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HOFB - Protein transport protein HofB homolog
UniProt: P36645 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12106
Length: 461 (451)
Sequences: 2182
Seq/Len: 4.84
HOFB
Paralog alert: 0.54 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: GSPE HOFB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
354_L 382_A 4.969 1.00
405_T 428_A 4.454 1.00
210_A 344_L 3.798 1.00
179_K 245_N 3.742 1.00
207_F 235_A 3.63 1.00
320_S 323_E 3.623 1.00
360_R 383_P 3.383 1.00
411_L 424_H 3.255 1.00
134_T 180_V 3.045 1.00
354_L 447_T 3.017 1.00
244_I 287_V 2.996 1.00
359_R 380_W 2.988 1.00
357_H 387_H 2.965 1.00
208_A 238_K 2.823 1.00
411_L 416_T 2.52 1.00
221_T 316_L 2.518 1.00
249_V 276_V 2.517 1.00
360_R 381_Q 2.508 1.00
346_I 401_V 2.496 1.00
247_C 280_L 2.476 1.00
426_R 435_E 2.445 1.00
219_L 314_S 2.361 1.00
85_L 133_L 2.352 1.00
163_N 186_Q 2.346 1.00
361_Q 378_P 2.329 1.00
353_K 396_T 2.316 1.00
293_I 302_A 2.309 1.00
437_G 451_L 2.305 1.00
179_K 261_N 2.227 1.00
54_W 59_M 2.206 1.00
150_L 269_A 2.173 1.00
175_R 253_V 2.163 1.00
408_I 421_L 2.105 1.00
404_I 412_I 2.08 1.00
320_S 422_E 2.074 1.00
211_L 235_A 2.059 1.00
417_D 420_S 2.054 1.00
405_T 424_H 2.048 1.00
362_Q 381_Q 2.046 1.00
354_L 359_R 2.029 1.00
167_F 182_L 2.007 1.00
424_H 428_A 1.963 1.00
172_L 263_T 1.958 1.00
436_N 440_A 1.952 1.00
109_Y 130_G 1.929 1.00
143_L 171_T 1.911 1.00
28_A 54_W 1.897 1.00
204_L 208_A 1.893 1.00
141_G 169_I 1.878 1.00
322_C 402_L 1.87 1.00
385_C 388_C 1.866 1.00
41_L 49_I 1.863 1.00
202_L 431_R 1.856 1.00
171_T 180_V 1.853 1.00
209_H 403_P 1.85 1.00
185_L 255_I 1.834 1.00
439_L 443_Q 1.824 1.00
424_H 427_Q 1.811 1.00
438_C 442_E 1.807 1.00
396_T 445_L 1.801 1.00
355_C 358_C 1.778 1.00
382_A 447_T 1.778 1.00
20_A 47_K 1.754 1.00
407_V 428_A 1.737 1.00
239_L 287_V 1.729 1.00
121_P 124_D 1.711 1.00
118_V 352_R 1.701 0.99
170_A 283_Q 1.696 0.99
355_C 388_C 1.686 0.99
203_Q 399_F 1.68 0.99
118_V 453_R 1.679 0.99
379_H 441_V 1.671 0.99
325_L 342_L 1.659 0.99
10_C 67_Q 1.644 0.99
431_R 439_L 1.64 0.99
179_K 247_C 1.636 0.99
96_R 393_Y 1.623 0.99
249_V 280_L 1.619 0.99
358_C 388_C 1.618 0.99
440_A 445_L 1.616 0.99
213_Q 343_T 1.604 0.99
203_Q 401_V 1.594 0.99
167_F 184_L 1.592 0.99
263_T 280_L 1.576 0.99
362_Q 379_H 1.573 0.99
55_T 58_Q 1.573 0.99
434_F 455_L 1.564 0.99
355_C 385_C 1.551 0.99
203_Q 436_N 1.549 0.99
110_R 121_P 1.541 0.99
18_L 28_A 1.539 0.99
200_Q 203_Q 1.521 0.99
266_H 269_A 1.516 0.99
140_L 156_F 1.504 0.98
218_V 311_L 1.496 0.98
219_L 293_I 1.49 0.98
199_M 399_F 1.468 0.98
358_C 385_C 1.466 0.98
174_C 261_N 1.456 0.98
30_V 59_M 1.444 0.98
299_A 333_V 1.434 0.98
300_E 304_K 1.432 0.98
354_L 383_P 1.417 0.97
102_I 109_Y 1.414 0.97
