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OPENSEQ.org
XDHD - Probable hypoxanthine oxidase XdhD
UniProt: Q46814 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13064
Length: 956 (888)
Sequences: 1259
Seq/Len: 1.42
XDHD
Paralog alert: 0.54 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: XDHA XDHD YAGR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
206_L 290_I 7.307 1.00
226_L 289_L 5.235 1.00
380_E 492_K 4.703 1.00
206_L 287_L 4.627 1.00
382_T 490_T 4.228 1.00
222_K 291_D 3.921 1.00
210_H 213_A 3.889 1.00
495_A 575_L 3.824 1.00
287_L 290_I 3.803 1.00
226_L 282_I 3.801 1.00
279_S 282_I 3.8 1.00
376_D 496_K 3.73 1.00
213_A 294_Y 3.707 1.00
581_I 589_R 3.479 1.00
201_C 230_V 3.38 1.00
376_D 497_K 3.354 1.00
372_F 494_G 3.347 1.00
216_T 293_E 3.225 1.00
276_V 460_A 3.199 1.00
832_K 897_R 3.09 1.00
496_K 500_R 3.074 1.00
505_K 540_D 3.039 1.00
212_H 297_L 3.02 1.00
210_H 296_V 2.767 1.00
677_F 704_C 2.748 1.00
698_A 738_A 2.725 1.00
367_D 370_K 2.717 1.00
507_D 542_Q 2.712 1.00
278_E 466_R 2.703 1.00
511_N 550_I 2.674 1.00
492_K 505_K 2.658 1.00
217_H 293_E 2.641 1.00
406_R 717_D 2.634 1.00
701_V 743_E 2.62 1.00
370_K 374_D 2.605 1.00
214_L 295_E 2.595 1.00
372_F 492_K 2.582 1.00
230_V 278_E 2.52 1.00
501_L 572_L 2.515 1.00
931_I 944_F 2.453 1.00
701_V 910_F 2.351 0.99
588_E 626_R 2.348 0.99
669_I 679_V 2.344 0.99
435_H 715_D 2.342 0.99
500_R 589_R 2.335 0.99
380_E 490_T 2.331 0.99
377_V 495_A 2.32 0.99
220_V 224_E 2.306 0.99
493_L 571_A 2.284 0.99
304_D 488_K 2.236 0.99
229_V 277_A 2.233 0.99
397_I 471_R 2.227 0.99
193_E 469_L 2.21 0.99
209_P 272_V 2.203 0.99
581_I 586_I 2.203 0.99
491_V 571_A 2.169 0.99
216_T 295_E 2.141 0.99
928_A 944_F 2.139 0.99
507_D 544_T 2.111 0.99
408_V 435_H 2.109 0.99
276_V 464_T 2.104 0.99
628_G 816_F 2.087 0.98
377_V 496_K 2.066 0.98
305_E 308_A 2.045 0.98
493_L 575_L 2.039 0.98
226_L 286_A 2.037 0.98
585_E 589_R 2.027 0.98
277_A 283_A 2.015 0.98
535_P 596_Q 2.011 0.98
375_A 502_T 2.009 0.98
212_H 298_K 1.998 0.98
391_C 881_L 1.974 0.98
857_L 892_I 1.95 0.97
377_V 497_K 1.896 0.97
210_H 294_Y 1.873 0.96
230_V 466_R 1.871 0.96
212_H 264_K 1.858 0.96
214_L 264_K 1.856 0.96
408_V 437_I 1.854 0.96
815_N 833_F 1.85 0.96
842_P 900_L 1.848 0.96
633_Q 636_S 1.846 0.96
746_R 750_L 1.844 0.96
370_K 373_A 1.833 0.96
203_I 274_A 1.827 0.96
