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PTYBC - PTS system N-acetylmuramic acid-specific EIIBC component
UniProt: P77272 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14163
Length: 474 (461)
Sequences: 1321
Seq/Len: 2.87
PTYBC
Paralog alert: 0.78 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: PTIBC PTTBC PTV3B PTYBC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
407_F 454_V 4.265 1.00
400_G 458_C 3.69 1.00
262_I 266_I 3.325 1.00
305_G 402_A 3.312 1.00
37_V 43_V 3.112 1.00
235_A 271_A 3.062 1.00
352_A 460_F 2.993 1.00
178_G 192_G 2.926 1.00
239_C 263_T 2.729 1.00
9_L 50_L 2.715 1.00
39_D 42_L 2.628 1.00
40_S 58_L 2.479 1.00
238_A 270_L 2.465 1.00
346_Q 387_T 2.454 1.00
16_R 44_D 2.452 1.00
8_E 12_T 2.429 1.00
246_V 262_I 2.426 1.00
55_G 66_V 2.397 1.00
250_M 258_L 2.378 1.00
16_R 50_L 2.312 1.00
407_F 447_V 2.277 1.00
326_L 333_N 2.247 1.00
179_Y 193_A 2.215 1.00
45_P 48_K 2.173 1.00
247_R 255_D 2.17 1.00
403_A 458_C 2.163 1.00
407_F 411_I 2.152 1.00
245_M 249_F 2.149 1.00
24_A 38_H 2.111 1.00
254_L 258_L 2.107 1.00
347_V 374_G 2.097 1.00
78_A 81_E 2.076 1.00
51_E 362_A 2.074 1.00
116_K 185_F 2.053 1.00
47_I 50_L 2.016 1.00
462_F 466_F 2.013 1.00
35_L 65_V 1.911 0.99
7_S 11_N 1.901 0.99
161_F 223_I 1.891 0.99
26_C 35_L 1.887 0.99
348_G 459_G 1.879 0.99
304_A 401_G 1.863 0.99
396_T 466_F 1.844 0.99
241_R 245_M 1.806 0.99
411_I 447_V 1.786 0.99
115_A 184_A 1.749 0.99
135_L 167_K 1.738 0.98
408_I 451_G 1.732 0.98
407_F 451_G 1.724 0.98
13_I 47_I 1.715 0.98
72_A 76_A 1.712 0.98
107_T 112_Q 1.705 0.98
363_L 390_R 1.689 0.98
383_I 394_F 1.685 0.98
17_V 35_L 1.681 0.98
12_T 50_L 1.666 0.98
16_R 46_N 1.657 0.98
46_N 49_T 1.646 0.98
308_L 343_G 1.628 0.97
246_V 250_M 1.627 0.97
241_R 244_G 1.622 0.97
182_A 236_A 1.6 0.97
447_V 450_G 1.591 0.97
187_G 236_A 1.575 0.97
242_I 267_T 1.561 0.96
449_A 453_L 1.56 0.96
242_I 266_I 1.554 0.96
192_G 196_A 1.551 0.96
13_I 67_F 1.549 0.96
258_L 262_I 1.543 0.96
175_I 193_A 1.542 0.96
17_V 37_V 1.53 0.96
11_N 15_T 1.524 0.96
120_I 233_L 1.521 0.96
72_A 78_A 1.512 0.96
179_Y 189_G 1.51 0.95
72_A 75_A 1.493 0.95
396_T 462_F 1.492 0.95
175_I 197_A 1.477 0.95
48_K 389_P 1.472 0.95
309_I 398_C 1.47 0.95
124_L 180_N 1.46 0.94
137_I 141_I 1.452 0.94
390_R 393_P 1.45 0.94
369_G 373_P 1.43 0.93
25_S 36_G 1.424 0.93
349_A 387_T 1.42 0.93
357_A 363_L 1.418 0.93
349_A 397_A 1.417 0.93
461_I 465_L 1.41 0.93
121_F 229_I 1.41 0.93
390_R 468_C 1.409 0.93
340_S 448_Y 1.408 0.93
14_L 23_I 1.387 0.92
133_L 261_L 1.385 0.92
238_A 275_I 1.383 0.92
30_M 378_V 1.378 0.92
234_I 279_G 1.376 0.92
188_T 243_E 1.372 0.91
181_A 185_F 1.371 0.91
300_C 304_A 1.364 0.91
300_C 406_L 1.361 0.91
383_I 397_A 1.359 0.91
187_G 239_C 1.354 0.91
350_A 382_L 1.352 0.91
71_K 75_A 1.332 0.90
255_D 259_T 1.332 0.90
237_W 241_R 1.323 0.89
131_A 168_G 1.32 0.89
187_G 192_G 1.317 0.89
344_A 347_V 1.316 0.89
