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OPENSEQ.org
YIHQ - Alpha-glucosidase YihQ
UniProt: P32138 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11843
Length: 678 (609)
Sequences: 788
Seq/Len: 1.29
YIHQ
Paralog alert: 0.55 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: XYLS YIHQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
597_D 629_Y 4.88 1.00
519_E 622_G 3.62 1.00
240_T 245_R 3.55 1.00
352_G 356_K 3.368 1.00
324_N 400_G 3.329 1.00
616_A 628_L 3.097 1.00
347_E 389_V 3.075 1.00
315_Q 318_S 2.785 1.00
616_A 661_F 2.565 1.00
505_I 528_S 2.502 1.00
348_A 354_L 2.483 1.00
612_D 666_S 2.481 1.00
453_F 466_T 2.475 1.00
618_V 626_W 2.396 0.99
273_D 277_N 2.334 0.99
600_T 629_Y 2.325 0.99
150_T 183_P 2.303 0.99
268_C 287_A 2.259 0.99
380_P 417_H 2.258 0.99
594_Y 608_L 2.229 0.99
470_A 489_A 2.216 0.99
572_L 609_L 2.176 0.99
196_H 459_T 2.173 0.99
269_Q 322_Q 2.17 0.99
517_S 621_E 2.12 0.98
654_P 657_K 2.112 0.98
375_V 382_A 2.099 0.98
279_G 559_A 2.093 0.98
345_C 373_G 2.036 0.98
321_K 325_Q 2.001 0.97
608_L 635_W 1.995 0.97
274_T 277_N 1.975 0.97
280_V 562_T 1.946 0.97
250_P 253_I 1.935 0.96
505_I 534_M 1.922 0.96
357_D 361_G 1.841 0.95
346_E 350_Q 1.831 0.95
590_L 608_L 1.825 0.95
284_G 329_Q 1.797 0.94
287_A 330_F 1.779 0.94
435_K 439_E 1.774 0.94
388_E 392_K 1.77 0.93
272_L 282_V 1.757 0.93
283_N 566_T 1.749 0.93
514_M 541_R 1.695 0.91
529_A 561_M 1.692 0.91
384_A 388_E 1.686 0.91
121_L 213_H 1.675 0.91
627_T 650_T 1.667 0.90
234_S 237_E 1.652 0.90
351_H 381_E 1.648 0.90
435_K 464_Y 1.644 0.90
490_A 503_S 1.642 0.90
625_D 650_T 1.641 0.90
128_H 140_D 1.633 0.89
630_L 646_G 1.589 0.87
613_I 660_V 1.564 0.86
335_N 406_F 1.557 0.86
263_G 266_E 1.551 0.86
575_A 588_R 1.55 0.86
555_I 559_A 1.527 0.84
387_K 443_E 1.524 0.84
576_V 586_V 1.509 0.83
608_L 631_P 1.508 0.83
605_Y 626_W 1.503 0.83
476_D 481_D 1.492 0.83
630_L 661_F 1.483 0.82
588_R 635_W 1.478 0.82
536_T 543_G 1.464 0.81
499_G 579_N 1.458 0.80
640_T 660_V 1.455 0.80
484_A 620_E 1.452 0.80
588_R 611_R 1.45 0.80
353_Y 379_N 1.44 0.79
149_W 431_A 1.433 0.79
506_G 521_L 1.43 0.79
391_K 443_E 1.398 0.76
348_A 375_V 1.384 0.75
259_L 263_G 1.383 0.75
365_V 368_G 1.368 0.74
492_S 496_T 1.368 0.74
594_Y 633_D 1.367 0.74
275_M 545_N 1.364 0.74
416_L 422_A 1.364 0.74
578_L 588_R 1.363 0.74
402_W 437_N 1.361 0.74
590_L 631_P 1.357 0.73
577_A 581_K 1.356 0.73
94_N 106_E 1.349 0.73
494_A 585_P 1.349 0.73
379_N 417_H 1.331 0.71
252_W 385_W 1.329 0.71
590_L 606_Q 1.328 0.71
431_A 461_S 1.328 0.71
274_T 278_A 1.326 0.71
333_Y 403_M 1.313 0.70
457_G 461_S 1.313 0.70
525_C 536_T 1.311 0.70
568_L 613_I 1.305 0.69
606_Q 614_L 1.301 0.69
387_K 440_A 1.3 0.69
588_R 593_H 1.292 0.68
490_A 501_H 1.292 0.68
255_D 263_G 1.291 0.68
349_A 352_G 1.291 0.68
333_Y 406_F 1.29 0.68
637_H 640_T 1.287 0.68
252_W 401_G 1.287 0.68
403_M 406_F 1.285 0.67
345_C 362_D 1.284 0.67
241_A 245_R 1.28 0.67
525_C 558_F 1.277 0.67
184_Q 243_L 1.272 0.66
387_K 439_E 1.27 0.66
352_G 379_N 1.264 0.66
597_D 600_T 1.258 0.65
578_L 584_L 1.255 0.65
549_D 553_E 1.249 0.64
651_V 661_F 1.241 0.64
240_T 497_G 1.236 0.63
334_I 390_I 1.234 0.63
335_N 533_M 1.231 0.63
237_E 582_S 1.227 0.62
639_W 660_V 1.221 0.62
615_V 660_V 1.221 0.62
208_S 619_H 1.219 0.61
409_Y 422_A 1.214 0.61
112_L 115_N 1.214 0.61
323_W 583_G 1.212 0.61
419_G 424_I 1.207 0.60
271_K 546_W 1.205 0.60
