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OPENSEQ.org
PSUT - Putative pseudouridine transporter
UniProt: P33024 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12032
Length: 416 (414)
Sequences: 781
Seq/Len: 1.89
PSUT
Paralog alert: 0.56 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: NUPC NUPX PSUT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
315_D 349_E 3.427 1.00
313_W 316_A 2.923 1.00
383_R 386_E 2.692 1.00
105_I 262_V 2.69 1.00
69_Y 278_G 2.398 1.00
337_S 340_P 2.379 1.00
170_R 389_Q 2.329 1.00
12_V 308_I 2.24 1.00
23_N 26_S 2.194 0.99
319_A 356_I 2.153 0.99
20_L 396_A 2.146 0.99
175_T 214_I 2.146 0.99
277_N 295_E 2.121 0.99
161_V 168_M 2.017 0.99
57_E 61_L 1.962 0.99
392_L 396_A 1.959 0.99
295_E 337_S 1.919 0.98
22_V 393_R 1.899 0.98
252_A 268_A 1.896 0.98
78_F 98_A 1.859 0.98
157_I 179_S 1.837 0.98
212_G 401_S 1.8 0.97
319_A 352_T 1.782 0.97
18_F 24_K 1.776 0.97
72_A 75_A 1.772 0.97
77_I 267_M 1.767 0.97
114_L 244_F 1.763 0.97
17_A 219_I 1.762 0.97
253_M 261_G 1.726 0.96
284_G 292_A 1.67 0.95
8_V 307_W 1.67 0.95
248_A 272_I 1.602 0.94
284_G 293_S 1.599 0.93
118_I 244_F 1.589 0.93
15_A 19_L 1.584 0.93
65_K 68_S 1.578 0.93
256_L 260_A 1.536 0.92
275_L 279_I 1.535 0.92
123_L 127_I 1.533 0.91
154_Q 372_V 1.533 0.91
55_A 58_Q 1.53 0.91
309_M 403_L 1.51 0.91
170_R 386_E 1.507 0.91
117_Y 241_P 1.504 0.90
303_A 317_N 1.502 0.90
17_A 216_F 1.5 0.90
7_V 411_F 1.499 0.90
325_Q 337_S 1.488 0.90
129_G 140_K 1.48 0.89
138_I 143_S 1.475 0.89
166_D 382_K 1.472 0.89
27_I 219_I 1.47 0.89
5_R 307_W 1.466 0.89
189_M 378_A 1.464 0.89
165_I 380_S 1.452 0.88
276_I 294_L 1.451 0.88
366_F 392_L 1.442 0.88
119_G 122_G 1.437 0.88
364_A 402_N 1.437 0.88
155_N 261_G 1.433 0.87
305_L 308_I 1.424 0.87
155_N 258_I 1.42 0.87
392_L 395_L 1.414 0.86
66_V 111_L 1.413 0.86
71_D 100_R 1.403 0.86
1_M 117_Y 1.396 0.85
209_A 405_S 1.395 0.85
294_L 298_F 1.386 0.85
258_I 261_G 1.383 0.85
209_A 212_G 1.383 0.85
45_I 49_F 1.382 0.85
257_K 260_A 1.363 0.84
169_N 223_A 1.353 0.83
145_V 157_I 1.352 0.83
327_L 399_T 1.342 0.82
51_P 55_A 1.34 0.82
55_A 59_A 1.34 0.82
309_M 407_T 1.329 0.81
88_V 93_A 1.296 0.79
23_N 224_T 1.295 0.79
104_A 187_S 1.282 0.78
190_I 258_I 1.278 0.78
303_A 320_G 1.278 0.78
127_I 131_I 1.266 0.77
313_W 320_G 1.266 0.77
273_I 329_I 1.263 0.77
14_L 219_I 1.258 0.76
311_V 352_T 1.255 0.76
220_L 396_A 1.254 0.76
104_A 190_I 1.253 0.76
209_A 402_N 1.247 0.75
127_I 130_S 1.246 0.75
401_S 405_S 1.245 0.75
169_N 172_E 1.241 0.75
247_A 251_G 1.239 0.75
261_G 265_V 1.239 0.75
22_V 170_R 1.236 0.74
402_N 405_S 1.235 0.74
154_Q 187_S 1.233 0.74
296_S 300_Y 1.233 0.74
338_F 351_K 1.226 0.73
201_Y 358_F 1.226 0.73
303_A 313_W 1.226 0.73
