1 1.7 0 -0.2 -0.1 -0.2 -0.4 0.5 0 0 -0.1 -0.2 -0.1 0 -0.1 -0.1 -0.1 0 0 0
F 0 0.9 0 -0.1 0 0.5 -0.2 -0.7 0 0 0 -0.1 0 0 0 0 0 0 0 0
I 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
L 0.5 -0.4 0 0 0 -0.1 -0.1 0.5 0 0 0 -0.1 0 0 0 0 0 0 0 0
V 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
M 0 -0.2 0 0 0 0 0.5 -0.2 0 0 0 0 0 0 0 0 0 0 0 0
W 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
Y 0 -0.3 0 0 0 0 0.3 0.2 0 0 0 0 0 0 0 0 0 0 0 0
D 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
E 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
K 0 0.2 0 -0.1 -0.1 -0.1 1.1 0.4 0 0 -0.1 -0.2 -0.1 0 -0.1 0 -0.1 0 0 0
R -0.2 -0.2 -0.1 0.6 0.2 0.1 -0.6 0.1 -0.1 -0.1 0.2 1 0 -0.1 0.5 0.2 0.1 -0.1 -0.1 -0.1
H 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
N 0 -0.2 0 -0.1 0 0 -0.1 0.2 0 0 0 0 0 0 0 0 0 0 0 0
Q 0 0.2 0 0 0 0 0 -0.2 0 0 0 0 0 0 0 0 0 0 0 0
S -0.2 0.3 -0.1 0.3 0.2 0.1 0 0.6 -0.1 -0.1 -0.1 0 0.4 -0.1 -0.1 -0.2 0.3 -0.1 -0.1 -0.1
T 0 0.2 0 0 0 0 -0.1 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
G 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
P 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0
C 0 -0.1 0 0 0 0 0 -0.1 0 0 0 0 0 0 0 0 0 0 0 0

Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0127 0.9 0.1 -0.6 0.2 -0.6 -0.2 -0.6 0.1 -0.6 -0.6 1.1 2.2 -0.6 -0.4 -0.2 2 -0.1 -0.6 -0.6 -0.6
0249 -0.1 0.8 -0.3 0.4 0.1 0.1 0.3 1.1 -0.3 -0.3 -0.2 0.3 0.1 -0.3 -0.1 -0.1 0.1 -0.3 -0.3 -0.3
Select residue pair below:
i_j Score Prob
0249_0257 3.319 1.00
0131_0270 3.157 1.00
0242_0262 2.947 1.00
0231_0242 2.805 1.00
0194_0216 2.667 1.00
0159_0179 2.467 0.99
0198_0203 2.433 0.99
0088_0260 2.426 0.99
0161_0179 2.242 0.99
0261_0277 2.162 0.98
0087_0120 2.144 0.98
0055_0094 2.129 0.98
0191_0217 2.021 0.97
0263_0275 2.006 0.97
0234_0239 1.922 0.96
0108_0140 1.899 0.95
0116_0132 1.898 0.95
0139_0159 1.782 0.93
0160_0176 1.692 0.90
0094_0121 1.675 0.89
0128_0172 1.659 0.89
0063_0280 1.648 0.88
0052_0285 1.629 0.87
0135_0161 1.618 0.87
0244_0260 1.550 0.84
0098_0101 1.524 0.82
0226_0247 1.521 0.82
0163_0255 1.509 0.81
0114_0134 1.499 0.81
0133_0167 1.496 0.81
0159_0180 1.470 0.79
0123_0210 1.430 0.76
0159_0258 1.427 0.76
0189_0221 1.425 0.76
0052_0097 1.399 0.74
0038_0042 1.397 0.74
0106_0179 1.395 0.74
0214_0244 1.366 0.71
0158_0180 1.361 0.71
0139_0179 1.340 0.69
0251_0257 1.277 0.64
0204_0271 1.276 0.64
0241_0262 1.275 0.64
0263_0277 1.273 0.64
0111_0137 1.262 0.63
0063_0278 1.254 0.62
0150_0186 1.248 0.61
0089_0103 1.236 0.60
0086_0119 1.235 0.60
0052_0231 1.227 0.59
0258_0280 1.221 0.59
0246_0260 1.210 0.58
0069_0271 1.204 0.57
0094_0250 1.203 0.57
0067_0108 1.197 0.57
0135_0163 1.191 0.56
0246_0284 1.191 0.56
0061_0258 1.189 0.56
0065_0276 1.186 0.56
