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OPENSEQ.org
PPIB - Peptidyl-prolyl cis-trans isomerase B
UniProt: P23869 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10758
Length: 164 (156)
Sequences: 5531
Seq/Len: 35.46
PPIB
Paralog alert: 0.66 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: PPIA PPIB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
12_V 128_D 3.114 1.00
80_R 134_D 3.067 1.00
81_G 130_M 2.915 1.00
37_N 159_S 2.807 1.00
5_H 10_D 2.729 1.00
102_V 137_K 2.716 1.00
78_N 84_A 2.327 1.00
84_A 99_F 2.211 1.00
39_T 52_G 2.196 1.00
22_E 69_K 2.122 1.00
11_I 133_V 2.118 1.00
25_K 29_D 2.11 1.00
14_K 125_E 2.071 1.00
29_D 33_E 2.06 1.00
79_T 125_E 2.004 1.00
3_T 10_D 1.857 1.00
11_I 126_V 1.832 1.00
68_I 94_A 1.805 1.00
4_F 11_I 1.775 1.00
4_F 13_I 1.765 1.00
40_I 154_D 1.744 1.00
4_F 160_V 1.704 1.00
82_T 101_N 1.669 1.00
82_T 125_E 1.661 1.00
139_V 155_V 1.652 1.00
3_T 163_S 1.622 1.00
13_I 83_L 1.617 1.00
14_K 127_V 1.614 1.00
8_H 135_K 1.563 1.00
44_V 136_I 1.492 1.00
5_H 161_T 1.481 1.00
50_I 102_V 1.474 1.00
14_K 17_D 1.466 1.00
46_N 137_K 1.465 1.00
17_D 24_V 1.458 1.00
140_A 152_K 1.453 1.00
31_C 160_V 1.414 1.00
15_T 24_V 1.412 1.00
69_K 92_H 1.363 0.99
45_I 49_M 1.357 0.99
16_F 125_E 1.341 0.99
35_F 61_Q 1.34 0.99
79_T 82_T 1.325 0.99
50_I 136_I 1.325 0.99
19_K 76_L 1.321 0.99
46_N 141_T 1.311 0.99
5_H 158_E 1.304 0.99
81_G 134_D 1.304 0.99
77_K 109_N 1.286 0.99
28_L 32_R 1.286 0.99
46_N 138_G 1.285 0.99
101_N 105_N 1.279 0.99
39_T 54_G 1.263 0.99
32_R 162_V 1.26 0.99
157_I 160_V 1.26 0.99
29_D 65_K 1.246 0.98
20_A 24_V 1.245 0.98
3_T 161_T 1.22 0.98
3_T 12_V 1.214 0.98
5_H 159_S 1.212 0.98
33_E 65_K 1.208 0.98
19_K 75_G 1.2 0.98
130_M 133_V 1.163 0.97
2_V 28_L 1.158 0.97
136_I 155_V 1.15 0.97
126_V 133_V 1.146 0.97
23_T 85_M 1.135 0.97
47_G 103_V 1.135 0.97
140_A 149_D 1.109 0.96
16_F 19_K 1.089 0.96
142_G 152_K 1.089 0.96
55_F 61_Q 1.078 0.95
134_D 137_K 1.075 0.95
25_K 28_L 1.064 0.95
78_N 109_N 1.059 0.95
100_I 133_V 1.056 0.95
72_A 110_F 1.049 0.94
141_T 149_D 1.046 0.94
64_T 95_T 1.042 0.94
82_T 122_V 1.042 0.94
7_N 158_E 1.027 0.94
22_E 25_K 1.023 0.93
87_R 94_A 1.023 0.93
29_D 32_R 1.02 0.93
84_A 122_V 1.018 0.93
12_V 127_V 1.017 0.93
130_M 134_D 1.017 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1lopA111000.046Contact Map0.841
2k7nA10.92071000.051Contact Map0.628
3s6mA10.99391000.053Contact Map0.804
2x7kA10.92071000.055Contact Map0.809
1zkcA20.92681000.057Contact Map0.801
2fu0A10.92071000.058Contact Map0.867
2b71A10.92071000.058Contact Map0.819
2poeA10.92681000.058Contact Map0.78
3bo7A40.92071000.062Contact Map0.834
2ok3A10.92071000.064Contact Map0.75
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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