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OPENSEQ.org
YFEW - UPF0214 protein YfeW
UniProt: P77619 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14164
Length: 434 (395)
Sequences: 1455
Seq/Len: 3.68
YFEW
Paralog alert: 0.31 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: AMPC AMPH YFEW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
119_E 230_S 4.66 1.00
221_Q 229_E 4.248 1.00
96_T 255_A 4.19 1.00
240_T 302_S 4.116 1.00
65_D 386_H 4.048 1.00
115_K 226_Y 3.833 1.00
125_D 152_S 3.831 1.00
228_E 233_R 3.385 1.00
226_Y 230_S 3.224 1.00
123_H 126_D 3.175 1.00
70_Y 74_W 3.169 1.00
126_D 130_K 2.85 1.00
312_Q 315_L 2.816 1.00
118_S 330_T 2.721 1.00
134_G 217_S 2.709 1.00
219_T 226_Y 2.659 1.00
118_S 327_N 2.615 1.00
239_H 253_Q 2.614 1.00
150_R 153_D 2.587 1.00
100_L 302_S 2.509 1.00
159_G 207_D 2.464 1.00
215_V 226_Y 2.448 1.00
73_A 94_T 2.382 1.00
319_G 324_Q 2.379 1.00
92_A 98_Y 2.36 1.00
48_S 52_D 2.317 1.00
77_A 90_V 2.304 1.00
213_F 217_S 2.243 1.00
237_L 240_T 2.204 1.00
328_A 332_K 2.202 1.00
59_N 92_A 2.124 1.00
113_L 211_L 2.105 1.00
112_A 226_Y 2.093 1.00
101_A 375_T 2.082 1.00
309_V 321_G 2.071 1.00
365_S 385_N 2.06 1.00
117_M 122_L 2.052 1.00
59_N 98_Y 2.035 1.00
237_L 306_D 2.033 1.00
44_D 72_K 2.031 1.00
327_N 330_T 2.023 1.00
31_E 37_V 1.976 1.00
59_N 73_A 1.878 1.00
333_M 336_T 1.832 0.99
334_F 345_G 1.808 0.99
30_P 33_A 1.799 0.99
94_T 305_G 1.756 0.99
61_L 68_I 1.748 0.99
369_Y 381_I 1.713 0.99
223_L 227_V 1.704 0.99
71_R 305_G 1.695 0.99
163_A 297_H 1.678 0.99
115_K 230_S 1.67 0.99
222_P 225_R 1.661 0.99
113_L 122_L 1.66 0.99
126_D 131_Y 1.659 0.99
349_R 370_G 1.659 0.99
311_M 381_I 1.656 0.99
143_I 196_Q 1.656 0.99
204_S 207_D 1.646 0.99
122_L 214_I 1.636 0.99
77_A 96_T 1.602 0.98
115_K 325_L 1.599 0.98
113_L 215_V 1.584 0.98
111_F 310_L 1.583 0.98
63_I 308_A 1.569 0.98
93_T 96_T 1.568 0.98
227_V 232_Y 1.566 0.98
115_K 119_E 1.56 0.98
225_R 229_E 1.548 0.98
47_I 60_L 1.518 0.97
110_N 347_G 1.516 0.97
205_D 297_H 1.49 0.97
314_M 369_Y 1.488 0.97
319_G 322_D 1.483 0.97
135_F 149_L 1.481 0.97
317_G 332_K 1.479 0.97
71_R 94_T 1.476 0.97
304_T 392_L 1.464 0.97
134_G 186_E 1.46 0.96
123_H 131_Y 1.459 0.96
219_T 222_P 1.452 0.96
326_F 331_V 1.442 0.96
221_Q 226_Y 1.421 0.96
44_D 70_Y 1.418 0.96
111_F 326_F 1.416 0.96
63_I 388_T 1.412 0.95
110_N 208_Y 1.408 0.95
103_N 307_I 1.403 0.95
380_V 389_I 1.397 0.95
209_M 297_H 1.391 0.95
221_Q 230_S 1.391 0.95
213_F 216_E 1.384 0.95
