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OPENSEQ.org
DING - Probable ATP-dependent helicase DinG
UniProt: P27296 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11357
Length: 716 (684)
Sequences: 1507
Seq/Len: 2.20
DING
Paralog alert: 0.48 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DING YOAA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
493_N 496_E 5.174 1.00
227_V 247_L 4.36 1.00
68_G 246_V 3.567 1.00
541_F 589_V 3.518 1.00
34_M 52_I 3.5 1.00
541_F 550_F 3.5 1.00
554_V 589_V 3.219 1.00
536_G 606_S 3.17 1.00
630_L 635_R 3.165 1.00
250_G 457_V 2.761 1.00
120_C 205_C 2.755 1.00
544_G 591_L 2.692 1.00
42_L 244_L 2.467 1.00
635_R 640_V 2.445 1.00
444_L 449_W 2.406 1.00
601_K 660_S 2.384 1.00
595_A 653_Q 2.375 1.00
650_L 683_L 2.242 1.00
631_K 637_P 2.205 1.00
37_D 486_V 2.167 1.00
647_S 683_L 2.163 1.00
26_I 661_H 2.118 1.00
536_G 559_L 2.09 0.99
34_M 458_T 2.073 0.99
529_V 537_M 2.029 0.99
497_Q 658_I 2.016 0.99
547_M 563_V 2.011 0.99
533_K 537_M 2.008 0.99
562_L 586_S 1.98 0.99
657_L 665_G 1.97 0.99
669_I 674_L 1.968 0.99
28_R 31_Q 1.958 0.99
30_P 488_L 1.949 0.99
650_L 669_I 1.922 0.99
501_V 668_V 1.856 0.98
68_G 79_L 1.835 0.98
608_V 657_L 1.829 0.98
82_S 224_H 1.822 0.98
547_M 589_V 1.82 0.98
80_V 245_L 1.813 0.98
97_L 221_V 1.804 0.98
538_L 590_G 1.798 0.98
519_A 553_Y 1.771 0.98
472_Q 485_F 1.735 0.97
61_T 247_L 1.73 0.97
592_Q 649_N 1.726 0.97
29_A 33_Q 1.724 0.97
81_V 92_I 1.722 0.97
252_H 596_E 1.719 0.97
247_L 253_L 1.701 0.97
42_L 456_I 1.66 0.96
544_G 547_M 1.636 0.96
194_C 199_C 1.626 0.96
551_L 563_V 1.624 0.96
610_I 667_V 1.622 0.96
630_L 641_Q 1.619 0.95
97_L 219_V 1.618 0.95
600_L 604_L 1.614 0.95
88_L 91_Q 1.609 0.95
93_Y 221_V 1.605 0.95
525_F 609_H 1.593 0.95
650_L 687_L 1.585 0.95
544_G 548_Q 1.58 0.95
541_F 547_M 1.566 0.94
61_T 278_L 1.56 0.94
51_A 471_L 1.56 0.94
90_D 94_S 1.555 0.94
669_I 687_L 1.554 0.94
55_P 494_H 1.536 0.93
627_G 631_K 1.521 0.93
654_V 667_V 1.514 0.93
537_M 607_Q 1.5 0.92
449_W 457_V 1.495 0.92
63_S 67_P 1.487 0.92
463_R 487_A 1.487 0.92
569_R 594_F 1.487 0.92
499_K 666_E 1.481 0.92
502_I 675_L 1.465 0.91
114_G 223_N 1.452 0.91
607_Q 668_V 1.451 0.91
471_L 475_S 1.447 0.91
228_M 253_L 1.428 0.90
114_G 117_R 1.421 0.89
51_A 475_S 1.414 0.89
121_P 206_P 1.411 0.89
245_L 452_I 1.411 0.89
28_R 54_A 1.4 0.88
491_P 602_G 1.4 0.88
32_R 36_A 1.399 0.88
603_D 606_S 1.398 0.88
581_A 604_L 1.393 0.88
120_C 199_C 1.385 0.88
545_R 549_R 1.384 0.88
453_P 685_D 1.384 0.88
