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OPENSEQ.org
YFEO - Putative ion-transport protein YfeO
UniProt: P67729 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14156
Length: 418 (399)
Sequences: 2564
Seq/Len: 6.43
YFEO
Paralog alert: 0.56 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CLCA CLCB YFEO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
358_G 390_V 4.372 1.00
115_V 315_A 3.29 1.00
302_F 338_M 3.025 1.00
116_S 312_L 3.004 1.00
117_L 315_A 2.924 1.00
127_N 151_A 2.902 1.00
110_G 115_V 2.849 1.00
222_D 351_T 2.634 1.00
116_S 308_K 2.628 1.00
354_C 390_V 2.626 1.00
242_W 246_R 2.379 1.00
66_T 113_G 2.357 1.00
232_I 335_L 2.275 1.00
305_A 331_V 2.249 1.00
168_L 372_F 2.158 1.00
226_G 354_C 2.14 1.00
230_A 234_I 2.075 1.00
271_L 311_A 1.982 1.00
192_A 196_G 1.972 1.00
236_A 359_I 1.965 1.00
234_I 398_L 1.962 1.00
229_V 339_L 1.927 1.00
267_I 314_V 1.862 1.00
234_I 397_L 1.848 1.00
110_G 117_L 1.842 1.00
281_F 284_L 1.837 1.00
72_L 76_F 1.828 1.00
247_L 317_A 1.821 1.00
246_R 250_M 1.821 1.00
67_G 71_G 1.794 1.00
265_G 269_G 1.787 1.00
135_G 144_R 1.755 1.00
360_V 364_T 1.743 1.00
246_R 249_A 1.742 1.00
224_L 228_I 1.741 1.00
272_G 280_L 1.718 1.00
16_A 19_I 1.711 1.00
230_A 394_A 1.679 1.00
251_M 318_S 1.674 1.00
240_A 312_L 1.662 1.00
110_G 320_F 1.637 1.00
328_A 363_V 1.614 1.00
236_A 335_L 1.591 1.00
305_A 338_M 1.584 0.99
361_L 391_M 1.58 0.99
63_L 66_T 1.574 0.99
93_A 132_V 1.561 0.99
365_R 399_A 1.557 0.99
153_A 170_F 1.546 0.99
149_I 175_N 1.528 0.99
251_M 264_G 1.526 0.99
103_L 321_R 1.51 0.99
110_G 315_A 1.501 0.99
237_G 362_V 1.494 0.99
32_K 36_V 1.473 0.99
164_V 372_F 1.461 0.99
18_A 22_A 1.445 0.99
122_P 160_F 1.437 0.99
277_P 280_L 1.436 0.99
36_V 40_L 1.435 0.99
103_L 155_T 1.434 0.99
290_M 334_A 1.433 0.99
287_M 333_V 1.43 0.99
104_I 126_V 1.418 0.99
71_G 261_L 1.415 0.99
360_V 370_S 1.409 0.99
231_A 393_P 1.408 0.99
154_G 192_A 1.39 0.98
153_A 157_G 1.383 0.98
235_A 239_V 1.377 0.98
374_A 387_L 1.376 0.98
301_Y 338_M 1.372 0.98
108_I 112_A 1.368 0.98
233_A 335_L 1.362 0.98
362_V 394_A 1.36 0.98
371_L 388_C 1.352 0.98
309_L 331_V 1.342 0.98
227_A 231_A 1.34 0.98
115_V 320_F 1.339 0.98
329_V 356_I 1.313 0.97
259_L 262_G 1.307 0.97
69_A 109_L 1.306 0.97
20_G 24_S 1.305 0.97
375_A 384_L 1.296 0.97
26_I 30_V 1.289 0.97
24_S 28_I 1.283 0.97
256_N 259_L 1.28 0.97
24_S 34_A 1.27 0.97
286_E 330_F 1.263 0.97
301_Y 334_A 1.261 0.97
231_A 397_L 1.256 0.96
226_G 390_V 1.248 0.96
340_H 352_V 1.245 0.96
357_L 391_M 1.244 0.96
233_A 359_I 1.242 0.96
264_G 318_S 1.239 0.96