204_A 270_V 1.225 0.73
198_P 342_L 1.22 0.73
7_V 11_V 1.219 0.73
33_G 37_L 1.214 0.72
311_V 319_A 1.214 0.72
30_R 34_A 1.212 0.72
299_G 321_S 1.209 0.72
148_T 152_L 1.204 0.72
131_I 135_A 1.201 0.71
44_G 412_F 1.199 0.71
154_Q 327_L 1.198 0.71
15_A 301_V 1.191 0.70
259_A 263_A 1.187 0.70
17_A 400_L 1.181 0.69
358_F 405_S 1.177 0.69
358_F 402_N 1.177 0.69
171_N 223_A 1.176 0.69
306_A 323_I 1.175 0.69
220_L 397_A 1.175 0.69
280_I 293_S 1.166 0.68
364_A 399_T 1.162 0.68
106_I 255_G 1.158 0.67
338_F 356_I 1.156 0.67
369_I 387_I 1.149 0.66
159_A 258_I 1.148 0.66
191_G 195_M 1.147 0.66
187_S 258_I 1.147 0.66
148_T 160_I 1.145 0.66
149_T 183_S 1.145 0.66
300_Y 317_N 1.144 0.66
97_F 367_G 1.14 0.65
271_A 367_G 1.134 0.65
138_I 214_I 1.134 0.65
172_E 294_L 1.132 0.65
74_S 99_F 1.132 0.65
110_A 329_I 1.131 0.65
67_M 338_F 1.13 0.64
22_V 221_S 1.128 0.64
199_I 203_L 1.128 0.64
2_D 351_K 1.127 0.64
82_V 99_F 1.127 0.64
109_T 376_F 1.124 0.64
184_I 339_S 1.123 0.64
174_F 397_A 1.119 0.63
283_I 286_W 1.112 0.63
285_G 291_N 1.109 0.62
114_L 272_I 1.106 0.62
184_I 188_M 1.105 0.62
43_G 200_D 1.102 0.62
295_E 325_Q 1.101 0.62
14_L 32_V 1.1 0.61
113_S 117_Y 1.096 0.61
409_A 412_F 1.094 0.61
41_A 45_I 1.094 0.61
65_K 69_Y 1.088 0.60
238_E 293_S 1.088 0.60
142_E 218_R 1.086 0.60
295_E 340_P 1.08 0.59
149_T 210_I 1.078 0.59
20_L 220_L 1.075 0.59
326_K 332_F 1.074 0.59
321_S 325_Q 1.072 0.58
114_L 248_A 1.07 0.58
209_A 358_F 1.069 0.58
40_I 408_I 1.067 0.58
366_F 399_T 1.065 0.58
255_G 259_A 1.062 0.57
188_M 380_S 1.056 0.57
188_M 265_V 1.055 0.57
327_L 364_A 1.046 0.56
39_Q 212_G 1.045 0.56
292_A 297_I 1.042 0.55
128_L 411_F 1.036 0.55
285_G 401_S 1.036 0.55
244_F 248_A 1.035 0.54
212_G 405_S 1.032 0.54
28_S 137_N 1.032 0.54
200_D 357_S 1.031 0.54
54_W 57_E 1.031 0.54
188_M 367_G 1.029 0.54
64_H 68_S 1.028 0.54
145_V 179_S 1.027 0.54
259_A 262_V 1.026 0.53
354_A 413_I 1.025 0.53
116_Y 121_M 1.023 0.53
297_I 320_G 1.022 0.53
60_A 270_V 1.02 0.53
109_T 149_T 1.019 0.53
6_S 410_G 1.016 0.52
110_A 248_A 1.013 0.52
77_I 266_V 1.013 0.52
155_N 375_A 1.011 0.52
112_I 150_I 1.011 0.52
105_I 115_L 1.009 0.52
161_V 410_G 1.006 0.51
235_S 293_S 1.005 0.51
117_Y 189_M 1 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tijA10.99761000.097Contact Map0.539
2l2tA20.07454.10.986Contact Map0.26
2ks1B10.072140.986Contact Map0.272
1q90G10.06253.50.986Contact Map0.564
4h44G10.06253.10.986Contact Map0.222
4ikvA10.41592.70.987Contact Map0.135
2jwaA20.06972.40.987Contact Map0.299
2k1kA20.06012.10.988Contact Map0.013
4b19A10.06011.80.988Contact Map0.524
2lotA10.07451.60.988Contact Map0.18
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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