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OPENSEQ.org
DUSC - tRNA-dihydrouridine synthase C
UniProt: P33371 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12022
Length: 315 (309)
Sequences: 2629
Seq/Len: 8.51
DUSC
Paralog alert: 0.50 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: DUSA DUSB DUSC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_E 255_K 5.092 1.00
190_R 219_D 4.966 1.00
211_Q 215_I 3.186 1.00
204_W 208_S 3.117 1.00
205_D 208_S 2.97 1.00
127_R 163_T 2.51 1.00
210_Q 214_A 2.416 1.00
123_A 162_A 2.385 1.00
124_K 128_E 2.359 1.00
77_L 94_L 2.358 1.00
199_A 212_C 2.357 1.00
187_G 191_Q 2.351 1.00
299_N 302_D 2.329 1.00
184_Q 215_I 2.31 1.00
158_Q 194_N 2.275 1.00
193_L 197_V 2.226 1.00
63_T 90_W 2.205 1.00
142_L 185_A 2.112 1.00
188_D 191_Q 2.111 1.00
203_I 212_C 2.09 1.00
254_Q 304_A 2.065 1.00
208_S 211_Q 2.021 1.00
158_Q 195_I 2.016 1.00
96_C 119_I 1.994 1.00
120_Y 160_A 1.983 1.00
71_G 77_L 1.971 1.00
258_R 304_A 1.95 1.00
204_W 226_G 1.934 1.00
207_Q 211_Q 1.928 1.00
77_L 126_M 1.927 1.00
150_K 189_I 1.925 1.00
114_K 144_W 1.912 1.00
180_H 183_W 1.899 1.00
130_V 134_L 1.892 1.00
27_D 238_K 1.845 1.00
120_Y 124_K 1.832 1.00
174_Q 182_D 1.825 1.00
115_D 118_L 1.786 1.00
167_V 189_I 1.778 1.00
94_L 126_M 1.775 1.00
75_Q 79_E 1.754 1.00
85_V 133_H 1.746 1.00
79_E 82_A 1.743 1.00
121_Q 124_K 1.736 1.00
66_R 91_G 1.731 1.00
254_Q 308_Q 1.727 1.00
301_P 305_R 1.716 1.00
81_A 130_V 1.711 1.00
119_I 153_I 1.683 1.00
293_H 309_A 1.666 1.00
146_S 174_Q 1.64 1.00
298_N 302_D 1.634 1.00
302_D 305_R 1.628 1.00
164_E 198_I 1.625 1.00
28_L 91_G 1.624 1.00
120_Y 156_A 1.612 1.00
292_Q 296_V 1.612 1.00
186_I 199_A 1.607 1.00
117_E 121_Q 1.606 1.00
297_L 306_A 1.599 1.00
199_A 218_C 1.597 1.00
82_A 86_E 1.592 1.00
223_I 237_V 1.572 1.00
130_V 136_V 1.572 1.00
185_A 188_D 1.567 1.00
274_K 280_L 1.562 1.00
198_I 222_M 1.551 1.00
211_Q 214_A 1.535 1.00
151_F 192_R 1.535 1.00
110_A 172_K 1.527 1.00
113_L 153_I 1.526 1.00
158_Q 193_L 1.526 1.00
155_D 158_Q 1.516 1.00
120_Y 159_Q 1.511 1.00
4_L 198_I 1.51 1.00
28_L 66_R 1.489 1.00
180_H 202_E 1.479 1.00
297_L 302_D 1.472 1.00
304_A 308_Q 1.464 0.99
138_V 162_A 1.446 0.99
124_K 160_A 1.428 0.99
235_R 248_E 1.424 0.99
305_R 309_A 1.417 0.99
155_D 192_R 1.414 0.99
230_I 236_V 1.408 0.99
169_G 186_I 1.405 0.99
140_V 167_V 1.4 0.99
198_I 220_A 1.393 0.99
190_R 197_V 1.382 0.99
3_V 221_V 1.378 0.99
118_L 121_Q 1.371 0.99
213_M 218_C 1.367 0.99
78_A 129_A 1.356 0.99
16_V 20_L 1.345 0.99
145_D 148_E 1.326 0.99
23_V 252_L 1.326 0.99
275_Q 279_Y 1.317 0.99
113_L 140_V 1.311 0.99
209_A 221_V 1.308 0.99
85_V 134_L 1.308 0.99
152_E 155_D 1.306 0.99
127_R 136_V 1.294 0.98
138_V 157_V 1.291 0.98
123_A 160_A 1.29 0.98
117_E 156_A 1.262 0.98
182_D 185_A 1.256 0.98
85_V 130_V 1.249 0.98
137_S 164_E 1.244 0.98
4_L 28_L 1.243 0.98
82_A 129_A 1.226 0.98
247_P 251_A 1.225 0.98
123_A 157_V 1.214 0.97
85_V 131_P 1.212 0.97
187_G 215_I 1.206 0.97
167_V 197_V 1.201 0.97
142_L 182_D 1.201 0.97
112_L 122_G 1.194 0.97
154_A 193_L 1.186 0.97
156_A 160_A 1.183 0.97
30_I 66_R 1.169 0.96
73_F 76_W 1.154 0.96
276_W 279_Y 1.146 0.96
202_E 225_R 1.146 0.96
97_G 200_N 1.145 0.96
21_T 64_L 1.143 0.96
274_K 279_Y 1.136 0.96
150_K 185_A 1.13 0.96
155_D 159_Q 1.129 0.95
250_V 254_Q 1.124 0.95
275_Q 280_L 1.113 0.95
74_P 78_A 1.113 0.95
266_G 269_H 1.11 0.95
74_P 118_L 1.101 0.95
183_W 212_C 1.094 0.94
30_I 166_V 1.092 0.94
119_I 157_V 1.091 0.94
127_R 162_A 1.089 0.94
9_E 33_F 1.087 0.94
114_K 145_D 1.081 0.94
75_Q 125_A 1.078 0.94
212_C 216_S 1.077 0.94
227_A 234_S 1.066 0.93
140_V 153_I 1.064 0.93
5_L 227_A 1.063 0.93
301_P 304_A 1.058 0.93
245_P 248_E 1.057 0.93
212_C 218_C 1.056 0.93
153_I 157_V 1.054 0.93
166_V 222_M 1.043 0.92
3_V 237_V 1.042 0.92
113_L 119_I 1.041 0.92
209_A 237_V 1.04 0.92
77_L 122_G 1.033 0.92
6_A 224_G 1.028 0.92
199_A 203_I 1.027 0.92
154_A 189_I 1.016 0.91
255_K 259_L 1.01 0.91
35_R 70_L 1.003 0.90
210_Q 240_N 1.001 0.90
75_Q 121_Q 1 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3w9zA111000.3Contact Map0.696
4bfaA211000.314Contact Map0.725
1vhnA10.95241000.368Contact Map0.745
3b0pA20.94921000.377Contact Map0.749
1gteA40.9461000.621Contact Map0.685
3l5aA10.92381000.632Contact Map0.669
3sgzA30.78731000.633Contact Map0.579
1p4cA10.8541000.639Contact Map0.566
3tjlA10.89521000.639Contact Map0.512
4jicA30.84441000.646Contact Map0.656
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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