195_I 264_L 1.315 0.89
168_G 197_A 1.31 0.89
185_F 237_W 1.308 0.89
182_A 192_G 1.305 0.89
354_Y 368_R 1.305 0.89
124_L 173_L 1.299 0.88
185_F 240_A 1.299 0.88
109_G 112_Q 1.298 0.88
289_L 292_H 1.297 0.88
351_L 371_I 1.292 0.88
40_S 63_V 1.288 0.88
348_G 456_W 1.287 0.88
177_V 229_I 1.285 0.88
300_C 405_G 1.28 0.87
396_T 400_G 1.279 0.87
285_G 289_L 1.276 0.87
267_T 271_A 1.276 0.87
13_I 17_V 1.274 0.87
301_A 402_A 1.266 0.86
179_Y 190_V 1.263 0.86
14_L 82_L 1.261 0.86
281_W 285_G 1.258 0.86
353_L 357_A 1.255 0.86
11_N 361_S 1.252 0.86
178_G 196_A 1.241 0.85
198_L 268_A 1.238 0.85
230_I 234_I 1.233 0.84
57_I 66_V 1.231 0.84
446_A 450_G 1.225 0.84
237_W 240_A 1.218 0.83
454_V 458_C 1.217 0.83
400_G 403_A 1.211 0.83
12_T 15_T 1.207 0.83
138_A 159_L 1.203 0.82
395_V 399_L 1.199 0.82
346_Q 349_A 1.197 0.82
289_L 293_L 1.197 0.82
392_K 467_G 1.191 0.82
342_A 346_Q 1.185 0.81
120_I 185_F 1.185 0.81
411_I 454_V 1.181 0.81
407_F 450_G 1.176 0.80
181_A 237_W 1.173 0.80
178_G 186_G 1.172 0.80
116_K 120_I 1.163 0.79
458_C 462_F 1.159 0.79
78_A 82_L 1.152 0.78
26_C 82_L 1.149 0.78
242_I 263_T 1.135 0.77
353_L 393_P 1.134 0.77
58_L 63_V 1.133 0.77
202_G 205_P 1.119 0.76
355_W 460_F 1.119 0.76
406_L 410_L 1.118 0.75
186_G 192_G 1.105 0.74
76_A 80_S 1.102 0.74
71_K 76_A 1.101 0.74
207_A 211_Y 1.099 0.74
126_P 317_Q 1.098 0.74
349_A 393_P 1.096 0.73
308_L 394_F 1.091 0.73
230_I 279_G 1.09 0.73
366_Q 370_A 1.09 0.73
134_L 166_S 1.078 0.72
371_I 375_L 1.076 0.71
113_F 116_K 1.076 0.71
128_F 317_Q 1.075 0.71
282_L 285_G 1.075 0.71
37_V 63_V 1.073 0.71
346_Q 379_G 1.071 0.71
195_I 267_T 1.067 0.71
14_L 79_M 1.06 0.70
100_R 103_K 1.058 0.70
136_G 394_F 1.055 0.69
47_I 65_V 1.054 0.69
182_A 187_G 1.054 0.69
50_L 53_V 1.048 0.69
348_G 352_A 1.047 0.68
181_A 233_L 1.047 0.68
400_G 404_G 1.046 0.68
310_A 319_F 1.043 0.68
309_I 394_F 1.041 0.68
218_F 273_L 1.04 0.68
334_S 337_P 1.038 0.68
242_I 270_L 1.037 0.67
71_K 74_R 1.035 0.67
179_Y 236_A 1.035 0.67
360_H 363_L 1.034 0.67
306_L 309_I 1.03 0.67
178_G 236_A 1.029 0.67
26_C 79_M 1.028 0.66
250_M 259_T 1.028 0.66
9_L 52_G 1.022 0.66
66_V 313_F 1.017 0.65
236_A 240_A 1.016 0.65
43_V 56_V 1.013 0.65
128_F 389_P 1.012 0.65
237_W 275_I 1.011 0.65
353_L 386_V 1.008 0.64
165_F 198_L 1.005 0.64
131_A 169_L 1.004 0.64
43_V 65_V 1.003 0.64
204_N 207_A 1.003 0.64
201_L 205_P 1 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qnqA40.77641000.683Contact Map0.424
3ipjA20.19621000.817Contact Map0.88
1ibaA10.198399.90.825Contact Map0.367
3bp3A20.170999.90.826Contact Map0.693
3u12A20.164642.80.976Contact Map0.396
1m0sA20.15422.90.98Contact Map0.561
1lk5A40.156120.50.98Contact Map0.598
3q9vA20.120318.10.981Contact Map0.119
2hwvA10.130817.60.981Contact Map0.138
4dveA30.259514.90.981Contact Map0.363
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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