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OPENSEQ.org
MENC - o-succinylbenzoate synthase
UniProt: P29208 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11532
Length: 320 (298)
Sequences: 3198
Seq/Len: 10.73
MENC
Paralog alert: 0.56 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: AEEP DGOD GUDD GUDX MENC RHMD RSPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
88_S 243_E 3.441 1.00
5_Q 33_C 3.31 1.00
39_R 94_L 3.29 1.00
175_A 189_L 3.17 1.00
203_A 230_R 3.094 1.00
167_T 170_K 2.954 1.00
35_R 40_E 2.918 1.00
219_P 244_K 2.913 1.00
96_D 100_Q 2.833 1.00
122_A 152_A 2.532 1.00
36_E 94_L 2.474 1.00
176_K 179_N 2.425 1.00
224_V 257_L 2.401 1.00
33_C 40_E 2.396 1.00
118_I 152_A 2.265 1.00
200_R 226_E 2.144 1.00
172_Q 205_E 2.141 1.00
221_F 225_A 2.14 1.00
177_Y 180_P 2.133 1.00
195_T 198_D 2.131 1.00
179_N 207_G 2.091 1.00
200_R 204_R 2.073 1.00
172_Q 202_F 2.044 1.00
175_A 206_T 2.027 1.00
239_T 248_Q 2.027 1.00
174_F 178_V 2.024 1.00
36_E 39_R 2.022 1.00
88_S 92_A 2.014 1.00
108_P 128_K 1.988 1.00
114_P 118_I 1.977 1.00
60_Q 64_L 1.93 1.00
133_K 163_N 1.916 1.00
201_A 204_R 1.88 1.00
179_N 208_I 1.87 1.00
98_L 102_A 1.842 1.00
250_Q 253_H 1.833 1.00
222_A 226_E 1.815 1.00
193_C 202_F 1.783 1.00
10_Q 26_T 1.782 1.00
113_D 116_D 1.767 1.00
93_E 97_T 1.757 1.00
157_H 187_A 1.716 1.00
211_A 233_V 1.705 1.00
143_G 177_Y 1.693 1.00
168_P 202_F 1.672 1.00
34_L 91_L 1.642 1.00
147_N 151_E 1.633 1.00
245_V 277_I 1.632 1.00
234_I 245_V 1.629 1.00
236_P 245_V 1.628 1.00
197_D 226_E 1.625 1.00
7_Y 33_C 1.623 1.00
116_D 119_L 1.614 1.00
18_V 23_R 1.614 1.00
148_L 151_E 1.605 1.00
147_N 180_P 1.602 1.00
5_Q 35_R 1.602 1.00
92_A 243_E 1.597 1.00
45_I 86_G 1.597 1.00
159_R 187_A 1.593 1.00
146_V 181_D 1.588 1.00
147_N 181_D 1.586 1.00
160_L 186_I 1.548 1.00
3_S 35_R 1.533 1.00
244_K 247_E 1.533 1.00
33_C 42_W 1.505 1.00
130_A 156_L 1.497 1.00
31_Y 42_W 1.49 1.00
247_E 253_H 1.481 1.00
144_M 147_N 1.473 1.00
119_L 122_A 1.45 1.00
150_L 154_P 1.444 1.00
239_T 245_V 1.432 1.00
61_S 65_A 1.407 0.99
201_A 205_E 1.402 0.99
141_R 144_M 1.399 0.99
191_E 233_V 1.391 0.99
179_N 206_T 1.389 0.99
224_V 251_A 1.388 0.99
225_A 255_L 1.381 0.99
4_A 34_L 1.375 0.99
112_G 116_D 1.374 0.99
176_K 207_G 1.371 0.99
251_A 254_A 1.37 0.99
148_L 152_A 1.364 0.99
69_N 72_A 1.357 0.99
172_Q 201_A 1.347 0.99
138_E 141_R 1.342 0.99
135_G 142_D 1.336 0.99
143_G 181_D 1.335 0.99
162_A 189_L 1.322 0.99
39_R 97_T 1.322 0.99
192_P 210_I 1.305 0.99
223_F 229_V 1.304 0.99
222_A 225_A 1.294 0.99
16_G 23_R 1.273 0.99
8_R 28_D 1.267 0.99
246_R 250_Q 1.253 0.99
120_K 123_D 1.244 0.98
146_V 178_V 1.244 0.98
197_D 222_A 1.238 0.98
153_I 158_L 1.222 0.98
10_Q 28_D 1.207 0.98
121_L 153_I 1.2 0.98
119_L 123_D 1.188 0.98
193_C 198_D 1.187 0.98
75_C 102_A 1.186 0.98
118_I 153_I 1.181 0.98
150_L 158_L 1.177 0.98
236_P 274_L 1.157 0.97
168_P 201_A 1.145 0.97
132_V 149_L 1.131 0.97
34_L 71_L 1.128 0.97
196_R 228_G 1.11 0.96
134_V 160_L 1.108 0.96
162_A 166_W 1.106 0.96
166_W 174_F 1.102 0.96
191_E 213_D 1.096 0.96
235_K 262_S 1.093 0.96
134_V 166_W 1.093 0.96
129_V 159_R 1.089 0.96
213_D 235_K 1.087 0.96
87_V 91_L 1.086 0.96
143_G 180_P 1.075 0.95
150_L 155_D 1.072 0.95
79_Q 103_N 1.069 0.95
67_V 87_V 1.064 0.95
118_I 122_A 1.064 0.95
166_W 189_L 1.058 0.95
15_A 120_K 1.054 0.95
144_M 148_L 1.054 0.95
140_V 144_M 1.052 0.95
202_F 210_I 1.049 0.94
89_C 273_Q 1.049 0.94
233_V 262_S 1.049 0.94
149_L 153_I 1.045 0.94
186_I 208_I 1.042 0.94
193_C 199_S 1.042 0.94
212_W 223_F 1.041 0.94
268_S 298_Q 1.039 0.94
216_L 223_F 1.038 0.94
35_R 38_E 1.037 0.94
35_R 42_W 1.031 0.94
101_A 276_R 1.03 0.94
41_G 90_A 1.029 0.94
143_G 147_N 1.026 0.94
160_L 189_L 1.017 0.93
200_R 228_G 1.015 0.93
115_D 119_L 1.013 0.93
258_T 285_T 1.011 0.93
32_V 86_G 1.003 0.93
199_S 212_W 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1r6wA10.98121000.129Contact Map0.566
3s5sA20.98441000.198Contact Map0.688
3u9iA20.97811000.211Contact Map0.743
2pgeA10.97191000.216Contact Map0.692
2p8bA10.98441000.225Contact Map0.765
3i4kA80.99061000.226Contact Map0.808
3i6eA80.98751000.226Contact Map0.722
3r0uA20.98441000.228Contact Map0.794
1tkkA80.98751000.23Contact Map0.873
3fcpA80.98751000.23Contact Map0.786
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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