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RHMR - Uncharacterized HTH-type transcriptional regulator RhmR
UniProt: P77732 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14086
Length: 260 (248)
Sequences: 5264
Seq/Len: 21.23
RHMR
Paralog alert: 0.70 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ALLR ICLR KDGR MHPR RHMR YAGI YIAJ YJHI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
10_L 13_A 3.287 1.00
89_R 241_C 3.046 1.00
104_G 140_I 2.57 1.00
14_I 54_F 2.518 1.00
99_L 225_Q 2.508 1.00
11_T 52_Q 2.434 1.00
154_Q 177_H 2.42 1.00
96_T 237_K 2.418 1.00
18_N 68_R 2.394 1.00
142_K 194_E 2.365 1.00
182_R 186_Q 2.353 1.00
110_S 132_S 2.344 1.00
20_I 55_L 2.338 1.00
87_R 115_L 2.188 1.00
204_A 238_A 2.12 1.00
106_I 135_L 2.039 1.00
191_D 201_C 2.023 1.00
142_K 179_E 2.014 1.00
15_D 52_Q 2.011 1.00
16_I 31_I 1.986 1.00
192_N 200_R 1.935 1.00
230_Y 233_Y 1.922 1.00
46_L 55_L 1.92 1.00
19_L 35_L 1.882 1.00
166_T 169_T 1.841 1.00
200_R 223_R 1.834 1.00
92_Q 96_T 1.811 1.00
148_Q 152_V 1.776 1.00
92_Q 244_D 1.759 1.00
19_L 31_I 1.757 1.00
31_I 42_A 1.755 1.00
94_M 101_C 1.734 1.00
89_R 244_D 1.71 1.00
18_N 52_Q 1.704 1.00
147_W 207_F 1.686 1.00
221_G 226_I 1.65 1.00
219_V 234_L 1.648 1.00
111_A 135_L 1.642 1.00
26_C 34_T 1.625 1.00
91_T 117_V 1.617 1.00
235_A 239_I 1.607 1.00
118_E 124_S 1.591 1.00
89_R 248_L 1.587 1.00
27_S 30_T 1.558 1.00
18_N 54_F 1.552 1.00
20_I 26_C 1.551 1.00
204_A 242_A 1.54 1.00
50_R 55_L 1.536 1.00
153_Q 177_H 1.528 1.00
90_L 101_C 1.498 1.00
193_G 223_R 1.486 1.00
86_A 245_I 1.468 1.00
56_S 64_C 1.468 1.00
172_H 175_Q 1.436 1.00
136_Y 169_T 1.433 1.00
246_S 251_W 1.424 1.00
107_D 132_S 1.422 1.00
147_W 205_P 1.42 1.00
193_G 198_D 1.413 1.00
83_R 115_L 1.403 0.99
28_A 43_Y 1.38 0.99
179_E 182_R 1.374 0.99
239_I 243_R 1.371 0.99
149_P 152_V 1.37 0.99
137_R 169_T 1.361 0.99
111_A 144_L 1.335 0.99
103_L 215_A 1.322 0.99
14_I 52_Q 1.318 0.99
207_F 213_L 1.317 0.99
46_L 63_F 1.316 0.99
204_A 239_I 1.312 0.99
93_L 241_C 1.308 0.99
43_Y 47_N 1.303 0.99
180_L 183_I 1.303 0.99
146_A 183_I 1.298 0.99
150_A 181_A 1.293 0.99
109_G 159_G 1.279 0.99
106_I 109_G 1.279 0.99
90_L 103_L 1.274 0.99
183_I 186_Q 1.273 0.99
173_P 177_H 1.271 0.99
188_W 235_A 1.265 0.99
38_P 41_T 1.261 0.99
90_L 217_I 1.258 0.99
89_R 92_Q 1.256 0.99
103_L 206_V 1.256 0.99
97_T 237_K 1.251 0.99
104_G 111_A 1.25 0.99
207_F 246_S 1.248 0.99
145_L 176_L 1.246 0.98
86_A 103_L 1.244 0.98
183_I 189_S 1.242 0.98
31_I 46_L 1.242 0.98
19_L 26_C 1.241 0.98
94_M 117_V 1.237 0.98
138_S 141_G 1.234 0.98
242_A 246_S 1.225 0.98
240_A 244_D 1.22 0.98
32_I 42_A 1.219 0.98
222_T 225_Q 1.214 0.98
37_I 42_A 1.212 0.98
68_R 71_E 1.195 0.98
19_L 34_T 1.193 0.98
204_A 235_A 1.193 0.98
37_I 41_T 1.183 0.98
154_Q 173_P 1.178 0.98
153_Q 184_R 1.164 0.97
205_P 213_L 1.158 0.97
8_P 12_R 1.155 0.97
97_T 219_V 1.148 0.97
168_T 193_G 1.146 0.97
208_N 212_E 1.143 0.97
20_I 25_P 1.141 0.97
69_L 76_A 1.136 0.97
170_I 179_E 1.129 0.97
93_L 237_K 1.118 0.96
87_R 91_T 1.114 0.96
139_G 203_A 1.111 0.96
16_I 35_L 1.098 0.96
179_E 183_I 1.087 0.96
193_G 197_A 1.085 0.96
97_T 234_L 1.082 0.96
201_C 218_S 1.075 0.95
203_A 218_S 1.074 0.95
164_Q 171_T 1.06 0.95
29_A 33_D 1.059 0.95
150_A 184_R 1.058 0.95
96_T 240_A 1.056 0.95
137_R 165_A 1.053 0.95
150_A 177_H 1.052 0.95
217_I 245_I 1.048 0.94
202_V 235_A 1.039 0.94
158_E 173_P 1.038 0.94
50_R 57_L 1.029 0.94
29_A 39_K 1.025 0.93
17_L 69_L 1.023 0.93
147_W 213_L 1.021 0.93
105_I 215_A 1.019 0.93
112_Y 132_S 1.013 0.93
144_L 215_A 1.013 0.93
154_Q 158_E 1.005 0.93
201_C 220_V 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2g7uA40.96921000.079Contact Map0.803
3mq0A20.98081000.08Contact Map0.739
2ia2A40.97311000.082Contact Map0.845
1mkmA20.95381000.092Contact Map0.885
3r4kA40.97311000.095Contact Map0.788
2xrnA20.91921000.118Contact Map0.757
2o0yA40.951000.14Contact Map0.772
1ysqA10.72311000.378Contact Map0.818
1tf1A40.76151000.383Contact Map0.87
3obfA20.67691000.392Contact Map0.717
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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