0198_0268 1.185 0.55
0233_0242 1.184 0.55
0209_0251 1.182 0.55
0096_0107 1.180 0.55
0055_0151 1.179 0.55
0151_0189 1.170 0.54
0160_0178 1.166 0.54
0109_0170 1.159 0.53
0113_0281 1.159 0.53
0035_0111 1.140 0.51
0091_0152 1.139 0.51
0138_0160 1.137 0.51
0210_0238 1.137 0.51
0161_0208 1.136 0.51
0114_0153 1.136 0.51
0106_0142 1.135 0.51
0105_0112 1.131 0.50
0059_0094 1.126 0.50
0172_0204 1.121 0.49
0250_0257 1.120 0.49
0216_0275 1.115 0.49
0050_0176 1.112 0.48
0050_0091 1.110 0.48
0120_0160 1.109 0.48
0232_0236 1.095 0.47
0230_0243 1.095 0.47
0039_0044 1.095 0.47
0086_0137 1.093 0.47
0112_0140 1.083 0.46
0163_0175 1.080 0.45
0246_0258 1.079 0.45
0117_0278 1.071 0.44
0058_0204 1.069 0.44
0061_0280 1.066 0.44
0127_0249 1.060 0.43
0119_0280 1.057 0.43
0175_0198 1.057 0.43
0041_0048 1.041 0.42
0109_0183 1.041 0.42
0216_0233 1.034 0.41
0086_0130 1.030 0.41
0194_0262 1.029 0.40
0212_0242 1.025 0.40
0138_0251 1.022 0.40
0208_0212 1.020 0.40
0175_0196 1.019 0.40
0119_0137 1.016 0.39
0267_0279 1.012 0.39
0057_0288 1.010 0.39
0134_0167 1.009 0.39
0172_0267 1.008 0.38
0276_0280 1.007 0.38
0236_0239 1.006 0.38
0039_0043 1.005 0.38
0267_0280 1.000 0.38
0052_0251 0.998 0.38
0114_0215 0.997 0.37
0216_0219 0.997 0.37
0128_0204 0.996 0.37
0204_0269 0.992 0.37
0188_0243 0.990 0.37
0036_0044 0.989 0.37
0163_0256 0.985 0.36
0222_0249 0.981 0.36
0184_0261 0.978 0.36
0091_0279 0.976 0.36
0039_0042 0.974 0.35
0045_0053 0.969 0.35
0189_0193 0.967 0.35
0119_0130 0.966 0.35
0096_0099 0.965 0.35
0152_0194 0.965 0.35
0109_0154 0.965 0.35
0230_0245 0.963 0.34
0193_0216 0.961 0.34
0243_0263 0.956 0.34
0065_0280 0.956 0.34
0045_0051 0.956 0.34
0120_0123 0.955 0.34
0037_0041 0.955 0.34
0177_0196 0.955 0.34
0244_0251 0.953 0.34
0035_0038 0.951 0.33
0034_0039 0.948 0.33
0157_0181 0.947 0.33
0163_0198 0.943 0.33
0109_0114 0.941 0.33
0132_0167 0.940 0.32
0130_0177 0.938 0.32
0105_0142 0.936 0.32
0134_0147 0.934 0.32
0118_0174 0.933 0.32
0085_0121 0.932 0.32
0122_0163 0.929 0.32
0267_0271 0.928 0.31
0087_0097 0.927 0.31
0057_0148 0.925 0.31
0177_0198 0.924 0.31
0060_0080 0.922 0.31
0135_0198 0.921 0.31
0093_0253 0.921 0.31
0178_0197 0.921 0.31
0061_0121 0.919 0.31
0135_0176 0.918 0.31
0258_0284 0.918 0.31
0108_0269 0.918 0.31
0132_0285 0.917 0.31
0106_0140 0.917 0.31
0167_0227 0.916 0.30
0056_0137 0.913 0.30
0102_0108 0.912 0.30
0209_0237 0.910 0.30
0096_0109 0.907 0.30
0048_0096 0.906 0.30
0148_0283 0.905 0.30
0214_0236 0.904 0.29
0063_0133 0.903 0.29
0108_0135 0.903 0.29
0042_0289 0.900 0.29
0144_0149 0.899 0.29
0069_0159 0.899 0.29
0112_0267 0.897 0.29
0122_0284 0.897 0.29
0109_0256 0.896 0.29
0183_0215 0.896 0.29
0153_0191 0.893 0.29
0106_0122 0.892 0.29
0122_0135 0.890 0.28
0249_0288 0.890 0.28
0119_0177 0.889 0.28
0108_0245 0.886 0.28