203_I 468_V 1.822 0.95
671_L 745_L 1.822 0.95
197_T 200_A 1.813 0.95
423_V 434_V 1.806 0.95
941_E 948_K 1.769 0.94
569_T 587_I 1.768 0.94
841_T 902_P 1.757 0.94
377_V 579_L 1.75 0.94
189_P 440_R 1.75 0.94
212_H 299_P 1.743 0.94
375_A 494_G 1.738 0.94
33_S 74_A 1.733 0.94
282_I 286_A 1.719 0.93
392_P 447_S 1.718 0.93
856_T 896_F 1.716 0.93
500_R 535_P 1.714 0.93
205_M 274_A 1.712 0.93
278_E 282_I 1.685 0.92
205_M 470_F 1.677 0.92
213_A 292_V 1.661 0.92
303_I 509_R 1.643 0.91
739_R 743_E 1.637 0.91
221_S 224_E 1.634 0.91
677_F 702_L 1.632 0.91
377_V 575_L 1.628 0.91
676_T 708_D 1.627 0.91
593_H 596_Q 1.622 0.90
273_A 292_V 1.62 0.90
233_I 460_A 1.613 0.90
228_G 286_A 1.612 0.90
274_A 460_A 1.608 0.90
230_V 282_I 1.605 0.90
229_V 283_A 1.604 0.90
215_I 218_L 1.604 0.90
485_H 563_K 1.599 0.90
124_I 146_E 1.585 0.89
460_A 468_V 1.582 0.89
401_R 410_H 1.581 0.89
751_F 761_V 1.573 0.88
214_L 297_L 1.572 0.88
409_I 423_V 1.569 0.88
222_K 225_A 1.566 0.88
429_M 434_V 1.559 0.88
199_D 466_R 1.551 0.88
371_G 503_A 1.549 0.87
819_V 931_I 1.535 0.87
424_A 434_V 1.534 0.87
669_I 742_A 1.515 0.86
270_D 515_Y 1.512 0.86
220_V 290_I 1.509 0.86
498_D 589_R 1.501 0.85
523_P 543_V 1.497 0.85
378_I 492_K 1.495 0.85
232_V 275_V 1.453 0.82
731_T 843_V 1.447 0.82
575_L 586_I 1.447 0.82
381_R 574_E 1.443 0.82
760_P 763_D 1.443 0.82
307_M 546_Y 1.439 0.82
588_E 629_R 1.437 0.81
848_A 900_L 1.434 0.81
820_A 831_D 1.433 0.81
223_A 290_I 1.433 0.81
584_L 629_R 1.43 0.81
235_H 262_G 1.427 0.81
207_R 476_E 1.423 0.81
697_L 731_T 1.422 0.81
193_E 471_R 1.42 0.80
302_S 305_E 1.415 0.80
400_T 461_T 1.411 0.80
695_T 711_V 1.408 0.80
308_A 311_A 1.401 0.79
632_I 834_Y 1.399 0.79
493_L 501_L 1.399 0.79
738_A 742_A 1.397 0.79
629_R 635_S 1.396 0.79
412_S 416_P 1.394 0.79
368_M 372_F 1.393 0.79
646_I 820_A 1.391 0.79
390_Q 447_S 1.384 0.78
414_Q 444_G 1.373 0.77
231_H 463_V 1.372 0.77
627_Q 899_V 1.368 0.77
573_A 929_T 1.368 0.77
842_P 848_A 1.345 0.75
817_A 830_L 1.34 0.75
213_A 297_L 1.336 0.74
869_I 878_T 1.33 0.74
753_G 764_V 1.328 0.74
736_N 739_R 1.327 0.74
275_V 287_L 1.324 0.74
512_T 519_S 1.324 0.74
176_Y 706_P 1.321 0.73
758_G 763_D 1.319 0.73
858_R 887_P 1.319 0.73
384_N 488_K 1.313 0.73
200_A 399_F 1.313 0.73
225_A 291_D 1.311 0.72
236_L 263_K 1.31 0.72
828_I 864_M 1.307 0.72
698_A 742_A 1.305 0.72