225_S 339_L 1.229 0.96
82_G 85_P 1.222 0.96
393_P 397_L 1.216 0.95
301_Y 337_L 1.208 0.95
298_T 338_M 1.208 0.95
387_L 391_M 1.203 0.95
79_G 103_L 1.2 0.95
270_I 273_V 1.185 0.95
243_C 313_V 1.185 0.95
80_H 84_D 1.18 0.94
106_A 321_R 1.174 0.94
247_L 313_V 1.17 0.94
35_S 39_N 1.168 0.94
229_V 233_A 1.166 0.94
37_L 112_A 1.165 0.94
85_P 128_I 1.164 0.94
116_S 315_A 1.162 0.94
103_L 122_P 1.159 0.94
299_S 306_V 1.153 0.93
133_A 137_R 1.153 0.93
227_A 393_P 1.152 0.93
149_I 189_P 1.149 0.93
155_T 234_I 1.14 0.93
337_L 352_V 1.128 0.92
123_I 326_F 1.127 0.92
364_T 377_V 1.125 0.92
101_P 105_V 1.123 0.92
237_G 394_A 1.121 0.92
87_C 90_L 1.118 0.92
189_P 193_A 1.118 0.92
150_L 155_T 1.114 0.92
351_T 355_A 1.106 0.91
239_V 309_L 1.102 0.91
262_G 266_F 1.101 0.91
26_I 130_L 1.101 0.91
296_F 301_Y 1.098 0.91
105_V 309_L 1.097 0.91
369_L 373_M 1.092 0.91
103_L 121_H 1.091 0.91
371_L 384_L 1.09 0.91
349_A 352_V 1.088 0.91
365_R 398_L 1.086 0.90
18_A 21_I 1.085 0.90
190_L 392_L 1.084 0.90
305_A 334_A 1.083 0.90
237_G 363_V 1.075 0.90
152_S 174_L 1.07 0.90
188_A 192_A 1.062 0.89
117_L 322_G 1.061 0.89
270_I 274_I 1.061 0.89
165_A 366_D 1.061 0.89
228_I 235_A 1.061 0.89
299_S 303_L 1.061 0.89
220_M 224_L 1.06 0.89
21_I 203_F 1.059 0.89
235_A 397_L 1.058 0.89
247_L 393_P 1.057 0.89
238_M 398_L 1.052 0.89
251_M 254_M 1.048 0.88
171_S 174_L 1.048 0.88
279_S 311_A 1.046 0.88
159_L 173_T 1.043 0.88
305_A 335_L 1.041 0.88
117_L 316_A 1.041 0.88
117_L 320_F 1.039 0.88
234_I 394_A 1.038 0.88
340_H 348_A 1.037 0.88
240_A 315_A 1.032 0.87
222_D 226_G 1.031 0.87
119_P 125_T 1.028 0.87
30_V 34_A 1.026 0.87
328_A 360_V 1.026 0.87
132_V 144_R 1.023 0.87
309_L 313_V 1.022 0.87
29_V 32_K 1.021 0.86
312_L 331_V 1.02 0.86
350_I 383_L 1.02 0.86
80_H 83_P 1.019 0.86
159_L 377_V 1.018 0.86
166_A 170_F 1.017 0.86
155_T 159_L 1.012 0.86
232_I 250_M 1.012 0.86
70_V 110_G 1.011 0.86
80_H 103_L 1.011 0.86
99_A 103_L 1.011 0.86
217_Q 228_I 1.009 0.86
333_V 337_L 1.008 0.86
144_R 148_T 1.007 0.85
21_I 25_L 1.003 0.85
156_I 322_G 1.003 0.85
100_L 129_A 1.003 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nd0A20.98331000.197Contact Map0.641
4eneA20.98091000.2Contact Map0.671
3orgA40.96891000.272Contact Map0.586
1jcnA20.220199.10.866Contact Map0
3usbA20.234488.20.946Contact Map0
4avfA40.172226.60.966Contact Map0
3k3fA10.650720.10.968Contact Map0.136
1uqrA120.124450.976Contact Map0.401
4ezcA30.71534.90.976Contact Map0.122
2ksfA10.2444.60.976Contact Map0.248
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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