0220_0249 0.885 0.28
0168_0172 0.884 0.28
0129_0250 0.883 0.28
0214_0284 0.880 0.28
0224_0243 0.877 0.27
0056_0111 0.876 0.27
0131_0278 0.874 0.27
0035_0041 0.870 0.27
0259_0281 0.869 0.27
0228_0245 0.868 0.27
0058_0203 0.868 0.27
0093_0110 0.867 0.27
0241_0258 0.866 0.27
0054_0251 0.866 0.27
0099_0183 0.865 0.26
0135_0210 0.865 0.26
0096_0154 0.864 0.26
0111_0138 0.864 0.26
0091_0116 0.864 0.26
0158_0193 0.863 0.26
0158_0189 0.862 0.26
0037_0040 0.861 0.26
0179_0194 0.860 0.26
0042_0109 0.859 0.26
0059_0134 0.859 0.26
0130_0137 0.858 0.26
0127_0242 0.858 0.26
0036_0039 0.858 0.26
0138_0195 0.856 0.26
0091_0249 0.856 0.26
0113_0251 0.855 0.26
0149_0281 0.853 0.26
0111_0154 0.852 0.25
0113_0138 0.852 0.25
0122_0161 0.851 0.25
0196_0208 0.851 0.25
0042_0055 0.850 0.25
0087_0267 0.850 0.25
0133_0278 0.850 0.25
0206_0270 0.849 0.25
0117_0268 0.845 0.25
0038_0053 0.844 0.25
0117_0216 0.843 0.25
0055_0274 0.838 0.24
0168_0185 0.836 0.24
0262_0278 0.836 0.24
0048_0077 0.835 0.24
0233_0241 0.834 0.24
0098_0247 0.834 0.24
0093_0239 0.833 0.24
0069_0175 0.832 0.24
0060_0067 0.831 0.24
0106_0133 0.831 0.24
0051_0065 0.830 0.24
0057_0152 0.830 0.24
0033_0036 0.829 0.24
0059_0160 0.827 0.24
0086_0269 0.826 0.24
0052_0246 0.825 0.24
0247_0256 0.825 0.24
0167_0259 0.824 0.23
0130_0235 0.824 0.23
0050_0118 0.823 0.23
0086_0204 0.823 0.23
0237_0240 0.822 0.23
0038_0289 0.822 0.23
0093_0274 0.819 0.23
0261_0279 0.818 0.23
0102_0106 0.818 0.23
0061_0270 0.817 0.23
0204_0268 0.815 0.23
0040_0044 0.815 0.23
0072_0139 0.815 0.23
0058_0063 0.814 0.23
0193_0217 0.813 0.23
0082_0102 0.812 0.23
0212_0215 0.812 0.23
0212_0259 0.812 0.23
0211_0245 0.812 0.23
0069_0273 0.810 0.23
0039_0093 0.810 0.23
0214_0286 0.810 0.23
0141_0155 0.809 0.22
0055_0251 0.809 0.22
0235_0240 0.809 0.22
0050_0074 0.808 0.22
0249_0254 0.805 0.22
0113_0276 0.805 0.22
0112_0142 0.805 0.22
0214_0229 0.802 0.22
0061_0131 0.802 0.22
0042_0137 0.801 0.22
0089_0131 0.801 0.22
0065_0277 0.800 0.22
0127_0219 0.800 0.22
0167_0195 0.799 0.22
0035_0039 0.797 0.22
0082_0125 0.797 0.22
0217_0237 0.797 0.22
0219_0253 0.796 0.22
0060_0270 0.796 0.22
0040_0048 0.796 0.22
0078_0288 0.795 0.22
0182_0279 0.793 0.21
0229_0257 0.790 0.21
0069_0177 0.788 0.21
0038_0041 0.788 0.21
0068_0260 0.786 0.21
0197_0224 0.786 0.21
0071_0074 0.785 0.21
0041_0045 0.785 0.21
0206_0216 0.784 0.21
0233_0268 0.783 0.21
0216_0244 0.782 0.21
0221_0228 0.781 0.21
0083_0122 0.781 0.21
0176_0213 0.781 0.21
0112_0134 0.779 0.20
0128_0269 0.777 0.20
0111_0122 0.776 0.20
0228_0247 0.774 0.20
0113_0199 0.773 0.20
0201_0212 0.772 0.20
0106_0161 0.771 0.20
0138_0178 0.770 0.20
0175_0208 0.770 0.20
0210_0248 0.769 0.20
0201_0281 0.767 0.20
0034_0044 0.766 0.20
0233_0262 0.765 0.20