486_V 511_N 1.304 0.72
509_R 544_T 1.302 0.72
585_E 588_E 1.299 0.72
679_V 698_A 1.298 0.71
834_Y 897_R 1.282 0.70
701_V 742_A 1.279 0.70
752_H 784_I 1.276 0.70
266_R 270_D 1.274 0.69
215_I 294_Y 1.273 0.69
668_M 800_T 1.273 0.69
415_V 726_Y 1.272 0.69
830_L 927_I 1.272 0.69
206_L 292_V 1.269 0.69
192_V 397_I 1.268 0.69
744_N 799_G 1.264 0.69
206_L 273_A 1.264 0.69
205_M 271_R 1.262 0.68
233_I 459_W 1.258 0.68
229_V 286_A 1.257 0.68
494_G 502_T 1.25 0.67
110_T 114_D 1.244 0.67
682_G 719_A 1.241 0.66
264_K 316_D 1.24 0.66
364_H 540_D 1.24 0.66
383_Y 574_E 1.239 0.66
859_A 923_A 1.237 0.66
286_A 289_L 1.236 0.66
572_L 586_I 1.235 0.66
512_T 553_N 1.233 0.66
631_M 836_L 1.227 0.65
759_E 763_D 1.226 0.65
861_G 887_P 1.225 0.65
705_P 708_D 1.224 0.65
750_L 766_L 1.224 0.65
396_H 477_E 1.222 0.65
128_L 145_I 1.22 0.65
379_I 578_Q 1.22 0.65
368_M 503_A 1.216 0.64
222_K 289_L 1.211 0.64
238_C 459_W 1.209 0.63
487_A 510_A 1.209 0.63
571_A 575_L 1.209 0.63
672_E 678_I 1.209 0.63
696_K 845_P 1.208 0.63
224_E 231_H 1.206 0.63
631_M 897_R 1.205 0.63
723_K 726_Y 1.197 0.62
849_L 898_A 1.197 0.62
632_I 816_F 1.195 0.62
647_G 821_V 1.195 0.62
179_T 692_T 1.194 0.62
225_A 232_V 1.194 0.62
183_K 691_D 1.194 0.62
381_R 578_Q 1.192 0.62
412_S 444_G 1.19 0.62
920_V 924_A 1.189 0.62
671_L 781_F 1.185 0.61
566_F 928_A 1.185 0.61
501_L 538_N 1.184 0.61
947_E 951_T 1.179 0.61
574_E 940_R 1.179 0.61
821_V 828_I 1.177 0.60
214_L 263_K 1.176 0.60
197_T 401_R 1.174 0.60
667_C 738_A 1.173 0.60
400_T 409_I 1.169 0.60
383_Y 940_R 1.168 0.60
192_V 471_R 1.165 0.59
821_V 826_G 1.163 0.59
830_L 833_F 1.161 0.59
6_T 70_D 1.155 0.58
273_A 290_I 1.153 0.58
196_V 200_A 1.153 0.58
828_I 949_I 1.151 0.58
701_V 739_R 1.15 0.58
750_L 764_V 1.15 0.58
400_T 457_C 1.15 0.58
593_H 622_E 1.147 0.57
309_E 312_P 1.144 0.57
839_C 852_I 1.143 0.57
376_D 498_D 1.139 0.57
400_T 468_V 1.139 0.57
229_V 232_V 1.137 0.56
50_I 107_L 1.137 0.56
383_Y 571_A 1.134 0.56
671_L 749_I 1.133 0.56
401_R 408_V 1.13 0.56
379_I 495_A 1.129 0.56
503_A 538_N 1.127 0.55
407_L 429_M 1.127 0.55
371_G 538_N 1.126 0.55
582_D 586_I 1.126 0.55
556_Y 858_R 1.125 0.55
949_I 952_A 1.124 0.55
449_Q 726_Y 1.123 0.55
384_N 941_E 1.123 0.55
374_D 496_K 1.123 0.55
7_L 29_M 1.122 0.55
377_V 586_I 1.118 0.55
204_K 283_A 1.117 0.54
220_V 232_V 1.111 0.54
356_N 366_G 1.111 0.54
