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YDDM - Uncharacterized HTH-type transcriptional regulator YddM
UniProt: P67699 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13784
Length: 94 (91)
Sequences: 1062
Seq/Len: 11.67

YDDM
Paralog alert: 0.52 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: YBAQ YDDM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
69_N 73_A 2.384 1.00
26_E 30_A 2.293 1.00
57_S 64_P 2.289 1.00
37_T 52_M 2.264 1.00
25_R 29_R 2.174 1.00
71_Q 75_S 2.136 1.00
40_R 46_A 2.054 1.00
25_R 35_P 2.05 1.00
24_L 39_S 2.011 1.00
57_S 63_S 2 1.00
30_A 59_V 1.99 1.00
57_S 62_S 1.852 1.00
77_A 81_K 1.85 1.00
39_S 43_T 1.807 1.00
15_E 18_D 1.632 1.00
36_S 39_S 1.601 1.00
36_S 40_R 1.546 1.00
41_L 48_L 1.441 1.00
27_F 56_L 1.4 0.99
11_D 15_E 1.373 0.99
41_L 52_M 1.369 0.99
85_V 88_L 1.363 0.99
40_R 45_K 1.341 0.99
14_Q 18_D 1.32 0.99
64_P 76_L 1.289 0.99
53_A 64_P 1.274 0.99
24_L 36_S 1.25 0.99
22_V 27_F 1.203 0.98
33_I 52_M 1.197 0.98
54_I 79_A 1.177 0.98
33_I 55_K 1.167 0.97
27_F 38_A 1.161 0.97
24_L 42_L 1.159 0.97
35_P 39_S 1.159 0.97
62_S 66_M 1.156 0.97
59_V 91_L 1.146 0.97
7_P 12_I 1.139 0.97
8_R 71_Q 1.133 0.97
13_I 41_L 1.116 0.96
47_A 75_S 1.097 0.96
51_E 55_K 1.093 0.96
74_W 78_E 1.088 0.96
53_A 65_Q 1.078 0.95
63_S 66_M 1.068 0.95
65_Q 69_N 1.063 0.95
4_A 7_P 1.05 0.94
37_T 46_A 1.049 0.94
6_H 78_E 1.033 0.94
12_I 70_L 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ictA1199.40.502Contact Map0.586
3cecA10.978799.30.526Contact Map0.739
3trbA2199.30.531Contact Map0.805
2ebyA2199.20.548Contact Map0.797
2a6cA20.76698.70.639Contact Map0.538
3g7dA1198.70.64Contact Map0.416
3qq6A20.797998.60.647Contact Map0.735
3fmyA10.744798.60.65Contact Map0.435
3g5gA140.840498.50.656Contact Map0.751
3o9xA20.744798.50.657Contact Map0.434

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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