239_L 313_L 1.414 0.97
108_A 124_D 1.413 0.97
441_V 451_L 1.408 0.97
272_T 275_G 1.397 0.97
329_Q 338_L 1.394 0.97
24_V 50_E 1.389 0.97
201_P 205_A 1.371 0.97
407_V 427_Q 1.361 0.97
402_L 430_M 1.359 0.96
221_T 318_T 1.351 0.96
9_L 13_Y 1.343 0.96
29_V 51_I 1.339 0.96
293_I 314_S 1.339 0.96
407_V 424_H 1.336 0.96
425_A 430_M 1.336 0.96
240_N 246_I 1.331 0.96
203_Q 206_D 1.323 0.96
304_K 330_Q 1.314 0.96
31_D 34_S 1.309 0.95
199_M 207_F 1.305 0.95
210_A 401_V 1.29 0.95
322_C 421_L 1.285 0.95
410_Q 414_A 1.285 0.95
10_C 63_A 1.277 0.95
416_T 420_S 1.275 0.94
414_A 420_S 1.274 0.94
276_V 280_L 1.273 0.94
14_H 30_V 1.273 0.94
26_H 52_T 1.27 0.94
103_E 112_R 1.268 0.94
93_L 160_L 1.262 0.94
37_L 41_L 1.236 0.93
156_F 167_F 1.226 0.93
38_L 51_I 1.215 0.92
357_H 393_Y 1.215 0.92
446_T 450_E 1.205 0.92
426_R 432_T 1.194 0.92
406_P 409_R 1.194 0.92
199_M 397_A 1.186 0.91
143_L 180_V 1.181 0.91
304_K 307_Q 1.18 0.91
25_V 45_T 1.176 0.91
205_A 209_H 1.175 0.91
364_E 379_H 1.173 0.91
307_Q 337_M 1.172 0.91
224_T 285_P 1.171 0.90
384_G 388_C 1.168 0.90
347_A 433_L 1.167 0.90
165_V 186_Q 1.164 0.90
218_V 344_L 1.162 0.90
392_F 447_T 1.162 0.90
206_D 403_P 1.16 0.90
303_I 333_V 1.157 0.90
19_D 26_H 1.156 0.90
170_A 181_V 1.156 0.90
351_V 446_T 1.149 0.89
18_L 52_T 1.148 0.89
35_H 39_D 1.138 0.89
115_I 120_H 1.137 0.89
425_A 429_G 1.137 0.89
97_A 115_I 1.136 0.89
322_C 422_E 1.13 0.88
396_T 440_A 1.125 0.88
137_L 169_I 1.123 0.88
27_V 41_L 1.119 0.88
322_C 430_M 1.109 0.87
381_Q 449_E 1.106 0.87
245_N 261_N 1.106 0.87
158_V 167_F 1.096 0.86
11_L 64_S 1.087 0.85
392_F 446_T 1.086 0.85
277_L 301_I 1.085 0.85
16_V 62_H 1.084 0.85
356_P 359_R 1.082 0.85
232_L 289_M 1.077 0.85
138_K 178_E 1.076 0.85
116_D 352_R 1.075 0.85
113_L 122_L 1.074 0.85
141_G 156_F 1.062 0.84
274_Q 297_E 1.057 0.83
23_E 47_K 1.057 0.83
88_T 111_I 1.05 0.83
223_P 349_R 1.05 0.83
432_T 435_E 1.046 0.82
14_H 60_E 1.043 0.82
203_Q 346_I 1.043 0.82
80_P 83_E 1.033 0.81
342_L 345_V 1.031 0.81
329_Q 415_N 1.029 0.81
200_Q 439_L 1.028 0.81
200_Q 440_A 1.025 0.81
354_L 380_W 1.024 0.80
13_Y 37_L 1.021 0.80
361_Q 380_W 1.012 0.79
352_R 450_E 1.012 0.79
211_L 313_L 1.01 0.79
14_H 56_R 1.008 0.79
144_D 268_R 1.007 0.79
438_C 448_F 1.006 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
tr|GY00.87641000.388Contact Map
1p9rA10.89371000.39Contact Map0.75
2ewvA10.73541000.58Contact Map0.614
3jvvA30.71151000.587Contact Map0.597
2oap120.93281000.65Contact Map0.326
2eyuA20.50331000.699Contact Map0.777
4ihqA30.94361000.704Contact Map0.311
4bloA120.61821000.711Contact Map0.094
2b8tA40.42521000.8Contact Map0.464
2gzaA30.66811000.812Contact Map0.594
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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