| UniProt: | P76518 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13284 | ||
| Length: | 381 (372) | ||
| Sequences: | 4572 | ||
| Seq/Len: | 12.29 |
| YFDE
Paralog alert: 0.70 [within 20: 0.24] - ratio of genomes with paralogs Cluster includes: CAIB FCTA YFDE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 37_R | 72_E | 4.318 | 1.00 | |
| 112_S | 115_T | 4.03 | 1.00 | |
| 28_T | 98_A | 3.566 | 1.00 | |
| 301_Q | 305_V | 3.242 | 1.00 | |
| 80_N | 83_D | 3.102 | 1.00 | |
| 88_I | 119_I | 2.963 | 1.00 | |
| 107_E | 112_S | 2.881 | 1.00 | |
| 126_A | 184_I | 2.84 | 1.00 | |
| 116_L | 123_L | 2.822 | 1.00 | |
| 126_A | 180_L | 2.752 | 1.00 | |
| 189_Y | 192_E | 2.732 | 1.00 | |
| 245_Q | 302_A | 2.659 | 1.00 | |
| 92_K | 119_I | 2.584 | 1.00 | |
| 84_K | 88_I | 2.565 | 1.00 | |
| 302_A | 305_V | 2.559 | 1.00 | |
| 76_L | 87_F | 2.525 | 1.00 | |
| 244_T | 303_A | 2.51 | 1.00 | |
| 301_Q | 306_W | 2.488 | 1.00 | |
| 369_D | 372_G | 2.403 | 1.00 | |
| 243_N | 299_K | 2.361 | 1.00 | |
| 16_I | 91_L | 2.352 | 1.00 | |
| 371_H | 374_Q | 2.348 | 1.00 | |
| 190_G | 198_A | 2.314 | 1.00 | |
| 297_T | 300_T | 2.249 | 1.00 | |
| 113_W | 117_Q | 2.246 | 1.00 | |
| 14_L | 93_Q | 2.24 | 1.00 | |
| 117_Q | 196_R | 2.227 | 1.00 | |
| 301_Q | 309_R | 2.226 | 1.00 | |
| 286_N | 289_I | 2.189 | 1.00 | |
| 14_L | 37_R | 2.178 | 1.00 | |
| 372_G | 376_R | 2.156 | 1.00 | |
| 18_M | 87_F | 2.123 | 1.00 | |
| 16_I | 94_A | 2.09 | 1.00 | |
| 96_V | 184_I | 2.067 | 1.00 | |
| 97_L | 123_L | 2.038 | 1.00 | |
| 85_S | 89_N | 2.032 | 1.00 | |
| 133_H | 201_D | 2.028 | 1.00 | |
| 89_N | 92_K | 2.004 | 1.00 | |
| 34_M | 186_S | 1.984 | 1.00 | |
| 190_G | 355_G | 1.976 | 1.00 | |
| 81_D | 84_K | 1.958 | 1.00 | |
| 292_Q | 296_R | 1.954 | 1.00 | |
| 137_L | 329_L | 1.927 | 1.00 | |
| 182_S | 185_V | 1.92 | 1.00 | |
| 106_M | 111_F | 1.898 | 1.00 | |
| 304_E | 308_A | 1.892 | 1.00 | |
| 190_G | 194_S | 1.883 | 1.00 | |
| 74_V | 375_I | 1.877 | 1.00 | |
| 293_Y | 296_R | 1.876 | 1.00 | |
| 190_G | 196_R | 1.861 | 1.00 | |
| 32_C | 70_G | 1.838 | 1.00 | |
| 294_I | 298_L | 1.826 | 1.00 | |
| 322_S | 325_E | 1.822 | 1.00 | |
| 198_A | 354_S | 1.808 | 1.00 | |
| 17_D | 28_T | 1.793 | 1.00 | |
| 76_L | 83_D | 1.762 | 1.00 | |
| 367_T | 370_Q | 1.753 | 1.00 | |
| 340_E | 343_G | 1.751 | 1.00 | |
| 183_G | 200_V | 1.748 | 1.00 | |
| 268_L | 271_L | 1.733 | 1.00 | |
| 13_L | 188_L | 1.729 | 1.00 | |
| 72_E | 378_E | 1.726 | 1.00 | |