127_R 130_K 1.379 0.95
295_S 298_A 1.373 0.94
212_G 223_L 1.373 0.94
313_T 325_L 1.363 0.94
245_L 250_K 1.351 0.94
237_L 310_L 1.349 0.94
92_A 96_T 1.346 0.94
309_V 320_Y 1.341 0.94
112_A 215_V 1.338 0.93
122_L 218_V 1.337 0.93
315_L 388_T 1.334 0.93
106_M 379_T 1.324 0.93
51_V 74_W 1.324 0.93
61_L 390_V 1.314 0.93
223_L 296_G 1.311 0.93
104_T 108_A 1.292 0.92
61_L 308_A 1.288 0.92
63_I 68_I 1.285 0.92
152_S 346_L 1.277 0.91
124_P 152_S 1.274 0.91
208_Y 211_L 1.264 0.91
59_N 304_T 1.26 0.90
311_M 379_T 1.254 0.90
121_K 218_V 1.254 0.90
97_L 239_H 1.246 0.90
63_I 312_Q 1.229 0.89
147_N 153_D 1.228 0.89
113_L 218_V 1.227 0.89
109_T 212_G 1.225 0.89
44_D 74_W 1.212 0.88
232_Y 237_L 1.203 0.88
116_L 226_Y 1.196 0.87
237_L 309_V 1.194 0.87
295_S 299_G 1.19 0.87
224_D 294_V 1.189 0.87
240_T 306_D 1.186 0.87
311_M 388_T 1.184 0.86
57_S 92_A 1.181 0.86
57_S 98_Y 1.175 0.86
151_I 214_I 1.174 0.86
241_V 245_L 1.17 0.86
47_I 58_V 1.162 0.85
132_I 213_F 1.16 0.85
412_S 415_L 1.154 0.84
51_V 58_V 1.151 0.84
61_L 304_T 1.15 0.84
244_P 301_F 1.147 0.84
104_T 300_L 1.145 0.84
229_E 233_R 1.142 0.84
117_M 124_P 1.135 0.83
97_L 301_F 1.121 0.82
296_G 299_G 1.113 0.81
329_E 332_K 1.111 0.81
196_Q 199_S 1.105 0.81
60_L 70_Y 1.099 0.80
367_Q 384_V 1.098 0.80
329_E 385_N 1.092 0.80
131_Y 214_I 1.092 0.80
104_T 242_F 1.091 0.80
337_S 343_T 1.088 0.79
180_D 183_Q 1.084 0.79
107_Y 307_I 1.082 0.79
231_I 325_L 1.08 0.79
128_I 214_I 1.079 0.79
128_I 149_L 1.067 0.77
159_G 195_Y 1.066 0.77
324_Q 328_A 1.064 0.77
116_L 215_V 1.061 0.77
80_Y 258_E 1.059 0.77
313_T 318_G 1.058 0.77
126_D 151_I 1.054 0.76
152_S 338_S 1.053 0.76
36_N 39_R 1.051 0.76
30_P 34_G 1.051 0.76
369_Y 383_P 1.05 0.76
95_G 253_Q 1.045 0.75
349_R 371_H 1.04 0.75
376_G 395_K 1.032 0.74
163_A 209_M 1.029 0.74
131_Y 218_V 1.023 0.73
350_V 368_T 1.017 0.73
97_L 253_Q 1.009 0.72
335_T 369_Y 1.007 0.71
50_Q 55_Y 1.004 0.71
195_Y 202_I 1.002 0.71
103_N 379_T 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ivkA10.90781000.303Contact Map0.816
1ci9A20.83641000.351Contact Map0.811
3hlcA10.85251000.359Contact Map0.799
3zytA10.80651000.363Contact Map0.695
4gdnA40.77651000.393Contact Map0.79
2qmiA80.7881000.394Contact Map0.817
1yqsA10.78111000.397Contact Map0.663
2drwA60.80881000.399Contact Map0.759
4e6wA30.74421000.407Contact Map0.713
3tg9A20.76271000.409Contact Map0.719
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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