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OPENSEQ.org
NUDK - GDP-mannose pyrophosphatase NudK
UniProt: P37128 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12410
Length: 191 (184)
Sequences: 2628
Seq/Len: 14.28
NUDK
Paralog alert: 0.41 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ADPP NUDE NUDK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
49_T 83_S 3.212 1.00
111_E 135_E 2.55 1.00
110_G 136_Y 2.542 1.00
81_I 156_L 2.535 1.00
54_N 59_T 2.534 1.00
94_E 98_R 2.534 1.00
113_R 135_E 2.432 1.00
163_A 181_L 2.427 1.00
165_E 169_T 2.335 1.00
64_R 154_E 2.302 1.00
92_E 95_V 2.286 1.00
59_T 159_P 2.248 1.00
15_D 19_T 2.242 1.00
91_D 99_K 2.21 1.00
61_V 157_E 2.194 1.00
102_I 108_E 2.147 1.00
93_P 130_H 2.147 1.00
65_Q 82_E 2.126 1.00
59_T 157_E 2.046 1.00
6_T 28_T 1.996 1.00
117_E 128_L 1.94 1.00
114_K 130_H 1.921 1.00
28_T 34_V 1.908 1.00
98_R 112_V 1.894 1.00
88_L 96_C 1.89 1.00
162_Q 165_E 1.872 1.00
50_I 97_I 1.87 1.00
51_L 180_L 1.86 1.00
114_K 117_E 1.824 1.00
111_E 136_Y 1.782 1.00
12_I 15_D 1.761 1.00
23_I 43_D 1.746 1.00
117_E 130_H 1.714 1.00
64_R 156_L 1.712 1.00
54_N 157_E 1.655 1.00
159_P 162_Q 1.648 1.00
158_L 166_M 1.635 1.00
166_M 171_E 1.628 1.00
11_K 24_T 1.593 1.00
61_V 107_Y 1.591 1.00
43_D 126_T 1.588 1.00
16_N 40_E 1.565 1.00
94_E 112_V 1.553 1.00
164_L 185_Q 1.515 1.00
95_V 98_R 1.505 1.00
101_A 109_V 1.49 1.00
10_D 23_I 1.479 1.00
96_C 99_K 1.479 1.00
7_L 68_V 1.451 1.00
115_L 133_I 1.444 1.00
119_Y 173_R 1.442 1.00
25_Y 68_V 1.439 1.00
83_S 180_L 1.395 0.99
110_G 138_D 1.37 0.99
121_S 127_E 1.368 0.99
26_D 34_V 1.365 0.99
56_K 59_T 1.345 0.99
9_K 26_D 1.339 0.99
80_L 122_P 1.333 0.99
10_D 25_Y 1.325 0.99
91_D 96_C 1.301 0.99
11_K 22_N 1.29 0.99
93_P 132_F 1.287 0.99
68_V 77_S 1.273 0.99
78_G 173_R 1.242 0.98
114_K 132_F 1.206 0.98
10_D 21_H 1.184 0.98
118_L 179_L 1.181 0.98
61_V 155_V 1.176 0.98
167_I 178_V 1.167 0.97
70_T 80_L 1.164 0.97
182_N 186_T 1.139 0.97
67_R 82_E 1.134 0.97
58_K 160_F 1.134 0.97
165_E 168_K 1.124 0.97
145_G 148_V 1.116 0.96
13_L 20_L 1.11 0.96
30_K 152_D 1.107 0.96
108_E 138_D 1.083 0.96
119_Y 128_L 1.079 0.95
60_V 83_S 1.056 0.95
8_I 28_T 1.055 0.95
62_L 158_L 1.054 0.95
158_L 163_A 1.052 0.95
54_N 107_Y 1.05 0.94
49_T 129_I 1.036 0.94
88_L 93_P 1.033 0.94
120_M 124_G 1.02 0.93
174_D 177_T 1.011 0.93
24_T 38_K 1.011 0.93
98_R 102_I 1.009 0.93
26_D 38_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1g0sA20.99481000.256Contact Map0.834
2dscA20.94241000.3Contact Map0.781
1vhzA20.92151000.306Contact Map0.796
3o6zA211000.338Contact Map0.794
1mk1A10.93721000.35Contact Map0.806
2yvpA10.9111000.398Contact Map0.796
1v8yA10.86911000.44Contact Map0.815
3q91A40.952999.90.471Contact Map0.716
2w4eA20.73399.90.525Contact Map0.763
2fvvA10.879699.80.58Contact Map0.615
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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