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YBFD - H repeat-associated protein YbfD
UniProt: P28916 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11524
Length: 253 (248)
Sequences: 270
Seq/Len: 1.09

YBFD
Paralog alert: 0.53 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: YBFD YBFL YDCC YHHI YNCI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
195_V 206_F 4.153 1.00
181_A 193_F 2.957 1.00
152_I 177_Q 2.677 1.00
73_T 76_R 2.482 0.99
156_P 180_I 2.068 0.97
106_I 189_G 2.058 0.97
32_L 64_F 2.045 0.97
175_G 180_I 2.028 0.97
18_Q 21_K 1.946 0.95
160_N 183_K 1.912 0.95
149_S 152_I 1.896 0.94
10_I 13_I 1.872 0.94
183_K 187_Q 1.867 0.94
155_I 175_G 1.859 0.94
149_S 153_T 1.821 0.93
14_P 85_K 1.781 0.92
149_S 154_A 1.759 0.91
155_I 180_I 1.741 0.90
168_I 192_L 1.734 0.90
32_L 55_P 1.7 0.89
112_I 127_H 1.698 0.89
36_A 41_A 1.694 0.89
171_T 175_G 1.647 0.87
105_V 170_K 1.628 0.86
140_I 170_K 1.608 0.85
48_E 68_I 1.574 0.83
24_H 76_R 1.569 0.83
155_I 171_T 1.559 0.82
174_M 180_I 1.551 0.82
195_V 200_G 1.49 0.78
131_A 158_L 1.48 0.78
106_I 131_A 1.473 0.77
156_P 175_G 1.468 0.77
24_H 68_I 1.464 0.77
51_G 68_I 1.461 0.76
18_Q 22_V 1.459 0.76
74_I 78_V 1.457 0.76
32_L 51_G 1.449 0.76
29_I 77_V 1.433 0.74
55_P 59_K 1.425 0.74
44_W 50_F 1.411 0.73
44_W 78_V 1.404 0.72
197_G 203_N 1.39 0.71
184_I 189_G 1.373 0.70
31_L 57_F 1.365 0.69
19_A 22_V 1.356 0.68
150_N 174_M 1.316 0.65
194_A 240_V 1.311 0.65
10_I 89_S 1.31 0.65
208_E 244_P 1.298 0.64
153_T 180_I 1.287 0.63
6_L 30_L 1.283 0.62
33_T 74_I 1.281 0.62
203_N 207_E 1.278 0.62
171_T 180_I 1.275 0.61
87_H 91_I 1.269 0.61
29_I 32_L 1.252 0.59
127_H 181_A 1.251 0.59
224_A 237_L 1.251 0.59
90_F 130_S 1.249 0.59
83_P 189_G 1.243 0.59
32_L 74_I 1.24 0.58
133_S 168_I 1.235 0.58
28_D 64_F 1.219 0.56
141_G 149_S 1.215 0.56
149_S 156_P 1.211 0.56
171_T 174_M 1.208 0.55
150_N 153_T 1.199 0.54
33_T 37_V 1.199 0.54
75_A 79_S 1.196 0.54
33_T 78_V 1.185 0.53
104_D 133_S 1.184 0.53
243_V 246_E 1.181 0.53
164_I 169_I 1.165 0.51
142_Q 145_T 1.157 0.50
177_Q 180_I 1.156 0.50
231_G 236_R 1.146 0.49
26_L 77_V 1.146 0.49
127_H 142_Q 1.139 0.49
190_D 202_L 1.135 0.48
48_E 52_E 1.133 0.48
71_H 75_A 1.127 0.48
149_S 174_M 1.125 0.47
192_L 238_H 1.122 0.47
209_K 246_E 1.121 0.47
33_T 200_G 1.117 0.47
150_N 177_Q 1.117 0.47
30_L 245_D 1.112 0.46
59_K 63_D 1.103 0.45
152_I 158_L 1.099 0.45
156_P 171_T 1.099 0.45
48_E 71_H 1.098 0.45
164_I 188_G 1.093 0.44
128_V 176_C 1.079 0.43
126_I 144_K 1.071 0.42
13_I 89_S 1.065 0.42
241_C 246_E 1.06 0.41
24_H 77_V 1.06 0.41
108_I 117_Y 1.057 0.41
174_M 177_Q 1.051 0.41
37_V 114_R 1.048 0.40
46_D 116_S 1.042 0.40
113_H 126_I 1.027 0.38
72_D 86_F 1.026 0.38
189_G 199_Q 1.024 0.38
81_I 228_K 1.021 0.38
152_I 174_M 1.019 0.38
127_H 159_L 1.009 0.37
150_N 180_I 1.008 0.37
106_I 164_I 1.007 0.37
232_R 236_R 1.006 0.36
149_S 158_L 1.006 0.36
39_S 52_E 1.002 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1musA10.849892.50.939Contact Map0.323
3bpyA10.312311.80.97Contact Map0.124
1neeA10.47436.20.974Contact Map0.107
1k78A30.31625.50.974Contact Map0.726
1iufA10.43485.20.975Contact Map0.204
3l2cA10.39925.20.975Contact Map0.135
1pdnC10.27675.10.975Contact Map0.485
2b7eA10.18584.50.975Contact Map0.505
1aisA10.24514.30.976Contact Map0.162
3cw2K40.47434.20.976Contact Map0.143

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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