616_A 626_W 1.204 0.60
451_L 466_T 1.199 0.60
454_M 465_S 1.191 0.59
273_D 322_Q 1.19 0.59
96_S 110_D 1.185 0.58
292_G 327_G 1.185 0.58
255_D 259_L 1.184 0.58
522_L 655_I 1.184 0.58
473_Q 489_A 1.182 0.58
303_M 306_W 1.178 0.58
60_K 80_L 1.169 0.57
353_Y 382_A 1.167 0.57
531_T 607_Y 1.167 0.57
578_L 582_S 1.167 0.57
493_L 496_T 1.167 0.57
367_F 372_G 1.165 0.56
337_Y 374_V 1.164 0.56
365_V 369_E 1.164 0.56
258_T 335_N 1.164 0.56
329_Q 385_W 1.162 0.56
636_V 664_A 1.161 0.56
237_E 245_R 1.16 0.56
490_A 587_M 1.158 0.56
335_N 508_Y 1.157 0.56
629_Y 632_E 1.156 0.55
240_T 585_P 1.155 0.55
249_L 576_V 1.152 0.55
129_I 187_F 1.152 0.55
259_L 335_N 1.151 0.55
270_K 635_W 1.151 0.55
95_I 106_E 1.149 0.55
308_W 316_L 1.148 0.55
628_L 661_F 1.147 0.55
288_Q 406_F 1.143 0.54
281_K 566_T 1.143 0.54
335_N 407_G 1.141 0.54
618_V 660_V 1.141 0.54
237_E 240_T 1.14 0.54
199_N 220_D 1.14 0.54
561_M 658_P 1.138 0.54
284_G 385_W 1.134 0.53
270_K 274_T 1.131 0.53
494_A 588_R 1.131 0.53
92_T 108_Q 1.128 0.53
232_Y 595_E 1.121 0.52
527_F 619_H 1.12 0.52
106_E 112_L 1.119 0.52
426_H 535_R 1.117 0.52
347_E 351_H 1.115 0.51
388_E 443_E 1.114 0.51
201_C 219_E 1.113 0.51
132_C 253_I 1.11 0.51
618_V 654_P 1.109 0.51
356_K 380_P 1.104 0.50
566_T 573_K 1.103 0.50
349_A 362_D 1.102 0.50
653_A 657_K 1.099 0.50
571_Y 612_D 1.099 0.50
519_E 623_R 1.097 0.50
653_A 659_P 1.096 0.49
281_K 665_D 1.093 0.49
229_A 235_L 1.089 0.49
356_K 362_D 1.089 0.49
465_S 513_E 1.087 0.49
186_T 194_Y 1.085 0.48
584_L 592_L 1.084 0.48
276_R 328_V 1.084 0.48
386_F 607_Y 1.082 0.48
62_Q 80_L 1.08 0.48
404_A 433_W 1.076 0.48
578_L 611_R 1.075 0.47
629_Y 647_G 1.075 0.47
267_V 542_P 1.073 0.47
282_V 328_V 1.072 0.47
97_A 104_L 1.07 0.47
225_R 242_L 1.07 0.47
255_D 265_T 1.07 0.47
279_G 563_T 1.069 0.47
239_L 459_T 1.067 0.47
606_Q 617_P 1.059 0.46
288_Q 335_N 1.058 0.46
96_S 108_Q 1.056 0.46
112_L 116_R 1.053 0.45
352_G 381_E 1.049 0.45
528_S 531_T 1.048 0.45
272_L 328_V 1.048 0.45
288_Q 333_Y 1.047 0.45
407_G 433_W 1.047 0.45
243_L 462_Q 1.044 0.44
348_A 385_W 1.044 0.44
403_M 407_G 1.043 0.44
71_I 80_L 1.04 0.44
338_V 348_A 1.04 0.44
422_A 426_H 1.034 0.43
461_S 498_H 1.033 0.43
546_W 549_D 1.032 0.43
379_N 385_W 1.029 0.43
385_W 388_E 1.028 0.43
587_M 658_P 1.028 0.43
135_Q 491_L 1.027 0.43
229_A 234_S 1.025 0.42
93_L 97_A 1.023 0.42
481_D 620_E 1.021 0.42
338_V 630_L 1.018 0.42
63_E 79_W 1.018 0.42
234_S 596_D 1.017 0.42
516_R 520_L 1.017 0.42
180_T 482_G 1.016 0.42
494_A 578_L 1.015 0.42
376_D 408_E 1.015 0.42
517_S 520_L 1.014 0.41
377_L 429_W 1.014 0.41
94_N 108_Q 1.014 0.41
100_Q 106_E 1.013 0.41
132_C 207_F 1.011 0.41
355_A 414_T 1.01 0.41
253_I 331_L 1.008 0.41
337_Y 482_G 1.006 0.41
332_A 399_C 1.005 0.41
230_D 235_L 1.004 0.40
384_A 443_E 1.004 0.40
590_L 600_T 1.002 0.40
59_D 64_K 1 0.40
93_L 105_L 1 0.40
503_S 531_T 1 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lppA40.93811000.263Contact Map0.664
3l4yA10.93221000.264Contact Map0.635
3topA20.93221000.274Contact Map0.654
3w37A10.93221000.279Contact Map0.648
4ba0A10.93071000.305Contact Map0.573
3nsxA20.82451000.318Contact Map0.588
4kmqA10.94691000.324Contact Map0.579
2f2hA60.93071000.326Contact Map0.647
2g3mA60.83631000.334Contact Map0.638
4amwA40.95281000.351Contact Map0.64
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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