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SFGH1 - S-formylglutathione hydrolase FrmB
UniProt: P51025 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13295
Length: 277 (274)
Sequences: 3276
Seq/Len: 11.96
SFGH1
Paralog alert: 0.61 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: SFGH1 SFGH2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
155_A 165_V 3.941 1.00
105_N 119_D 3.939 1.00
167_A 170_P 3.032 1.00
75_I 135_A 2.875 1.00
130_M 135_A 2.835 1.00
20_Y 27_E 2.807 1.00
234_E 238_Q 2.777 1.00
46_L 142_S 2.51 1.00
96_L 186_A 2.498 1.00
130_M 139_K 2.433 1.00
118_Y 158_N 2.431 1.00
181_Q 192_K 2.299 1.00
43_L 75_I 2.293 1.00
247_R 265_E 2.266 1.00
119_D 123_N 2.256 1.00
46_L 74_I 2.191 1.00
168_F 266_H 2.167 1.00
219_L 250_E 2.117 1.00
20_Y 25_K 2.115 1.00
165_V 213_I 2.108 1.00
236_I 240_M 2.104 1.00
45_V 77_V 2.093 1.00
231_P 248_Y 2.065 1.00
21_S 124_E 2.054 1.00
38_A 134_P 2.009 1.00
37_K 73_N 1.972 1.00
129_V 135_A 1.968 1.00
18_R 27_E 1.952 1.00
234_E 244_T 1.933 1.00
77_V 129_V 1.897 1.00
166_S 266_H 1.895 1.00
32_V 77_V 1.877 1.00
47_Y 130_M 1.865 1.00
72_H 267_I 1.707 1.00
153_V 198_Y 1.682 1.00
118_Y 154_L 1.68 1.00
2_E 18_R 1.674 1.00
128_L 132_H 1.667 1.00
86_S 98_Q 1.662 1.00
47_Y 139_K 1.637 1.00
18_R 29_N 1.601 1.00
216_D 262_F 1.598 1.00
48_W 142_S 1.595 1.00
235_K 239_E 1.584 1.00
48_W 59_F 1.57 1.00
19_H 120_Y 1.541 1.00
34_L 75_I 1.529 1.00
38_A 43_L 1.522 1.00
90_D 98_Q 1.503 1.00
122_R 158_N 1.484 1.00
126_P 162_Y 1.484 1.00
196_L 202_S 1.48 1.00
67_R 71_E 1.48 1.00
105_N 116_K 1.464 1.00
219_L 248_Y 1.437 1.00
215_V 233_L 1.42 1.00
23_S 119_D 1.416 1.00
126_P 139_K 1.4 0.99
152_L 172_V 1.391 0.99
91_A 98_Q 1.385 0.99
264_G 268_A 1.379 0.99
41_E 73_N 1.368 0.99
153_V 157_R 1.358 0.99
126_P 130_M 1.348 0.99
65_M 76_V 1.346 0.99
120_Y 125_L 1.346 0.99
16_M 29_N 1.344 0.99
21_S 24_L 1.339 0.99
45_V 135_A 1.337 0.99
3_L 15_N 1.337 0.99
47_Y 126_P 1.335 0.99
3_L 6_K 1.328 0.99
193_D 196_L 1.318 0.99
237_C 244_T 1.3 0.99
118_Y 157_R 1.295 0.99
169_S 259_V 1.285 0.99
29_N 56_E 1.273 0.99
148_G 167_A 1.267 0.99
141_I 151_A 1.263 0.99
173_S 232_N 1.255 0.99
236_I 239_E 1.255 0.99
87_H 98_Q 1.246 0.98
219_L 249_H 1.245 0.98
63_S 256_Y 1.236 0.98
123_N 127_D 1.231 0.98
126_P 161_E 1.229 0.98
214_M 247_R 1.221 0.98
28_M 120_Y 1.221 0.98
122_R 161_E 1.213 0.98
170_P 230_T 1.212 0.98
234_E 248_Y 1.21 0.98
48_W 263_I 1.209 0.98
122_R 127_D 1.203 0.98
232_N 235_K 1.2 0.98
17_Y 30_V 1.197 0.98
15_N 133_F 1.195 0.98
194_A 197_D 1.19 0.98
152_L 170_P 1.169 0.97
45_V 75_I 1.166 0.97
123_N 158_N 1.166 0.97
138_K 163_V 1.166 0.97
49_L 150_G 1.155 0.97
215_V 234_E 1.153 0.97
224_Y 231_P 1.152 0.97
68_Y 264_G 1.152 0.97
153_V 200_P 1.136 0.97
47_Y 77_V 1.133 0.97
152_L 167_A 1.125 0.97
30_V 120_Y 1.111 0.96
231_P 235_K 1.105 0.96
33_Y 36_P 1.105 0.96
49_L 117_M 1.104 0.96
109_A 112_N 1.103 0.96
149_L 200_P 1.095 0.96
149_L 153_V 1.094 0.96
37_K 43_L 1.09 0.96
6_K 13_W 1.089 0.96
147_G 150_G 1.083 0.96
17_Y 128_L 1.079 0.95
46_L 76_V 1.07 0.95
60_I 78_A 1.065 0.95
75_I 133_F 1.064 0.95
47_Y 129_V 1.059 0.95
16_M 56_E 1.057 0.95
230_T 246_I 1.056 0.95
202_S 205_S 1.051 0.94
122_R 154_L 1.046 0.94
141_I 154_L 1.044 0.94
22_Q 25_K 1.04 0.94
204_I 240_M 1.039 0.94
173_S 176_Q 1.031 0.94
144_H 259_V 1.027 0.94
116_K 119_D 1.022 0.93
43_L 134_P 1.014 0.93
23_S 124_E 1.014 0.93
30_V 125_L 1.011 0.93
145_S 254_H 1.008 0.93
68_Y 72_H 1.006 0.93
172_V 233_L 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4folA411000.365Contact Map0.721
3ls2A40.99641000.368Contact Map0.828
4b6gA20.99281000.38Contact Map0.866
3i6yA20.99641000.403Contact Map0.806
3e4dA60.99281000.406Contact Map0.794
3fcxA20.99641000.424Contact Map0.835
2uz0A40.87361000.483Contact Map0.757
4h18A40.9351000.504Contact Map0.722
1jjfA10.83751000.505Contact Map0.791
1r88A20.89891000.513Contact Map0.731
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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