646_I 818_E 1.11 0.54
217_H 291_D 1.108 0.54
362_H 542_Q 1.107 0.53
411_A 419_L 1.106 0.53
374_D 502_T 1.106 0.53
628_G 814_A 1.104 0.53
683_G 690_L 1.103 0.53
475_E 879_R 1.102 0.53
591_R 622_E 1.101 0.53
683_G 730_G 1.096 0.52
852_I 856_T 1.096 0.52
369_D 505_K 1.096 0.52
652_I 814_A 1.095 0.52
741_A 801_G 1.094 0.52
307_M 357_I 1.093 0.52
676_T 710_H 1.092 0.52
300_V 312_P 1.091 0.52
286_A 290_I 1.091 0.52
382_T 488_K 1.086 0.51
203_I 470_F 1.085 0.51
315_H 515_Y 1.082 0.51
628_G 836_L 1.081 0.51
264_K 297_L 1.08 0.51
424_A 501_L 1.079 0.51
683_G 719_A 1.078 0.50
299_P 572_L 1.075 0.50
944_F 949_I 1.075 0.50
391_C 886_A 1.075 0.50
219_D 291_D 1.072 0.50
332_D 356_N 1.07 0.50
33_S 75_E 1.065 0.49
454_E 559_Y 1.064 0.49
377_V 581_I 1.063 0.49
208_S 213_A 1.063 0.49
534_Y 569_T 1.061 0.49
173_G 845_P 1.057 0.48
493_L 504_V 1.055 0.48
592_V 596_Q 1.053 0.48
509_R 546_Y 1.05 0.48
693_V 847_L 1.05 0.48
307_M 509_R 1.046 0.47
832_K 895_D 1.046 0.47
267_H 271_R 1.044 0.47
780_S 783_D 1.041 0.47
703_H 766_L 1.04 0.47
495_A 571_A 1.039 0.47
412_S 419_L 1.038 0.46
360_S 542_Q 1.038 0.46
679_V 709_V 1.038 0.46
372_F 378_I 1.037 0.46
83_L 87_Q 1.035 0.46
392_P 477_E 1.034 0.46
266_R 514_P 1.033 0.46
302_S 546_Y 1.033 0.46
296_V 299_P 1.032 0.46
226_L 232_V 1.031 0.46
689_G 847_L 1.029 0.45
230_V 233_I 1.029 0.45
276_V 468_V 1.028 0.45
390_Q 483_S 1.028 0.45
715_D 727_A 1.028 0.45
464_T 468_V 1.027 0.45
372_F 503_A 1.02 0.45
19_G 64_A 1.019 0.44
277_A 286_A 1.019 0.44
184_M 191_Y 1.019 0.44
631_M 899_V 1.017 0.44
686_I 713_S 1.017 0.44
207_R 271_R 1.016 0.44
944_F 948_K 1.015 0.44
376_D 500_R 1.014 0.44
204_K 284_L 1.013 0.44
495_A 501_L 1.011 0.44
377_V 578_Q 1.005 0.43
484_R 563_K 1.005 0.43
435_H 717_D 1.003 0.43
817_A 833_F 1.003 0.43
817_A 927_I 1 0.43
563_K 837_L 1 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vlbA10.91841000.2Contact Map0.747
1dgjA10.91841000.201Contact Map0.707
3uncA20.911000.207Contact Map0.76
3zyvA40.90691000.215Contact Map0.686
1rm6A20.77091000.353Contact Map0.782
1ffvB20.80021000.361Contact Map0.764
1t3qB20.78351000.361Contact Map0.789
1n62B20.80331000.362Contact Map0.79
2w3sB40.76671000.371Contact Map0.735
3nvzC20.73431000.384Contact Map0.748
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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