| 196_R | 355_G | 1.718 | 1.00 | |
| 140_A | 311_H | 1.716 | 1.00 | |
| 124_I | 191_R | 1.689 | 1.00 | |
| 159_Y | 162_A | 1.679 | 1.00 | |
| 74_V | 372_G | 1.676 | 1.00 | |
| 127_S | 199_H | 1.642 | 1.00 | |
| 137_L | 140_A | 1.637 | 1.00 | |
| 72_E | 374_Q | 1.618 | 1.00 | |
| 205_F | 332_T | 1.605 | 1.00 | |
| 151_S | 208_T | 1.605 | 1.00 | |
| 262_L | 266_L | 1.605 | 1.00 | |
| 91_L | 120_N | 1.579 | 1.00 | |
| 206_D | 335_R | 1.578 | 1.00 | |
| 289_I | 292_Q | 1.576 | 1.00 | |
| 172_A | 208_T | 1.576 | 1.00 | |
| 268_L | 297_T | 1.572 | 1.00 | |
| 279_S | 282_L | 1.546 | 1.00 | |
| 276_R | 289_I | 1.541 | 1.00 | |
| 264_Q | 272_V | 1.54 | 1.00 | |
| 115_T | 118_E | 1.539 | 1.00 | |
| 240_D | 291_K | 1.532 | 1.00 | |
| 76_L | 86_I | 1.524 | 1.00 | |
| 308_A | 312_E | 1.508 | 1.00 | |
| 340_E | 345_M | 1.506 | 1.00 | |
| 91_L | 116_L | 1.505 | 1.00 | |
| 142_A | 204_M | 1.504 | 1.00 | |
| 149_A | 250_T | 1.5 | 1.00 | |
| 198_A | 357_A | 1.5 | 1.00 | |
| 33_N | 69_H | 1.491 | 1.00 | |
| 77_D | 80_N | 1.481 | 1.00 | |
| 268_L | 293_Y | 1.467 | 1.00 | |
| 244_T | 249_I | 1.447 | 1.00 | |
| 298_L | 306_W | 1.447 | 1.00 | |
| 324_A | 328_K | 1.444 | 1.00 | |
| 297_T | 306_W | 1.444 | 1.00 | |
| 264_Q | 269_T | 1.437 | 1.00 | |
| 328_K | 333_Q | 1.432 | 1.00 | |
| 303_A | 325_E | 1.43 | 1.00 | |
| 265_A | 309_R | 1.419 | 1.00 | |
| 331_Q | 334_A | 1.419 | 1.00 | |
| 242_F | 291_K | 1.415 | 1.00 | |
| 13_L | 189_Y | 1.415 | 1.00 | |
| 91_L | 119_I | 1.395 | 0.99 | |
| 189_Y | 193_K | 1.377 | 0.99 | |
| 113_W | 125_Y | 1.358 | 0.99 | |
| 18_M | 97_L | 1.345 | 0.99 | |
| 243_N | 295_E | 1.337 | 0.99 | |
| 96_V | 124_I | 1.329 | 0.99 | |
| 83_D | 376_R | 1.326 | 0.99 | |
| 88_I | 111_F | 1.323 | 0.99 | |
| 305_V | 309_R | 1.322 | 0.99 | |
| 278_S | 282_L | 1.319 | 0.99 | |
| 265_A | 313_V | 1.303 | 0.99 | |
| 366_A | 371_H | 1.303 | 0.99 | |
| 128_S | 180_L | 1.297 | 0.99 | |
| 183_G | 351_I | 1.29 | 0.99 | |
| 99_E | 127_S | 1.284 | 0.99 | |
| 194_S | 355_G | 1.281 | 0.99 | |
| 48_D | 51_R | 1.279 | 0.99 | |
| 78_L | 109_L | 1.279 | 0.99 | |
| 188_L | 192_E | 1.265 | 0.99 | |
| 175_C | 211_F | 1.258 | 0.99 | |
| 27_G | 181_F | 1.251 | 0.99 | |
| 243_N | 298_L | 1.245 | 0.98 | |
| 122_R | 192_E | 1.238 | 0.98 | |
| 282_L | 285_Q | 1.233 | 0.98 | |
| 276_R | 286_N | 1.226 | 0.98 | |
| 303_A | 319_P | 1.226 | 0.98 | |
| 373_E | 377_Q | 1.224 | 0.98 | |
| 122_R | 191_R | 1.216 | 0.98 | |
| 18_M | 106_M | 1.214 | 0.98 | |
