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OPENSEQ.org
DCEA - Glutamate decarboxylase alpha
UniProt: P69908 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG50009
Length: 466 (420)
Sequences: 2805
Seq/Len: 6.68
DCEA
Paralog alert: 0.47 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DCEA DCEB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_F 222_P 5.71 1.00
195_I 233_D 4.899 1.00
244_A 248_G 3.748 1.00
352_Y 435_E 3.674 1.00
229_K 266_R 3.589 1.00
205_V 231_Q 3.587 1.00
356_E 359_K 3.251 1.00
193_R 196_E 3.249 1.00
364_E 381_K 3.244 1.00
183_R 188_F 2.95 1.00
35_H 337_E 2.925 1.00
74_K 78_L 2.794 1.00
402_R 443_A 2.685 1.00
207_P 223_L 2.664 1.00
181_P 193_R 2.519 1.00
356_E 438_L 2.448 1.00
195_I 234_T 2.29 1.00
231_Q 240_M 2.287 1.00
232_A 266_R 2.269 1.00
352_Y 431_M 2.244 1.00
356_E 435_E 2.242 1.00
156_N 199_D 2.17 1.00
207_P 240_M 2.162 1.00
198_C 230_F 2.126 1.00
355_D 359_K 2.098 1.00
109_H 261_D 2.077 1.00
123_T 129_A 2.073 1.00
180_I 197_A 2.049 1.00
229_K 233_D 2.009 1.00
191_P 230_F 2.001 1.00
193_R 197_A 1.983 1.00
364_E 383_K 1.98 1.00
137_M 204_G 1.971 1.00
205_V 223_L 1.966 1.00
244_A 270_I 1.956 1.00
103_M 332_L 1.94 1.00
157_L 170_A 1.938 1.00
354_A 365_F 1.923 1.00
156_N 202_T 1.902 1.00
156_N 176_E 1.862 1.00
228_D 240_M 1.809 1.00
360_L 442_K 1.758 1.00
190_D 193_R 1.741 1.00
183_R 190_D 1.738 1.00
167_H 179_E 1.737 1.00
352_Y 356_E 1.712 1.00
34_L 336_R 1.696 1.00
397_E 401_L 1.682 1.00
207_P 220_P 1.671 1.00
230_F 233_D 1.665 1.00
194_M 223_L 1.655 1.00
348_Q 431_M 1.651 1.00
398_R 447_Y 1.634 1.00
228_D 266_R 1.629 1.00
195_I 199_D 1.614 1.00
129_A 271_S 1.613 1.00
191_P 222_P 1.608 1.00
221_Q 229_K 1.604 1.00
156_N 178_R 1.603 1.00
135_M 173_W 1.601 1.00
133_G 287_V 1.585 1.00
234_T 238_I 1.584 1.00
192_K 196_E 1.581 1.00
222_P 229_K 1.571 1.00
70_E 74_K 1.564 0.99
230_F 234_T 1.561 0.99
130_C 165_C 1.559 0.99
198_C 238_I 1.541 0.99
44_Q 48_D 1.533 0.99
180_I 189_M 1.526 0.99
221_Q 266_R 1.517 0.99
228_D 232_A 1.488 0.99
435_E 439_E 1.482 0.99
195_I 230_F 1.46 0.99
261_D 264_L 1.448 0.99
41_V 44_Q 1.445 0.99
357_I 363_Y 1.438 0.99
394_D 398_R 1.424 0.99
340_T 344_N 1.421 0.99
349_V 434_A 1.418 0.99
399_L 406_V 1.417 0.99
423_I 437_L 1.412 0.99
221_Q 259_V 1.407 0.99
204_G 241_H 1.4 0.99
220_P 240_M 1.374 0.98
229_K 232_A 1.372 0.98
291_D 294_A 1.37 0.98
354_A 358_A 1.358 0.98
440_D 443_A 1.355 0.98
134_G 204_G 1.35 0.98
131_M 172_Y 1.344 0.98
158_V 197_A 1.341 0.98
107_L 336_R 1.324 0.98
354_A 357_I 1.317 0.98
247_G 270_I 1.312 0.98
395_L 444_S 1.307 0.98
260_W 263_R 1.305 0.98
