OPENSEQ.org - YJHQ - ECOLI GREMLIN

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YJHQ - Uncharacterized N-acetyltransferase YjhQ

UniProt:	P39368	Sequence MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMHILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTAQPMTLTGHIRCADPDETGALT	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG12559
Length:	181 (172)
Sequences:	929
Seq/Len:	5.40

YJHQ
Paralog alert: 0.24 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: YHBS YJHQ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
65_F	104_G	5.643	1.00
105_I	116_V	3.646	1.00
85_L	101_I	3.527	1.00
105_I	130_F	3.068	1.00
23_E	86_A	2.947	1.00
20_R	37_A	2.466	1.00
121_H	126_P	2.416	1.00
103_T	107_H	2.364	1.00
62_H	86_A	2.156	1.00
89_P	92_Q	2.091	1.00
98_G	127_R	2.088	1.00
9_H	15_D	2.034	1.00
11_T	50_S	1.944	1.00
80_H	108_L	1.904	1.00
79_M	115_T	1.902	1.00
126_P	154_M	1.835	1.00
81_I	171_C	1.823	1.00
107_H	110_L	1.774	1.00
98_G	128_H	1.728	1.00
60_V	96_V	1.725	1.00
51_L	103_T	1.7	1.00
22_V	59_A	1.698	1.00
9_H	54_R	1.671	1.00
103_T	106_E	1.624	0.99
157_S	161_Q	1.588	0.99
54_R	57_G	1.585	0.99
68_A	169_I	1.571	0.99
63_I	104_G	1.562	0.99
122_A	152_C	1.517	0.99
30_S	33_A	1.484	0.99
25_R	88_I	1.455	0.98
80_H	113_C	1.451	0.98
119_L	171_C	1.44	0.98
82_L	101_I	1.417	0.98
87_V	96_V	1.41	0.98
82_L	118_V	1.404	0.98
52_L	59_A	1.395	0.98
23_E	62_H	1.383	0.98
11_T	40_L	1.362	0.97
53_A	96_V	1.355	0.97
35_L	83_A	1.345	0.97
70_F	167_G	1.336	0.97
63_I	85_L	1.328	0.97
119_L	153_W	1.321	0.97
135_G	147_E	1.32	0.96
124_Y	128_H	1.303	0.96
82_L	116_V	1.298	0.96
91_Y	94_M	1.273	0.95
20_R	24_T	1.245	0.95
131_E	136_D	1.228	0.94
83_A	118_V	1.207	0.93
114_Q	159_T	1.198	0.93
134_A	138_G	1.181	0.92
81_I	153_W	1.181	0.92
63_I	100_L	1.176	0.92
23_E	36_V	1.168	0.92
55_Y	91_Y	1.165	0.92
98_G	102_R	1.16	0.92
157_S	163_M	1.16	0.92
63_I	101_I	1.154	0.91
24_T	33_A	1.141	0.91
42_D	172_A	1.133	0.90
84_P	125_Y	1.126	0.90
128_H	156_Q	1.125	0.90
51_L	104_G	1.116	0.89
121_H	154_M	1.098	0.88
70_F	165_L	1.093	0.88
131_E	157_S	1.089	0.88
7_T	54_R	1.074	0.87
61_G	100_L	1.059	0.86
101_I	128_H	1.05	0.85
134_A	155_M	1.05	0.85
34_D	38_S	1.049	0.85
30_S	34_D	1.044	0.85
106_E	109_R	1.04	0.84
46_R	111_M	1.038	0.84
29_F	33_A	1.033	0.84
88_I	91_Y	1.024	0.83
8_F	51_L	1.021	0.83
46_R	172_A	1.002	0.81
65_F	108_L	1	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1cjwA	1	0.8398	99.7	0.682	Contact Map	0.713
1kuxA	1	0.8729	99.7	0.682	Contact Map	0.726
2i00A	6	0.9834	99.7	0.684	Contact Map	0.716
3r1kA	1	0.9834	99.7	0.687	Contact Map	0.676
3n7zA	6	0.9724	99.6	0.688	Contact Map	0.738
3sxnA	6	0.9834	99.6	0.689	Contact Map	0.723
3te4A	1	0.8564	99.6	0.691	Contact Map	0.73
2hv2A	6	0.9779	99.6	0.691	Contact Map	0.711
4e2aA	2	0.8564	99.6	0.694	Contact Map	0.773
1tiqA	2	0.8785	99.6	0.694	Contact Map	0.757

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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