| 203_A | 206_D | 1.209 | 0.98 | |
| 364_G | 370_Q | 1.206 | 0.98 | |
| 137_L | 150_M | 1.204 | 0.98 | |
| 354_S | 357_A | 1.2 | 0.98 | |
| 321_L | 325_E | 1.199 | 0.98 | |
| 271_L | 293_Y | 1.199 | 0.98 | |
| 277_F | 286_N | 1.198 | 0.98 | |
| 161_D | 228_R | 1.193 | 0.98 | |
| 82_H | 85_S | 1.188 | 0.98 | |
| 105_T | 108_K | 1.182 | 0.98 | |
| 15_V | 96_V | 1.179 | 0.98 | |
| 261_A | 264_Q | 1.176 | 0.98 | |
| 8_G | 11_E | 1.163 | 0.97 | |
| 149_A | 318_A | 1.156 | 0.97 | |
| 79_K | 109_L | 1.145 | 0.97 | |
| 73_S | 366_A | 1.14 | 0.97 | |
| 209_L | 326_A | 1.138 | 0.97 | |
| 249_I | 298_L | 1.131 | 0.97 | |
| 113_W | 199_H | 1.128 | 0.97 | |
| 366_A | 370_Q | 1.128 | 0.97 | |
| 305_V | 308_A | 1.126 | 0.97 | |
| 41_V | 74_V | 1.126 | 0.97 | |
| 260_S | 264_Q | 1.12 | 0.96 | |
| 47_G | 51_R | 1.119 | 0.96 | |
| 70_G | 362_M | 1.117 | 0.96 | |
| 74_V | 86_I | 1.108 | 0.96 | |
| 188_L | 191_R | 1.106 | 0.96 | |
| 87_F | 111_F | 1.106 | 0.96 | |
| 144_D | 148_Q | 1.096 | 0.96 | |
| 9_P | 353_I | 1.094 | 0.96 | |
| 249_I | 306_W | 1.091 | 0.96 | |
| 86_I | 376_R | 1.09 | 0.96 | |
| 262_L | 294_I | 1.085 | 0.96 | |
| 131_F | 150_M | 1.084 | 0.96 | |
| 185_V | 189_Y | 1.082 | 0.96 | |
| 150_M | 329_L | 1.077 | 0.95 | |
| 259_F | 263_C | 1.071 | 0.95 | |
| 209_L | 332_T | 1.07 | 0.95 | |
| 136_P | 334_A | 1.057 | 0.95 | |
| 269_T | 272_V | 1.054 | 0.95 | |
| 201_D | 335_R | 1.036 | 0.94 | |
| 280_N | 284_V | 1.032 | 0.94 | |
| 260_S | 273_N | 1.026 | 0.94 | |
| 75_V | 372_G | 1.026 | 0.94 | |
| 90_M | 379_F | 1.025 | 0.93 | |
| 179_Y | 210_S | 1.024 | 0.93 | |
| 87_F | 91_L | 1.016 | 0.93 | |
| 16_I | 87_F | 1.015 | 0.93 | |
| 88_I | 92_K | 1.014 | 0.93 | |
| 266_L | 297_T | 1.012 | 0.93 | |
| 88_I | 115_T | 1.007 | 0.93 | |
| 255_N | 258_L | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4hl6A | 6 | 0.9974 | 100 | -0.024 | Contact Map | 0.864 |
| 4ed9A | 1 | 0.9843 | 100 | -0.002 | Contact Map | 0.753 |
| 1q7eA | 1 | 0.9869 | 100 | 0.001 | Contact Map | 0.742 |
| 2vjqA | 4 | 0.9816 | 100 | 0.008 | Contact Map | 0.814 |
| 3ubmA | 4 | 0.9921 | 100 | 0.01 | Contact Map | 0.794 |
| 1xk7A | 3 | 0.9764 | 100 | 0.014 | Contact Map | 0.77 |
| 2yimA | 4 | 0.9344 | 100 | 0.061 | Contact Map | 0.744 |
| 2g04A | 6 | 0.9291 | 100 | 0.091 | Contact Map | 0.759 |
| 2a9fA | 2 | 0.5354 | 84.3 | 0.956 | Contact Map | 0.285 |
| 1vl6A | 4 | 0.5407 | 83.6 | 0.956 | Contact Map | 0.48 |
Sequence Conservation (Image Generated using WebLogo v3)