220_P 242_I 1.305 0.98
38_R 41_V 1.3 0.97
124_I 128_E 1.297 0.97
255_A 263_R 1.29 0.97
336_R 340_T 1.273 0.97
422_R 425_C 1.264 0.97
337_E 341_K 1.263 0.97
353_L 425_C 1.233 0.96
366_I 381_K 1.221 0.96
198_C 202_T 1.219 0.96
355_D 358_A 1.216 0.96
350_A 378_V 1.205 0.95
44_Q 47_N 1.2 0.95
144_R 148_A 1.194 0.95
360_L 363_Y 1.193 0.95
180_I 193_R 1.192 0.95
159_C 177_L 1.175 0.95
103_M 106_D 1.172 0.95
73_H 77_D 1.17 0.94
108_W 272_A 1.17 0.94
34_L 337_E 1.169 0.94
417_D 422_R 1.165 0.94
170_A 177_L 1.163 0.94
228_D 264_L 1.158 0.94
199_D 202_T 1.158 0.94
158_V 202_T 1.157 0.94
289_W 295_L 1.156 0.94
416_T 422_R 1.147 0.94
274_G 327_Q 1.145 0.94
60_L 63_F 1.144 0.94
209_F 247_G 1.142 0.93
103_M 328_Y 1.14 0.93
97_D 319_R 1.134 0.93
341_K 345_A 1.132 0.93
45_I 332_L 1.126 0.93
430_E 433_F 1.125 0.93
242_I 267_V 1.125 0.93
351_A 355_D 1.122 0.93
77_D 81_N 1.122 0.93
183_R 186_Q 1.121 0.93
95_A 99_R 1.12 0.93
246_S 376_P 1.118 0.93
353_L 378_V 1.116 0.92
199_D 234_T 1.115 0.92
398_R 401_L 1.115 0.92
196_E 200_E 1.115 0.92
409_F 412_G 1.112 0.92
130_C 241_H 1.107 0.92
266_R 290_R 1.107 0.92
43_F 47_N 1.107 0.92
223_L 240_M 1.104 0.92
356_E 442_K 1.103 0.92
106_D 109_H 1.103 0.92
178_R 197_A 1.102 0.92
161_P 181_P 1.101 0.92
159_C 179_E 1.098 0.92
367_C 371_P 1.093 0.91
167_H 231_Q 1.092 0.91
111_P 291_D 1.09 0.91
192_K 195_I 1.088 0.91
272_A 286_W 1.088 0.91
37_M 42_A 1.087 0.91
398_R 402_R 1.087 0.91
345_A 349_V 1.085 0.91
129_A 285_G 1.085 0.91
436_L 440_D 1.081 0.91
415_A 418_I 1.078 0.91
197_A 200_E 1.076 0.91
444_S 447_Y 1.075 0.90
103_M 335_G 1.074 0.90
90_Y 94_A 1.071 0.90
120_G 288_I 1.062 0.90
205_V 240_M 1.062 0.90
181_P 197_A 1.06 0.90
446_K 450_D 1.042 0.89
208_T 212_T 1.04 0.88
144_R 147_A 1.034 0.88
54_G 57_R 1.034 0.88
228_D 242_I 1.031 0.88
189_M 223_L 1.027 0.88
134_G 169_F 1.02 0.87
368_T 371_P 1.019 0.87
322_G 325_I 1.017 0.87
432_D 436_L 1.017 0.87
370_R 373_E 1.016 0.87
106_D 335_G 1.016 0.87
103_M 331_F 1.014 0.87
205_V 238_I 1.008 0.86
210_G 375_I 1.006 0.86
127_S 165_C 1.006 0.86
320_P 323_Q 1.002 0.86
439_E 443_A 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2dgkA60.971000.49Contact Map0.679
3vp6A20.93991000.506Contact Map0.777
4e1oA60.92491000.511Contact Map0.78
2jisA20.91851000.513Contact Map0.796
1js3A20.94641000.514Contact Map0.688
2qmaA20.91421000.517Contact Map0.702
3hbxA60.96781000.517Contact Map0.71
3k40A20.92271000.529Contact Map0.718
3mc6A10.92921000.544Contact Map0.626
3f9tA20.81971000.593Contact Map0.758
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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