53_E 487_A 1.38 0.88
225_A 436_V 1.376 0.87
460_A 492_F 1.371 0.87
224_H 540_L 1.363 0.87
550_F 589_V 1.362 0.87
571_R 574_E 1.36 0.86
254_P 474_M 1.357 0.86
64_Y 224_H 1.357 0.86
92_I 96_D 1.344 0.86
528_Q 668_V 1.344 0.86
89_Q 223_N 1.342 0.86
251_H 459_S 1.338 0.85
77_K 241_K 1.336 0.85
80_V 240_P 1.327 0.85
122_R 195_L 1.317 0.84
572_L 588_L 1.311 0.84
627_G 642_S 1.31 0.84
500_I 669_I 1.307 0.83
55_P 625_T 1.305 0.83
628_E 631_K 1.301 0.83
86_V 605_L 1.298 0.83
88_L 615_F 1.293 0.82
561_L 590_G 1.292 0.82
521_M 525_F 1.29 0.82
112_A 220_V 1.283 0.82
538_L 601_K 1.281 0.82
677_K 680_G 1.279 0.82
83_T 223_N 1.265 0.81
64_Y 88_L 1.254 0.80
569_R 573_V 1.252 0.80
97_L 109_F 1.251 0.80
606_S 664_W 1.248 0.79
460_A 490_S 1.248 0.79
538_L 653_Q 1.247 0.79
85_N 614_A 1.244 0.79
189_T 205_C 1.244 0.79
64_Y 540_L 1.244 0.79
42_L 246_V 1.239 0.79
225_A 260_A 1.231 0.78
636_Y 639_E 1.226 0.78
494_H 542_A 1.215 0.77
222_A 613_I 1.215 0.77
560_M 584_E 1.21 0.76
64_Y 81_V 1.208 0.76
591_L 595_A 1.208 0.76
119_V 683_L 1.207 0.76
64_Y 458_T 1.205 0.76
255_D 645_S 1.198 0.75
522_A 550_F 1.196 0.75
63_S 92_I 1.196 0.75
206_P 595_A 1.195 0.75
88_L 223_N 1.194 0.75
278_L 281_K 1.193 0.75
115_R 205_C 1.192 0.75
100_L 622_V 1.19 0.75
247_L 457_V 1.187 0.74
205_C 251_H 1.186 0.74
498_G 657_L 1.185 0.74
169_D 174_H 1.183 0.74
596_E 644_P 1.177 0.73
468_F 688_P 1.176 0.73
86_V 117_R 1.174 0.73
65_L 608_V 1.173 0.73
542_A 612_K 1.171 0.73
254_P 471_L 1.17 0.73
28_R 605_L 1.168 0.73
654_V 690_F 1.167 0.73
48_R 484_R 1.166 0.72
35_I 100_L 1.165 0.72
84_A 252_H 1.165 0.72
445_E 450_R 1.164 0.72
279_F 282_L 1.164 0.72
449_W 455_I 1.161 0.72
629_W 633_L 1.16 0.72
113_F 223_N 1.158 0.72
492_F 638_F 1.156 0.72
652_Q 656_R 1.155 0.71
26_I 254_P 1.154 0.71
655_G 659_R 1.153 0.71
605_L 657_L 1.153 0.71
51_A 472_Q 1.153 0.71
312_Y 316_A 1.152 0.71
57_G 60_K 1.151 0.71
88_L 113_F 1.146 0.71
615_F 638_F 1.145 0.71
96_D 437_G 1.144 0.70
546_A 611_H 1.143 0.70
83_T 89_Q 1.141 0.70
623_V 642_S 1.137 0.70
656_R 659_R 1.136 0.70
610_I 654_V 1.136 0.70
97_L 101_K 1.13 0.69
62_L 648_F 1.129 0.69
189_T 193_S 1.129 0.69
55_P 488_L 1.129 0.69
49_H 454_H 1.128 0.69
273_R 431_L 1.128 0.69
595_A 651_I 1.127 0.69
79_L 220_V 1.126 0.69
95_K 184_W 1.125 0.69
18_L 22_I 1.125 0.69
609_H 670_Y 1.125 0.69
88_L 540_L 1.124 0.68
202_Y 207_F 1.121 0.68
674_L 684_L 1.116 0.68
561_L 575_L 1.116 0.68
227_V 245_L 1.116 0.68
474_M 635_R 1.114 0.67
553_Y 556_D 1.112 0.67
