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OPENSEQ.org
FEPE - Ferric enterobactin transport protein FepE
UniProt: P26266 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10297
Length: 377 (334)
Sequences: 2102
Seq/Len: 6.29
FEPE
Paralog alert: 0.69 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: FEPE WZZB WZZE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
178_A 184_A 4.152 1.00
189_S 327_P 4.04 1.00
54_G 345_S 3.832 1.00
66_T 334_D 3.475 1.00
58_S 341_I 3.211 1.00
37_W 40_K 3.061 1.00
353_A 357_V 3.017 1.00
57_I 61_L 3.008 1.00
178_A 183_E 2.803 1.00
185_Q 189_S 2.661 1.00
66_T 177_T 2.653 1.00
69_A 192_I 2.536 1.00
264_K 279_E 2.413 1.00
185_Q 329_L 2.348 1.00
182_E 186_T 2.32 1.00
28_D 31_N 2.277 1.00
337_G 340_I 2.232 1.00
219_K 223_A 2.191 1.00
146_V 150_E 2.182 1.00
174_L 188_L 2.171 1.00
58_S 342_V 2.153 1.00
109_K 141_L 2.105 1.00
177_T 335_G 2.088 1.00
227_I 231_N 2.06 1.00
55_L 59_F 2.009 1.00
176_F 187_V 1.993 1.00
67_S 184_A 1.964 1.00
39_A 360_R 1.956 1.00
51_A 346_A 1.931 1.00
151_K 176_F 1.863 1.00
47_V 350_G 1.825 1.00
58_S 345_S 1.812 1.00
66_T 175_S 1.776 1.00
105_N 109_K 1.77 1.00
278_I 282_L 1.752 1.00
50_F 54_G 1.733 1.00
225_D 300_N 1.728 1.00
55_L 342_V 1.719 1.00
282_L 286_K 1.712 1.00
196_S 200_V 1.67 1.00
236_N 239_R 1.659 1.00
296_G 299_R 1.648 1.00
345_S 349_G 1.577 0.99
171_S 324_Q 1.548 0.99
279_E 283_E 1.525 0.99
214_K 217_F 1.508 0.99
104_F 148_L 1.503 0.99
222_L 226_R 1.5 0.99
301_R 305_V 1.498 0.99
224_Q 228_K 1.495 0.99
349_G 353_A 1.493 0.99
243_S 246_I 1.47 0.99
233_L 299_R 1.468 0.99
221_K 300_N 1.451 0.99
62_P 179_P 1.45 0.99
43_V 357_V 1.423 0.99
152_M 176_F 1.421 0.99
54_G 341_I 1.41 0.98
36_L 354_C 1.408 0.98
176_F 188_L 1.406 0.98
57_I 341_I 1.39 0.98
43_V 47_V 1.365 0.98
56_L 60_I 1.345 0.98
348_I 355_G 1.332 0.98
35_V 361_Y 1.328 0.98
190_G 193_D 1.322 0.97
192_I 323_Y 1.319 0.97
193_D 196_S 1.306 0.97
338_K 341_I 1.302 0.97
110_K 190_G 1.294 0.97
58_S 61_L 1.284 0.97
148_L 176_F 1.282 0.97
45_A 52_C 1.263 0.96
64_K 335_G 1.254 0.96
193_D 326_S 1.251 0.96
262_A 266_D 1.247 0.96
50_F 349_G 1.246 0.96
51_A 342_V 1.243 0.96
36_L 43_V 1.235 0.96
335_G 338_K 1.221 0.95
276_D 279_E 1.221 0.95
239_R 243_S 1.216 0.95
239_R 242_Y 1.215 0.95
108_I 113_S 1.21 0.95
46_V 353_A 1.208 0.95
283_E 287_A 1.207 0.95
104_F 149_S 1.2 0.95
347_L 351_M 1.2 0.95
103_A 191_Y 1.2 0.95
69_A 174_L 1.197 0.95
264_K 269_F 1.186 0.94
220_E 224_Q 1.184 0.94
177_T 334_D 1.181 0.94
39_A 357_V 1.174 0.94
108_I 145_I 1.172 0.94
174_L 192_I 1.17 0.94
352_V 355_G 1.169 0.94
67_S 329_L 1.165 0.94
364_A 368_Q 1.159 0.93
278_I 281_K 1.154 0.93
46_V 356_G 1.148 0.93
210_K 300_N 1.14 0.93
54_G 58_S 1.139 0.93
70_V 171_S 1.137 0.93
97_K 194_Y 1.136 0.93
225_D 228_K 1.135 0.92
64_K 177_T 1.133 0.92
43_V 354_C 1.131 0.92
235_A 239_R 1.13 0.92
50_F 352_V 1.128 0.92
40_K 44_M 1.117 0.92
104_F 187_V 1.114 0.92
128_M 132_K 1.11 0.91
163_K 321_F 1.108 0.91
312_H 315_D 1.106 0.91
106_L 109_K 1.105 0.91
340_I 344_L 1.104 0.91
277_G 281_K 1.104 0.91
49_A 53_A 1.103 0.91
94_L 97_K 1.103 0.91
288_V 291_V 1.101 0.91
202_E 320_P 1.096 0.91
100_R 194_Y 1.095 0.91
147_A 151_K 1.095 0.91
101_T 325_L 1.094 0.91
346_A 350_G 1.091 0.90
155_V 173_T 1.084 0.90
107_F 111_F 1.068 0.89
68_A 173_T 1.062 0.89
216_Q 219_K 1.06 0.89
198_L 320_P 1.058 0.89
356_G 360_R 1.057 0.88
242_Y 246_I 1.056 0.88
58_S 338_K 1.056 0.88
183_E 186_T 1.053 0.88
194_Y 321_F 1.049 0.88
279_E 282_L 1.047 0.88
67_S 185_Q 1.045 0.88
35_V 358_L 1.042 0.88
156_D 170_T 1.041 0.87
53_A 57_I 1.039 0.87
51_A 350_G 1.037 0.87
59_F 342_V 1.035 0.87
117_L 120_Y 1.028 0.87
341_I 345_S 1.027 0.86
123_S 126_Y 1.024 0.86
107_F 187_V 1.021 0.86
46_V 50_F 1.02 0.86
354_C 358_L 1.019 0.86
148_L 187_V 1.019 0.86
344_L 362_A 1.017 0.86
333_K 338_K 1.014 0.86
241_N 248_N 1.013 0.85
36_L 357_V 1.012 0.85
108_I 111_F 1.009 0.85
188_L 192_I 1.005 0.85
269_F 278_I 1.003 0.85
42_T 46_V 1.001 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3b8mA30.740199.90.641Contact Map0.633
3b8oA80.673799.90.695Contact Map0.702
4e29A20.647299.80.728Contact Map0.574
2kluA10.114142.70.95Contact Map0.188
2kncB10.124720.30.957Contact Map0.449
2m20A20.106113.90.96Contact Map0.364
2k1kA20.100813.70.961Contact Map0.3
3tnuB10.315612.20.961Contact Map0.543
2wwbB10.1751100.963Contact Map0.388
3tnuA10.28658.70.964Contact Map0.567
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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