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OPENSEQ.org
GLVG - Putative inactive 6-phospho-alpha-glucosidase
UniProt: P31450 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11708
Length: 212 (206)
Sequences: 699
Seq/Len: 3.39
GLVG
Paralog alert: 0.65 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: AGAL CHBF GLVG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_E 135_K 4.413 1.00
71_P 132_Y 3.251 1.00
75_F 137_S 3.149 1.00
105_V 113_P 2.946 1.00
133_M 142_M 2.779 1.00
49_A 67_Y 2.628 1.00
34_A 64_A 2.33 1.00
73_V 76_S 2.232 1.00
131_D 134_E 2.176 1.00
50_E 53_K 2.085 1.00
46_E 50_E 2.074 1.00
134_E 160_R 2.073 1.00
34_A 66_S 1.964 1.00
70_D 73_V 1.929 1.00
49_A 53_K 1.926 1.00
130_V 156_T 1.895 1.00
87_V 125_G 1.879 0.99
5_S 36_K 1.869 0.99
133_M 163_A 1.793 0.99
141_W 164_K 1.773 0.99
128_E 131_D 1.752 0.99
133_M 137_S 1.726 0.99
72_E 132_Y 1.697 0.99
187_D 190_Q 1.684 0.99
12_G 39_D 1.61 0.98
36_K 68_T 1.594 0.98
122_S 125_G 1.545 0.97
176_E 188_R 1.539 0.97
20_V 35_L 1.524 0.97
41_D 89_K 1.472 0.96
22_M 170_D 1.447 0.96
123_I 155_A 1.432 0.95
156_T 165_I 1.419 0.95
81_V 140_A 1.413 0.95
96_D 121_R 1.383 0.94
42_G 46_E 1.374 0.94
134_E 162_N 1.354 0.93
53_K 57_K 1.335 0.92
46_E 67_Y 1.332 0.92
7_V 78_V 1.319 0.92
93_R 97_E 1.298 0.91
77_D 139_N 1.286 0.90
36_K 66_S 1.278 0.90
145_Y 150_A 1.269 0.90
139_N 164_K 1.258 0.89
86_R 93_R 1.257 0.89
134_E 161_P 1.237 0.88
76_S 136_Y 1.233 0.88
176_E 193_V 1.232 0.88
100_P 114_G 1.23 0.88
8_V 82_M 1.219 0.87
17_P 109_E 1.212 0.87
72_E 136_Y 1.204 0.86
149_A 172_P 1.195 0.85
37_F 77_D 1.17 0.84
109_E 118_Y 1.156 0.83
109_E 198_L 1.155 0.83
115_G 121_R 1.146 0.82
19_I 84_H 1.129 0.81
45_Q 48_I 1.128 0.81
127_L 155_A 1.126 0.80
117_A 137_S 1.124 0.80
131_D 160_R 1.122 0.80
111_C 151_I 1.111 0.79
86_R 97_E 1.109 0.79
100_P 103_H 1.091 0.77
45_Q 67_Y 1.086 0.77
97_E 107_G 1.075 0.76
69_T 73_V 1.065 0.75
7_V 75_F 1.065 0.75
23_L 35_L 1.061 0.75
110_T 115_G 1.054 0.74
83_A 126_V 1.051 0.74
5_S 34_A 1.048 0.73
96_D 115_G 1.04 0.73
81_V 133_M 1.038 0.72
7_V 70_D 1.035 0.72
86_R 118_Y 1.032 0.72
135_K 162_N 1.028 0.71
153_A 157_R 1.021 0.71
193_V 202_W 1.02 0.71
179_M 193_V 1.019 0.70
40_N 89_K 1.017 0.70
185_L 190_Q 1.012 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u8xX10.98581000.421Contact Map0.571
1up7A80.95281000.425Contact Map0.726
1obbA20.9671000.428Contact Map0.623
1s6yA10.97641000.434Contact Map0.724
3u95A60.95281000.456Contact Map0.619
3fefA40.95751000.476Contact Map0.671
1pzgA40.89621000.643Contact Map0.631
1t2dA10.87261000.657Contact Map0.633
3gviA60.86321000.662Contact Map0.706
3p7mA40.84911000.671Contact Map0.724
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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