240_P 245_L 1.109 0.67
41_T 50_L 1.108 0.67
41_T 454_H 1.107 0.67
120_C 194_C 1.106 0.67
659_R 663_C 1.106 0.67
41_T 47_G 1.105 0.67
54_A 605_L 1.103 0.66
254_P 470_R 1.101 0.66
112_A 214_I 1.101 0.66
211_R 509_P 1.099 0.66
38_V 50_L 1.097 0.66
605_L 665_G 1.094 0.65
206_P 612_K 1.093 0.65
638_F 680_G 1.093 0.65
372_E 380_V 1.093 0.65
594_F 644_P 1.091 0.65
538_L 600_L 1.087 0.65
116_G 598_L 1.085 0.64
195_L 200_Y 1.084 0.64
84_A 256_V 1.083 0.64
648_F 651_I 1.081 0.64
537_M 606_S 1.08 0.64
34_M 38_V 1.079 0.64
495_C 689_V 1.079 0.64
52_I 488_L 1.078 0.64
90_D 546_A 1.078 0.64
569_R 605_L 1.078 0.64
222_A 227_V 1.077 0.64
463_R 468_F 1.077 0.64
37_D 40_K 1.077 0.64
114_G 226_L 1.077 0.64
452_I 455_I 1.077 0.64
144_E 148_N 1.076 0.64
509_P 672_K 1.075 0.63
69_I 219_V 1.075 0.63
61_T 92_I 1.074 0.63
88_L 224_H 1.073 0.63
652_Q 655_G 1.067 0.63
219_V 246_V 1.064 0.62
609_H 686_A 1.064 0.62
22_I 51_A 1.06 0.62
540_L 595_A 1.057 0.61
549_R 552_D 1.057 0.61
69_I 97_L 1.055 0.61
554_V 561_L 1.054 0.61
498_G 654_V 1.053 0.61
105_P 669_I 1.052 0.61
28_R 657_L 1.052 0.61
70_A 536_G 1.052 0.61
38_V 41_T 1.052 0.61
535_L 576_H 1.052 0.61
542_A 595_A 1.05 0.61
544_G 683_L 1.048 0.61
563_V 589_V 1.045 0.60
54_A 602_G 1.043 0.60
527_K 531_S 1.042 0.60
254_P 449_W 1.039 0.60
100_L 454_H 1.038 0.59
123_N 187_L 1.037 0.59
117_R 206_P 1.032 0.59
53_E 665_G 1.03 0.59
84_A 683_L 1.03 0.59
114_G 492_F 1.03 0.59
485_F 668_V 1.027 0.58
37_D 50_L 1.026 0.58
650_L 674_L 1.026 0.58
170_G 173_D 1.022 0.58
191_K 661_H 1.021 0.58
199_C 205_C 1.021 0.58
58_V 497_Q 1.021 0.58
538_L 598_L 1.021 0.58
644_P 682_R 1.018 0.57
63_S 95_K 1.017 0.57
615_F 618_I 1.016 0.57
498_G 690_F 1.013 0.57
108_K 456_I 1.012 0.57
56_T 438_I 1.011 0.56
188_S 193_S 1.011 0.56
54_A 223_N 1.011 0.56
559_L 587_V 1.011 0.56
539_V 587_V 1.01 0.56
646_A 673_R 1.01 0.56
457_V 471_L 1.004 0.56
241_K 590_G 1.004 0.56
607_Q 611_H 1.003 0.56
215_Q 448_L 1.003 0.56
444_L 468_F 1.001 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a15A10.83661000.407Contact Map0.487
3crvA10.751000.463Contact Map0.401
2vl7A10.7361000.489Contact Map0.524
1gkuB10.56421000.813Contact Map0.395
3juxA10.7571000.82Contact Map0.478
3oiyA20.553199.90.856Contact Map0.468
3fhoA20.519699.90.858Contact Map0.377
2ykgA10.706799.90.858Contact Map0.392
4bgdA10.56799.90.858Contact Map0.481
4gl2A20.708199.90.858Contact Map0.359
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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