0221_0279 0.764 0.20
0050_0117 0.763 0.19
0121_0250 0.763 0.19
0051_0055 0.762 0.19
0083_0245 0.762 0.19
0119_0122 0.759 0.19
0203_0206 0.757 0.19
0140_0267 0.757 0.19
0220_0270 0.756 0.19
0130_0208 0.755 0.19
0055_0250 0.755 0.19
0193_0233 0.754 0.19
0057_0150 0.753 0.19
0100_0191 0.753 0.19
0052_0230 0.752 0.19
0086_0122 0.752 0.19
0221_0244 0.752 0.19
0086_0270 0.752 0.19
0050_0184 0.751 0.19
0139_0260 0.751 0.19
0234_0242 0.751 0.19
0050_0189 0.748 0.19
0163_0170 0.747 0.19
0088_0267 0.747 0.19
0033_0242 0.746 0.18
0052_0110 0.745 0.18
0087_0091 0.745 0.18
0203_0256 0.745 0.18
0248_0269 0.744 0.18
0156_0242 0.743 0.18
0119_0198 0.742 0.18
0183_0187 0.742 0.18
0180_0244 0.740 0.18
0112_0201 0.740 0.18
0207_0248 0.739 0.18
0215_0242 0.739 0.18
0137_0177 0.739 0.18
0177_0208 0.738 0.18
0123_0281 0.738 0.18
0068_0106 0.738 0.18
0229_0248 0.738 0.18
0128_0267 0.737 0.18
0198_0204 0.737 0.18
0094_0137 0.734 0.18
0050_0203 0.734 0.18
0118_0273 0.734 0.18
0056_0135 0.734 0.18
0066_0160 0.733 0.18
0104_0195 0.733 0.18
0042_0053 0.733 0.18
0267_0278 0.733 0.18
0055_0286 0.732 0.18
0170_0224 0.732 0.18
0256_0284 0.731 0.18
0100_0215 0.731 0.18
0070_0078 0.729 0.18
0145_0287 0.728 0.17
0066_0168 0.728 0.17
0060_0240 0.728 0.17
0178_0273 0.727 0.17
0102_0105 0.727 0.17
0183_0273 0.727 0.17
0033_0041 0.726 0.17
0115_0163 0.725 0.17
0058_0286 0.725 0.17
Local Interactions:
i_j Score Prob
0244_0246 2.700 1.00
0261_0263 2.382 0.99
0214_0215 2.033 0.97
0234_0236 1.958 0.96
0112_0114 1.823 0.94
0169_0170 1.818 0.94
0131_0133 1.669 0.89
0149_0150 1.621 0.87
0193_0195 1.603 0.86
0241_0242 1.566 0.84
0115_0117 1.499 0.81
0231_0233 1.330 0.69
0035_0037 1.297 0.66
0204_0206 1.230 0.60
0178_0180 1.228 0.59
0238_0239 1.215 0.58
0239_0240 1.183 0.55
0234_0235 1.160 0.53
0074_0075 1.158 0.53
0039_0041 1.106 0.48
0036_0037 1.089 0.46
0268_0270 1.062 0.44
0207_0209 1.058 0.43
0279_0280 1.026 0.40
0197_0199 0.999 0.38
0107_0109 0.979 0.36
0106_0107 0.967 0.35
0142_0144 0.961 0.34
0076_0077 0.925 0.31
0034_0035 0.917 0.31
0180_0182 0.911 0.30
0253_0254 0.909 0.30
0033_0034 0.891 0.28
0235_0236 0.887 0.28
0035_0036 0.883 0.28
0245_0246 0.876 0.27
0034_0036 0.874 0.27
0040_0041 0.864 0.26
0228_0230 0.863 0.26
0225_0226 0.862 0.26
0051_0053 0.861 0.26
0179_0180 0.856 0.26
0175_0177 0.852 0.25
0142_0143 0.845 0.25
0044_0045 0.798 0.22
0075_0077 0.794 0.21
0104_0106 0.789 0.21
0053_0054 0.778 0.20
0042_0043 0.768 0.20
0083_0085 0.765 0.20
0221_0223 0.761 0.19
0158_0160 0.756 0.19
0139_0141 0.753 0.19
0168_0169 0.752 0.19
0083_0084 0.748 0.19
0230_0231 0.747 0.19
0078_0079 0.740 0.18
0080_0081 0.727 0.17
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: M R T L Q ...

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